Oxidative damage and delayed replication allow viable <i>Mycobacterium tuberculosis</i> to go undetected
Kohta Saito, Saurabh Mishra, Thulasi Warrier, Nico Cicchetti, Jianjie Mi, Elaina Weber, Xiuju Jiang, Julia Roberts, et al. (13 authors)
Science Translational Medicine · 2021-11
Abstract
and its derivative, BCG, fail to enter the DD state under similar conditions. These findings have implications for tuberculosis latency, detection, relapse, treatment monitoring, and development of regimens that overcome phenotypic antimicrobial resistance.
MeSH terms
- Mycobacterium tuberculosis
- Tuberculosis
- Microbiology
- Biology
- Multidrug tolerance
- Phenotype
- Antibiotic resistance
- Viable but nonculturable
- Virology
- Bacteria