Multivariate analysis of the effectiveness of bedaquiline-containing chemotherapy regimens in previously treated XDR TB patients

<b>Method:</b> Due to the widespread increase of XDR TB and the lack of choice of effective drugs, chemotherapy of these patients is a serious problem. The efficacy of treatment of XDR TB patients ranges from 29 to 33%. <b>Purpose:</b> Evaluation of therapeutic effectiveness of bedaquiline combined with second-line and other antibiotics in previously treated XDR-TB patients. <b>Methods:</b> 40 XDR-TB, CV + patients with massive bacterial excretion (aged from 22 to 74 yrs) previously ineffectively treated with 2nd-line drugs were observed. Young men prevailed, weighed down by alcohol, drug and tobacco addiction, HIV infection. Most patients had a low adherence to treatment. The course of Bq treatment was carried out in combination with anti-TB antibiotics according to the drug sensitivity test. Evaluation of the treatment effectiveness was performed using multivariate logistic regression analysis. <b>Results:</b> Bacteriological conversion and CV closure were achieved in 45% of cases. 12.5% of cases remained smear positive and 17.5 % died due to TB. Bq treatment did not require cessation of the drug intake. Testing of patients of different age revealed that duration of Bq treatment is a significant predictor of TB outcome in young people (p = 0.03); the presence of moxifloxacin or linezolid were also significant (p = 0.02 or 0.04 respectively). <b>Conclusion:</b> High effectiveness and good tolerance of Bq indicates to the necessity of the drug in the treatment of previously treated XDR TB patients. The high effectiveness of the bedaquiline-containing regimen depends on the presence of moxifloxacin and linezolid in the regimen.