Showing 1–25 of 200 documents
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Zh. T. Zhandauletova, Е. И. Никишова, А. O. Мaryandyshev, K. S. Serikbaeva, M. M. Adenov, et al.
…he objective : to assess the safety and compliance with new regimens for preventive treatment of drug susceptible and drug resistant tuberculosis. Subjects and Methods . The study was carried out in Almaty, the Republic of Kazakhstan; 182 patients from the groups facing the high …
Susan Dorman, MD, Payam Nahid, MD, MPH, Susan Swindells, MBBS, Richard Chaisson, MD, Ekaterina V Kurbatova, MD, PhD, MPH
…of this study is to determine whether one or two four-month regimens of tuberculosis treatment are as effective as a standard six-month regimen for treatment of pulmonary tuberculosis (TB). All three regimens are administered daily, seven days each week, with direct observation o…
Lindsay McKenna, Jennifer Furin
… needed on the safety and efficacy of pretomanid-containing regimens, and such data can be found in the paper published in The Lancet Respiratory Medicine by Conor Tweed and colleagues.6Tweed CD Dawson R Burger DA et al.Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide duri…
First Affiliated Hospital of Zhejiang University
…o determine whether the sitafloxacin-containing three-month regimens are as effective as the standard six-month regimen and the four-month rifapentine and moxifloxacin regimen (substitution of rifapentine for rifampin and moxifloxacin for ethambutol) for treatment of pulmonary tu…
Shanghai Pulmonary Hospital, Shanghai, China
…ity (EBA), safety, and tolerability of 4-month short-course regimens containing bedaquiline, moxifloxacin, and pyrazinamide in patients with drug-susceptible tuberculosis. This is a prospective, randomized, controlled, multicenter study planned to enroll 45 rifampicin-susceptible…
Beijing Chest Hospital
…dard of care in China has historically involved 18-20 month regimens, the World Health Organization (WHO) has recently endorsed shorter, all-oral regimens. The BLMZ regimen, composed of Bedaquiline (B), Linezolid (L), Moxifloxacin (M), and Pyrazinamide (Z), demonstrated high effi…
В. П. Гусева, Irina Vasilyeva, V. V. Testov
…dities. Therefore, developing alternative shortened therapy regimens with a favourable safety profile and proven efficacy remains an urgent task. Objective To compare the effectiveness of treatment of pulmonary TB with preserved susceptibility of M. tuberculosis to isoniazid, rif…
Banurekha Velayutham, M S Jawahar, Chandrasekaran Padmapriyadarsini
…ence to our paper entitled ‘4-month moxifloxacin containing regimens in the treatment of patients with sputum-positive pulmonary tuberculosis in South India – a randomised clinical trial’ in the letter ‘False equivalence of four month and six-month ATT regimen: A case of comparin…
Zheng X, Gui X, Yao L, Ma J, He Y, et al.
… the capacity of the short-course approach to identify drug regimens that can shorten the treatment time for tuberculosis.
Feng Z, Miao Y, Peng Y, Sun F, Zhang Y, et al.
…. There is an urgent need to simplify and shorten treatment regimens to reduce interruption and adverse event rates, improve compliance, and reduce costs. Methods ORIENT is a multicenter, randomized controlled, open-label, phase II/III, non-inferiority trial involving DS-TB patie…
Stephanie Palacios, Glenford Refre, Patricio Palmes, Ma. Cecilia Momville
…abases, comparing the 4-month and 6-month anti-TB treatment regimens. RCTs that were published in the English language from 2017-2022 that used drug susceptible TB adult patients were included in the final meta-analysis. We compared the efficacy and safety of the two regimens usi…
Anaam MS, Alrasheedy AA
…rd 6-month regimen was lower than that with the previous TB regimens. However, more efforts are needed to decrease TB recurrence rates further and achieve a durable cure for TB. In addition, healthcare professionals and TB control programs should consider potential risk factors o…
Arinaminpathy N, Gomez GB, Sachdeva KS, Rao R, Parmar M, et al.
