Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment
Antimycobacterial Susceptibility Testing Group, Sophia B. Georghiou, Timothy C. Rodwell, Alexei Korobitsyn, Said Abbadi, Kanchan Ajbani, Jan‐Willem C. Alffenaar, David Alland, et al. (100 authors)
European Respiratory Journal · 2022-04
Abstract
Inappropriately high breakpoints have resulted in systematic false-susceptible AST results to anti-TB drugs. MIC, PK/PD and clinical outcome data should be combined when setting breakpoints to minimise the emergence and spread of antimicrobial resistance.
MeSH terms
- Breakpoint
- Tuberculosis
- Mycobacterium tuberculosis
- Medicine
- Outcome (game theory)
- Antimicrobial
- Intensive care medicine