Comparison of the efficacy of metagenomic next-generation sequencing and Xpert MTB/RIF in the diagnosis of tuberculous meningitis
Yu G, Wang X, Zhu P, Shen Y, Zhao W, Zhou L
Journal of microbiological methods · 2020-12
Abstract
Metagenomic next-generation sequencing (mNGS) is an emerging sequence-based method that detects genomic information of pathogenic microorganisms from a wide range of clinical specimens. The mNGS has moderate sensitivity and very high specificity for tuberculous meningitis, and the validity of mNGS was higher than that of Xpert MTB/RIF.
MeSH terms
- Humans
- Mycobacterium tuberculosis
- Tuberculosis, Meningeal
- Molecular Diagnostic Techniques
- Bacteriological Techniques
- Sensitivity and Specificity
- Metagenome
- Metagenomics
- High-Throughput Nucleotide Sequencing