…re is increasing interest in future, highly-potent 'pan-TB' regimens against tuberculosis (TB), that may be equally effective in both drug-susceptible and rifampicin-resistant (RR) forms of TB. Taking the example of India, the country with the world's largest burden of TB, we sho…
Shenjie Tang, MD
…udy is to evaluate the safety and efficacy of two shortened regimens for newly diagnosed smear positive drug susceptible pulmonary tuberculosis in comparison to World Health Organization recommended standard 6-month regimen. 1. Design: The study is a multi-center, randomized,con…
Susan Shin-Jung Lee, M.D., Ph.D.
The development of efficacious, safe, and shorter treatment regimens could significantly improve TB management and treatment success rates. This prospective, 3-year, single arm study is to evaluate the efficacy and safety of a short-course, 4-month regimen including isoniazid(H),…
Susan Shin-Jung Lee, MD, PhD
…The development of efficacious, safe, and shorter treatment regimens could significantly improve treatment completion rate and reduce transmission of TB. The current treatment guidelines for drug-susceptible TB from the World Health Organization (WHO), American Thoracic Society (…
John Z Metcalfe, Isabelle R Weir, Kimberly K Scarsi, Alberto Mendoza-Ticona, Samuel Pierre, et al.
**BACKGROUND:** Based on results from preclinical and clinical studies, a five-drug combination of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine was identified with treatment shortening potential for drug-susceptible tuberculosis; the Clo-Fast trial aimed to d…
Reza Yosofi A, Mesic A, Decroo T
…after standardized all-oral short (12 months or less) RR-TB regimens has not yet been systematically reviewed, which is the main objective of this review. Methods This is a systematic review and meta -analysis. PubMed, Web of Science and Google scholar databases were systematical…
Gustavo Velásquez, MD, MPH, Patrick Phillips, PhD, Susan Dorman, MD
…domized to SOC or one of five durations of the experimental regimens while those classified into the higher-risk group will be randomized to receive either SOC or a single fixed duration of the experimental regimen. The lower and higher-risk groups will have the following arms: …
Nisha Wanichwecharungruang, Weerinth Puyati, Thanyanuch Sanchat
Abstract Introduction: The 4-month rifapentine-moxifloxacin (HPMZ) regimen has recently been shown to be as effective as the standard 6-month rifampicin-based regimen for drug-susceptible pulmonary tuberculosis. Clinical trials reported serious adverse drug reactions (ADRs) in on…
Nelly Solomonia, K Vacharadze
…the all anti-TB drugs and to build an appropriate treatment regimens based on complete individual DST profile in timely manner. Initial TB treatment regimen prescribed based on gDST results not in all cases may be compliant with complete DST profile, which may be detected based o…
Alina Malic, Adriana Niguleanu, Tatyana Osipov
Treatment of tuberculosis (TB) includes various therapeutic regimens with a combination of at least four drugs. Adherence to the treatment regimen is crucial for efficacy outcomes based on the achievement of appropriate drug levels. Drug-resistant () strains are mainly favored by…
Zhen Feng, Hailan Wu, Qian Li, Xiaoqiang Zhang, Qingfeng He, et al.
**OBJECTIVES:** High-dose rifamycin (HDR) regimens have demonstrated significant potential in tuberculosis (TB) treatment. This study aims to evaluate the efficacy and safety profile of different HDR regimens. **DESIGN:** Using a systematic review and Bayesian network meta-analy…
Dorman SE, Nahid P, Kurbatova EV, Phillips PPJ, Bryant K, et al.
Background Rifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis. Methods In an open-label, phase 3, randomized, controlled trial involving persons with newly diagnosed pulmon…
Jia-Yih Feng, Chin‐Chung Shu, Shu Min Lin, Ya-Wei Weng, Jui-Kuang Chen, et al.
… epidemic by 2030. Efficacious, safe, and shorter treatment regimens may significantly improve treatment success rates, and reduce TB incidence and mortality. The aim of this study is to evaluate the efficacy and safety of a short-course, 4-month regimen (2HZPM/2HPM) in the Asian…