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Gómez LM, Paniagua-Saldarriaga LA, Richert Q, Keynan Y, Montes F, et al.
…e risk factors associated with unsuccessful TB treatment in HIV-seropositive and homeless persons, compared with non-HIV-infected and non-homeless persons with TB. We conducted a retrospective cohort study using observational, routinely collected health data from all drug-suscept…
Chabala, Chishala
Children with HIV are highly susceptible to tuberculosis (TB) and often require concurrent antiretroviral treatment (ART) and antituberculosis therapy. However, rifamycins, the key drugs for TB treatment, significantly interact with many ART classes, necessitating adjustments to …
Perlman D, El-Sadr W
…months) for the treatment of pulmonary tuberculosis (TB) in HIV-infected patients. To compare toxicity, survival, and development of resistance in these two regimens. ORIGINAL: To compare the efficacy and safety of induction and continuation therapies for the treatment of pulmon…
Saadick Mugerwa Ssentongo, Kenneth Kwenya, Bonniface Oryokot, Ronald Opito, Susan Alwedo, et al.
…with 500,000 people dying of Tb in 2021. People living with HIV have an 18 times higher risk of having TB, which is associated with poor treatment outcomes. This study aimed to determine the treatment success rate and associated factors among Pulmonary Clinically Diagnosed and Ba…
Naidoo A, Dooley KE, Naidoo K, Padayatchi N, Yende-Zuma N, et al.
Introduction Cotreatment of HIV and tuberculosis (TB) reduces morbidity and mortality in coinfected patients. Availability of antiretroviral treatment (ART) drug options, including within drug classes, is important, particularly in high HIV/TB burden low and middle-income countri…
Lauren A. Saag, Peter F. Rebeiro, Marcelo Cordeiro‐Santos, Afrânio Lineu Kritski, Bruno B. Andrade, et al.
…redictor of poor tuberculosis (TB) treatment outcomes among HIV-negative populations, but the relationship has not been well studied in the context of HIV. We examined the association between HIV and weight change during the first two months of anti-tuberculosis treatment, and al…
Saag L, Rebeiro P, Cordeiro-Santos M, Kritski A, Andrade B, et al.
…redictor of poor tuberculosis (TB) treatment outcomes among HIV-negative populations, but the relationship has not been well studied in the context of HIV. We examined the association between HIV and weight change during the first two months of anti-tuberculosis treatment, and al…
Anushka Naidoo, PhD, Kelly Dooley, MD, Kogieleum Naidoo, PhD
…Tenofovir alafenamide 25mg (Biktarvy®) dosed twice daily in HIV-1 infected, ART-naïve patients with TB co-infection receiving a rifampicin-based tuberculosis (TB) treatment regimen. This study will assess the activity of Bictegravir and dolutegravir-containing ART regimens in pat…
Cielo Ríos, Marcela Vásquez Rojas, Martha Lucía Serrano, Alexandra Porras, Ricardo Luque, et al.
…stigated the delays in the diagnosis of tuberculosis and/or HIV, their treatment initiation, and factors associated with each delay. All drug-susceptible tuberculosis cases diagnosed in 2014 and 2015 in Colombia, with a confirmed diagnosis of HIV were included. A total of 1909 pa…
Eric Nuermberger, MD
…(TBD) during 72 weeks of follow-up among people living with HIV (PLHIV) and high-risk Close Contacts (CC) of adults with Drug Susceptible (DS) or Rifampin Resistant (RR) TB. Treating adult, adolescent, child, and pregnant close contacts (CCs) of drug-sensitive tuberculosis (DS-T…
Naidoo K, Dookie N, Naidoo K, Yende-Zuma N, Chimukangara B, et al.
