Showing 1–25 of 200 documents
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National Institute of Allergy and Infectious Diseases (NIAID)
The purpose of this study is to compare a 6-month regimen of high-dose rifampicin (RIF), high-dose isoniazid (INH), linezolid (LZD), and pyrazinamide (PZA) versus the World Health Organization (WHO) standard of care (SOC) treatment for tuberculosis meningitis (TBM). Rationale: T…
Inbaraj LR, Manesh A, Ponnuraja C, Bhaskar A, Srinivasalu VA, et al.
… up for 1 year after the treatment. DISCUSSION: Current WHO regimens have agents with poor central nervous system drug exposure and is too long. It does not reflect the accumulating evidence in the field. We propose a comprehensive clinical trial incorporating the emerging eviden…
Xueyi Chen, Carlos E Ruiz-Gonzalez, Yuderleys Masias-Leon, Mantej Singh, Oscar J Nino-Meza, et al.
…ains unexplored.Figure 1.Evaluation of rifamycin-containing regimens in the mouse model of TB meningitis.(A) Mice were infected intraventricularly via Burr hole using a syringe and stereotaxic instrument, treatment were initiated two weeks after (designated as day 0) and continue…
Soumya Swaminathan, MD MNAMS
…l trial to assess the efficacy of short course intermittent regimens for the treatment of HIV-associated tuberculosis Phase: Phase III trial Population: 300 HIV positive patients with tuberculosis. Number of Sites:Four 1. Tuberculosis Research Centre, Chennai 2. Government Ge…
Xinxin Zeng, Hao Xu, Aole Li, Juanjuan Liu, Yuhang Wu, et al.
…for childhood tuberculosis (TB), evaluation of TB treatment regimens for children in real-world settings in China remained limited, particularly regarding treatment duration, utilization of second-line anti-TB drugs (SLDs), and adverse events. This study aimed to describe the tre…
Sulis G, Tavaziva G, Gore G, Benedetti A, Solomons R, et al.
…mide (2HRZE/10HR). The comparative effectiveness of shorter regimens is unknown. Methods To inform a WHO guideline update, we undertook a systematic review and meta-analysis to evaluate outcomes from regimens of 6- to less than 12-months' duration that included, at a minimum, iso…
Camilo A. Ruiz-Bedoya, Filipa Mota, Elizabeth W. Tucker, Farina J. Mahmud, Clara Erice, et al.
…atment in animals receiving high- or standard-dose rifampin regimens (Fig. 3). Whole-brain PET and immunolabeling demonstrated spatially compartmentalized inflammation, vascular leak and rifampin exposures (Fig. 4). Longitudinal imaging in the same animals showed a 40% decrease i…
Soumya Swaminathan, MD, PR Narayanan, PhD
…icacy of two different once daily anti-retroviral treatment regimens along with anti-tuberculosis treatment in patients with HIV-1 and tuberculosis - Randomized Controlled Clinical Trial Phase: Phase III trial Population: 180 HIV-1 positive patients with tuberculosis Number of…
Susanna Esposito, Valentina Fainardi, Beatrice Rita Campana, Gaia Giorgia Arnesano, Nicola Principi
…16 years with drug-susceptible TB treated with short-course regimens compared to standard therapy.A shorter treatment regimen, particularly 4-month courses, has been investigated as an alternative to standard therapy in the pediatric population with drug-susceptible TB. Children …
Wasmann RE, Masini T, Viney K, Verkuijl S, Brands A, et al.
Following infection with Mycobacterium tuberculosis , young children are at high risk of developing severe forms of tuberculosis (TB) disease, including TB meningitis (TBM), which is associated with significant morbidity and mortality. In 2022, the World Health Organization (WHO)…
Rovina Ruslami, PhD
…nts with TB meningitis will die. With the current treatment regimens, TBM is fatal in approximately 30-50% of cases, and responsible for severe disability in a similar proportion of survivors. Worldwide, Indonesia the third highest case load of tuberculosis with an estimated 500…
Ruiz-Bedoya C, Mota F, Tucker E, Mahmud F, Erice C, et al.
