Showing 1–25 of 200 documents
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Salman Khan, Nadeem ur Rehman, Mohammad Zubair, Nisar Khan
Abstract Background: Multidrug-resistant tuberculosis (MDRTB) is a growing global health concern that is a chronic danger to world health due to tuberculosis (TB). Objective: The aim of this study was to examine the frequency of both pre extensively drug-resistant tuberculosis (P…
Dipali Maganbhai Gavali, Binita Aring, Hiral Gadhavi, Akhlakahemad Nathamehta, Abhishek B Dave, et al.
… high prevalence in India, accounting for one-fourth of the Tuberculosis (TB) cases in the world. In our study, we aimed to find the prevalence of Pre XDR-TB and XDR-TB amongst newly diagnosed cases of pulmonary MDR-TB who had never been previously treated with second-line drugs.…
Oudghiri A, Karimi H, Chetioui F, Zakham F, Bourkadi JE, et al.
Background The emergence of extensively drug-resistant tuberculosis (XDR-TB) has raised public health concern for global TB control. Although multi drug-resistant tuberculosis (MDR- TB) prevalence and associated genetic mutations in Morocco are well documented, scarce information…
Rim Abbas, Ali Salami, Ghassan Ghssein
Tuberculosis (TB) is an infectious disease caused by bacteria that primarily target the lungs. The transmission of this disease occurs through the air in the form of droplet nuclei. Unfortunately, there has been an emergence of resistance to strains of such infections, such as mu…
Utpat KV, Rajpurohit R, Desai U
Background Drug-resistant tuberculosis (DR-TB) is the most exigent and calamitous challenge encountered in treatment of TB. Extra pulmonary (EP) DR-TB poses a complex diagnostic and therapeutic challenge owing to myriad of presentations and paucibacillary nature. Data available o…
Eskild Petersen, Martin Rao, Giuseppe Ippolito, Gina Gualano, Jeremiah Chakaya, et al.
Tuberculosis today remains the world's number one cause of death from an infectious disease (WHO, 2018aWHO World Health Organization. Global tuberculosis report.2018Google Scholar). According to data from the World Health Organization Global Tuberculosis Report (WHO, 2018aWHO Wor…
Zifodya JS, Kreniske JS, Schiller I, Kohli M, Dendukuri N, et al.
…on (WHO)-recommended rapid tests that simultaneously detect tuberculosis and rifampicin resistance in people with signs and symptoms of tuberculosis. This review builds on our recent extensive Cochrane Review of Xpert MTB/RIF accuracy. Objectives To compare the diagnostic accurac…
Bashir Ullah, Rukhsana Saboor, Muhammad Zahid Iqbal, Atiq Ahmad Bhatti, Abad Ur Rehman, et al.
…o determine the frequency of pre-extensively drug resistant tuberculosis, extensively drug resistant tuberculosis in patients with multi-drug resistant tuberculosis. Study design: Retrospective/observational Place and duration of study: Department of Medicine, Bolan Medical Colle…
Ayushi Sharma, Gyanendra Singh, Rahul Shrivastava
Tuberculosis is a global emergency. Despite two decades of intense research to understand and cure the disease, biological uncertainties prevail and hamper the therapeutic progress. Increasing incidences of multidrug-resistant (MDR) and extensively drug resistant (XDR) Mycobacter…
О.С. Шевченко, L.D. Todoriko, R.S. Shevchenko, S.L. Matvyeyeva, І.А. Овчаренко, et al.
…s well as the treatment regimens in patients with pulmonary tuberculosis. Materials and methods. This study included 100 patients with pulmonary tuberculosis, divided into two groups: Group 1 (n = 52) with drug-susceptible tuberculosis and Group 2 (n = 48) with drug-resistant tub…
Bisson GP, Bastos M, Campbell JR, Bang D, Brust JC, et al.
…ociated with increased mortality during multidrug-resistant tuberculosis treatment, but the extent to which the use of antiretroviral therapy (ART) and anti-tuberculosis medications modify this risk are unclear. Our objective was to evaluate how use of these treatments altered mo…
Yoon Y, Seo H, Kim S, Lee Y, Rahim MA, et al.
Tuberculosis is a highly contagious disease caused by Mycobacterium tuberculosis . It affects about 10 million people each year and is still one of the leading causes of death worldwide. About 2 to 3 billion people (equivalent to 1 in 3 people in the world) are infected with late…
Seo H, Yoon Y, Kim S, Ghorbanian F, Tajdozian H, et al.