…rent tuberculosis (TB) following TB treatment completion in HIV-infected individuals remains a major public health burden. We assessed the role of various risk factors in mediating the development of recurrent TB and subsequent resistance to antiretroviral therapy and anti-TB dru…
Aner H Khan
… million TB fatalities among Human immune deficiency virus (HIV)-negative people and 208, 000 deaths among HIV-positive people. Literature indicated that treatment adherence for coinfections diseases is difficult due to the complexity, low tolerability, and extended duration of c…
Oriekot A, Sereke SG, Bongomin F, Bugeza S, Muyinda Z
…crobiologically confirmed DS and RR PTB cases stratified by HIV serostatus in Uganda. Methods We conducted a hospital-based retrospective study at the Mulago National Referral Hospital (MNRH) TB wards. All participants had a microbiologically confirmed diagnosis of PTB. CXR findi…
Silvia S. Chiang, Helen E. Jenkins
…escents infected with TB, those <5 years old and those with HIV coinfection have a higher risk of death.2–4 Not only have few researchers quantified the impact of antiretroviral therapy (ART) regarding those with coinfected with HIV,4–6 there are important gaps in our overall kno…
Oriekot Anthony, Senai Goitom Sereke, Felix Bongomin, Samuel Bugeza, Zeridah Muyinda
…ty (n=118, 71.7%) of the participants were seronegative for HIV. Overall, 5/165 (3%) participants had normal CXR. There was no statistically significant difference in the proportion of participants with consolidations (74.8% versus 88.5%; p – 0.203), bronchopneumonic opacities (5…
Putri Immi Rizky Budiyani, Ratna Djuwita, Renti Mahkota, Dwi Handayani
Tuberculosis and HIV are serious health issues that can significantly impact an individual's immune system by evading immune monitoring functions. Research on TB-HIV treatment success, especially in DKI Jakarta province, is still limited. This study aims to assess the treatment s…
National Institute of Allergy and Infectious Diseases (NIAID)
…l suppression when dosed with rifapentine (RPT) 1200 mg for HIV-associated TB. This is an open-label, single arm, phase II, multicenter PK study to investigate the effect of daily RPT 1200 mg on DTG exposure in participants with HIV-associated TB. Adults with HIV with newly diag…
Kuppli Sai Sushma, Devi Madhavi Bhimarasetty, Siva Kumar Lotheti
… treatment of Drug sensitive TB, started initially among TB-HIV co-infected patients in 2017. The present study was taken up to assess the treatment outcomes of Tuberculosis among TB-HIV co-infected patients and certain factors related to the poorer outcome of the treatment. An O…
Jason Farley, PhD, MPH, ANP-BC, Denise Evans, PhD, Norbert Ndjeka, MBChB
…-based outpatient sites among RR-TB patients, regardless of HIV co-infection, as determined by a successful treatment outcome \[H1\]. 2. The proportion of SAEs identified will not significantly differ by blinded, independent review \[H2\]. 3. Patient associated catastrophic costs…
Wang L, Lv H, Zhang X, Zhang X, Bai J, et al.
…s of co-infection between the human immunodeficiency virus (HIV) and drug-susceptible tuberculosis (DS-TB) in different countries, across various age groups and genders. We obtained data on the number of cases, age-standardized incidence rate, age-standardized prevalence rate, ag…
Wang L, Lv H, Zhang X, Zhang X, Bai J, et al.
…s of co-infection between the human immunodeficiency virus (HIV) and drug-susceptible tuberculosis (DS-TB) in different countries, across various age groups and genders. Methods We obtained data on the number of cases, age-standardized incidence rate, age-standardized prevalence …
Ndlovu LN, Peetluk L, Moodley S, Nhamoyebonde S, Ngoepe AT, et al.
…ne, as well as during TB treatment in 79 patients [50 (63%) HIV-positive] with microbiologically confirmed drug susceptible TB undergoing standard treatment. At time of diagnosis, blood neutrophils were highly expanded and surface expression of the neutrophil marker CD15 greatly …
Urooj Ahmad, Anab Arshad, Sara Jadoon, Shahana Saba Salih, Hafsa Ahmed, et al.
…38,723 patients. In 2815 Tuberculosis patients screened for HIV, 4 drug-susceptible and 5 drug-resistant cases were positive for HIV. 8.41% of drug-resistant TB patients were diabetic. Conclusion: The frequency of TB cases is high in Khyber Pakhtunkhwa, especially among 15-24-yea…
Kamatam Meghana, Dollu Rakshitha, Vurugonda sreshta, Kaleru Purnachander
…rculosis) was defined by 1980's since then the emergency of HIV and escalation of Drug sensitive (DS-TB)forms of TB have presented new challenges.To face these challenges, achieve goals like shortening DS -TB treatment improving DR-TB treatment and making combined TB -HIV therapy…
Junhui Wu, Guangqi Han, Disha Zhu, Weixuan Wang, Shaomei Shang
BackgroundHIV and drug-susceptible tuberculosis (DS-TB) co-infection severely affects adolescents and young adults (10-24 years), leading to a significant infectious disease burden, yet this age group remains overlooked. This study assessed the 1990-2021 global, regional, and nat…