Abstract Background TB meningitis is the most severe form of tuberculosis (TB), associated with high morbidity and mortality. High-dose rifampin (35mg/kg/day) is safe in adults and substantially improves the bactericidal activity of standard TB regimen. However, there is conflict…
Mengmeng Zhang, Ming-Gui Wang, Jian‐Qing He
Background Tuberculous meningitis is difficult to diagnose and is associated with high mortality. Recently, several studies evaluated the intensified regimen containing higher dose rifampin to treat tuberculous meningitis. However, this topic remains to be concluded. Therefore, t…
Eliana Bicudo, Naira Bicudo, Clarisse Rocha, Joyce Cabral, Gustavo Bicudo
…se infections can be complex, requiring combined antibiotic regimens, oral and intravenous, for prolonged periods, and antimicrobial resistance often poses a challenge. Outpatient Parenteral Antimicrobial Therapy (OPAT) has proven to be an effective approach, allowing patients to…
Surendra K Sharma, MD,PhD
Tubercular pleural effusion is the second most common form of extrapulmonary tuberculosis (EPTB) seen in clinical practice after tuberculosis (TB) lymphadenitis. It is common that after complete treatment of the patient with tubercular pleural effusion with six months of the shor…
Aryal A, Garg B, Mehta N, Shekhar S, Gupta V
…rity in the healing response achieved compared to treatment regimens of longer duration.
Svetlana Degtyareva, Т. А. Кузнецова, В. Н. Зимина
…case demonstrates the clinical efficacy of modern treatment regimens, good compatibility with other drugs and management of adverse events without treatment interruption.
Connie A. Haley, David Ashkin, Charles A. Peloquin
…quires prolonged treatment using less effective, more toxic regimens. Recent trials demonstrated that the all-oral six-month “BPaL” regimen, Bedaquiline, Pretomanid and Linezolid, is 90% effective. In these trials, linezolid-induced hematologic and neurologic toxicity was high us…
…quires prolonged treatment using less effective, more toxic regimens. Recent trials demonstrated that the all-oral six-month “BPaL” regimen, Bedaquiline, Pretomanid and Linezolid, is 90% effective. In these trials, linezolid-induced hematologic and neurologic toxicity was high us…
Xueyi Chen, Carlos E Ruiz-Gonzalez, Yuderleys Masias-Leon, Medha Singh, Charles A Peloquin, et al.
Tuberculous meningitis causes substantial mortality due to limited penetration of antibiotics to the central nervous system and excessive neuroinflammation. This study evaluated clofazimine as an adjunct to the standard first-line tuberculosis regimen, in a mouse model. Mice were…
M. V. S. Subbalaxmi, Suneel Kumar Bagadi, Sandeep Baddepuram, Radhika Soanker
Stevens–Johnson syndrome (SJS) and hepatitis are serious adverse drug reactions following the administration of anti-tuberculosis treatment (ATT). Here, we report a case of a young woman who developed hepatitis and SJS following ATT. Identifying the culprit drug and tailoring the…
Johan Benhard, Gentiane Monsel, Vincent Dubée, Patricia Pavese, Vero Rasoldier, et al.
**BACKGROUND:** Morbidity associated with central nervous system tuberculosis (CNS TB) remains high due to persistent inflammation despite standard-of-care (SOC) treatment, including antituberculosis therapy and corticosteroids. Tumor necrosis factor alpha (TNF-α) is a key …
Kumar RNH, Rao CR, Maradi R, Umakanth S, Sanju SVC, et al.
Aim The study aimed to determine the incidence of adverse drug reactions (ADRs) among newly diagnosed tuberculosis (TB) patients receiving daily drug regimen with fixed-dose combination treatment under the National Tuberculosis Elimination Program. Materials and methods A communi…
Saluja A, Vibha D, Pandit AK, Shukla G, Srivastava AK, et al.
Introduction Corticosteroids are used as adjunctive treatment in tuberculous meningitis (TBM). However, there is no universally accepted regimen, type, duration, or route of steroid administration. Methodology In a randomized open labelled pilot study, TBM patients were divided i…
Li Z, Wang S, Chen X, Ming X, Peng L, et al.
Despite the high prevalence of pulmonary tuberculosis worldwide, extrapulmonary tuberculosis especially cutaneous and osteoarticular tuberculosis occurs rarely, both of which are often difficult to be recognized since their symptoms mimic those of many other cutaneous and osteoar…