Background Tuberculosis is a highly contagious disease caused by Mycobacterium tuberculosis, and the increase in antibiotic resistance threatens humankind. Therefore, there is an urgent need to develop new anti-tuberculosis drugs that can overcome the limitations of existing drug…
KevisetuoAnthony Dzeyie, Saurav Basu, Tanzin Dikid
Introduction: A tuberculosis patient infects several healthy people prior to the diagnosis and initiation of treatment. Indiscriminate spitting in the community has been identified as a challenge to the prevention of tuberculosis; however, knowledge is still limited in terms of a…
Sadhana Awasthi, Neha Verma, Ram Gopal Nautiyal, Hariom Kumar Solanki
Background: Drug Resistant Tuberculosis (DR-TB) has frequently been encountered in India, and its presence has been known virtually from the time anti-TB drugs were introduced for the treatment of Tuberculosis. Multi Drug Resistant Tuberculosis (MDR-TB) is a man-made phenomenon a…
Wu X, Yang J, Tan G, Liu H, Liu Y, et al.
…tigate the drug resistance characteristics of Mycobacterium tuberculosis (MTB) isolates from patients with tuberculosis to 12 antituberculous drugs in China. Methods: All clinical isolates of MTB were isolated from patients with tuberculosis in Shanghai Pulmonary Hospital (SPH) d…
Dr.Talha Bin Liaquat Dr.Khursheed Alam
…trong><em>Background- </em></strong><em>Before diagnosis of tuberculosis in a patients and initiation of treatment, the infected person can infect some healthy people. In order to prevent the tuberculosis </em><em>undiscerning spitting is </em><em>like a challenge, as there is ve…
Guerrero-Bustamante CA, Dedrick RM, Garlena RA, Russell DA, Hatfull GF
The global health burden of human tuberculosis (TB) and the widespread antibiotic resistance of its causative agent Mycobacterium tuberculosis warrant new strategies for TB control. The successful use of a bacteriophage cocktail to treat a Mycobacterium abscessus infection sugges…
Aijaz Nabi Puttoo, Sandeep Tripathi, Naveed Nazir Shah, Ruqeya Nazir, Haamid Bashir, et al.
Drug-resistant tuberculosis (DR-TB) strains are a significant threat to global TB control. Due to a lack of resources and inadequate healthcare infrastructure, it is difficult to identify and monitor drug resistance situations in low and middle-income nations. The study aimed to …
Sondos A. A. Ibnouf, Fatma Esenkaya Taşbent
Background/Aim: Tuberculosis remains a major global health problem with a high morbidity and mortality rate, approximately a quarter of the population is infected with tuberculosis. Drug susceptibility testing is an essential tool for identifying and managing drug-resistant tuber…
Intini E, Kishore G, Udwadia ZF, Richeldi L
Tuberculosis is one of the top ten causes of death and the leading cause from a single infectious agent. Drug-resistant Tuberculosis continues to be a public health crisis. Urgent action is required to improve the coverage and quality of diagnosis, treatment and care for people w…
А. Yu. Savchenko, В. Г. Кукес, М. S. Burenkov, G. V. Rаmenskаya
… The increase in the number of cases of multidrug-resistant tuberculosis (MDR-TB) determines the relevance of the development of new anti-TB drugs (ATDs). Determining the pharmacokinetics of a drug in the context of MDR-TB therapy is an integral part of the study of the original …
Bitrus Joshua Barde, Joseph Okopi, Isiyaku Ahmadu
Tuberculosis (TB) has afflicted humans for millennia and continues to pose a significant threat to public health worldwide. The World Health Organization classified TB as one of the top 10 causes of death globally, with approximately 10 million new cases and 1.4 million TB associ…
Jianguo Shi, Zhengqin Shi, Hao Li, Min Hu, Junbo Nan
…n in cancer patients clearly elevates the risk of acquiring tuberculosis (TB) infection, and traditional diagnostic methods are characterized by low sensitivity (Sen) and long turnaround times. Although the interferon-gamma release assay (IGRA) is widely used, its ability to dist…
Л. В. Домотенко, T. P. Morozova, Mykyta Khramov, А. П. Шепелин
…te the commercial XDR test for susceptibility testing of M. tuberculosis to second line anti-tuberculosis drugs in clinical trials and as part of annual professional testing cycles coordinated by the World Health Organization (WHO). Subjects and Methods. Cultures of M. tuberculos…