Illuminating Tuberculosis Meningitis with Metagenomics and FLASH Enrichment (S45.005)
Prashanth Ramachandran, Fiona V Cresswell, Charles Langelier, Saharai Caldera, Amy Lyden, Aaron McGeever, Josh Batson, Rene Sit, et al. (15 authors)
Neurology · 2019-04
Abstract
To enhance detection of Mycobacterium tuberculosis meningitis (TBM) and anti-microbial resistance (AMR) mutations in HIV-infected Ugandan adults with meningitis, using metagenomic next generation sequencing (mNGS) of CSF coupled with CRISPR-Cas9 enrichment technology.
MeSH terms
- Metagenomics
- Tuberculosis
- Virology
- Meningitis
- Microbiology
- Medicine
- Biology