Showing 1–25 of 129 documents
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Mokhele I, Jinga N, Berhanu R, Dlamini T, Long L, et al.
…cribed the safety of second-line anti-TB medications during pregnancy. We aim to describe TB treatment and pregnancy outcomes among pregnant women receiving second-line anti-tuberculosis treatment for MDR/RR-TB in Johannesburg, South Africa. Methods We conducted a retrospective r…
Muhammad jamshaid Khan, Syed Qamar Uddin, Omer Ahmed
… fatal if left untreated, particularly if contracted during pregnancy. Tuberculosis can affect all stages of female reproduction.3 Therefore, screening and diagnosis are crucial in reducing morbidity and mortality. While pregnancy does not affect disease progression or susceptibi…
О. М. Raznatovska, S. I. Tertishniy, V.G. Syusyuka, A.V. Fedorec, Т. К. Sahaidak, et al.
…ed. However, WHO recommends thorough registering treatment, pregnancy, and postpartum bedaquiline-related outcomes to provide data on appropriate dosing for multidrug-resistant tuberculosis (MDR-TB) treatment during pregnancy and postpartum. However, in the modern literature, the…
Jennifer A Hughes, Flynn McMorrow, Kristina M Brooks, Mauricio Pinilla, Lee Fairlie, et al.
…re no published data on clofazimine pharmacokinetics during pregnancy, and safety data are limited. We present data from pregnant and postpartum women receiving clofazimine for treatment of rifampicin-resistant tuberculosis (RR-TB). **METHODS:** IMPAACT P1026s was an observation…
Jones AJ, Mathad JS, Dooley KE, Eke AC
…rcular (anti-TB) agents and antiretroviral therapy (ART) in pregnancy. Recent findings This review discusses the currently available evidence on the use of anti-TB agents in pregnant PLWH on ART. Pharmacokinetic and safety studies of anti-TB agents during pregnancy and postpartum…
О. М. Raznatovska, A.V. Fedorec, M. O. Shalmina, Тетяна Анатоліївна Грекова
…to update the literature data with the clinical features of pregnancy in multidrug-resistant tuberculosis (MRD-TB) and type 1 diabetes mellitus (T1DM) comorbidities based on an example from own clinical experience. A clinical case of pregnancy course in MRD-TB and T1DM comorbidit…
Maulana Muharam, Dewi Wahyu Firina, Dessy Mizarti
…erse effect of drug, make it management become challenging. Pregnancy with physiological changes in it made pregnant woman susceptible to infection, include tuberculosis infection. Data about MDR TB in pregnancy were not much, because TB screening in pregnancy were not often done…
Maulana Muharam, Dewi Wahyu Firina, Dessy Mizarti
…erse effect of drug, make it management become challenging. Pregnancy with physiological changes in it made pregnant woman susceptible to infection, include tuberculosis infection. Data about MDR TB in pregnancy were not much, because TB screening in pregnancy were not often done…
Marian Loveday, Jennifer Hughes, Nobuhle Mchunu, Nonhlanhla Yende-Zuma, Kerry Holloway, et al.
…prospective, observational study. Maternal TB treatment and pregnancy outcomes were documented through ongoing record reviews and clinical assessments conducted to describe infant outcomes. Using Poisson regression with robust standard errors, we evaluated factors associated with…
Khoza LB, Mulondo SA, Lebese RT
Background Tuberculosis (TB) during pregnancy could confer a high risk for maternal and infant morbidity. Literature indicates that the global burden of active TB disease among pregnant women is not well researched. Statistics for South Africa from WHO give an estimated incidence…
Hui SYA, Lao TT
…m optimal and services for TB needs to be quickly restored. Pregnancy is a unique opportunity to screen and manage TB, and it is an essential step in TB eradication. Early diagnosis and treatment for active disease can reduce maternal and neonatal morbidities and mortality. The m…
Carolina Longo, Karina Felippe Monezi Pontes, Marina Matos de Moura Faíco, Mayra Martins Melo, Gustavo Yano Callado, et al.
…ly in low- and middle-income countries. Tuberculosis during pregnancy represents a major clinical challenge, as physiological and immunological changes associated with pregnancy may obscure symptoms, delay diagnosis, and contribute to adverse maternal and perinatal outcomes. This…
Orazulike N, Sharma JB, Sharma S, Umeora OUJ
…gy especially in low-income countries, which may complicate pregnancy. Although pulmonary TB is more common in pregnancy than extra pulmonary TB (EPTB), EPTB is becoming more common especially in those living with human deficiency virus (HIV) co infection or have other comorbidit…
Liu Y, Jing A, Yu H
…ease among women of childbearing age, with the incidence of pregnancy with tuberculosis (PWT) is approximately 5-7%. PWT has a serious impact on pregnant women, fetuses and infants, and is also one of the main causes of maternal and infant mortality. Early detection, early diagno…
Laniado-Laborín R, Carrera-López K, Hernández-Pérez A
…tation is disputable. Some experts favor the termination of pregnancy, whereas others suggest reducing the dose of teratogenic drugs or even suspending the regimen during pregnancy. There have been no clinical trials on the subject, but case reports and case series show excellent…
Hughes JA, Pinilla M, Brooks KM, Eke AC, Stek A, et al.
…quinolones, but data on long-term exposure during and after pregnancy are limited. We examined the pharmacokinetics and safety of levofloxacin in an observational cohort of pregnant and postpartum women receiving treatment for RR-TB. Methods Participants were enrolled in their se…
Alene KA, Jegnie A, Adane AA
… to examine the impact of MDR-TB and its medications during pregnancy on maternal and perinatal outcomes. Search strategy PubMed, Scopus and Web of Science databases were searched from earliest to February 2020. Selection criteria Records were screened based on pre-defined select…
Sharon Sawe, Lufina Tsirizani, Richard Court, Kamunkhwala Gausi, Asanda Poswa, et al.
…is (RR-TB). There are limited data describing the effect of pregnancy on the pharmacokinetics of levofloxacin. We aimed to characterize the pharmacokinetics of levofloxacin in adults with RR-TB, including the effect of pregnancy. We pooled data from two studies conducted in adult…
Shiu JR, Min A, Kiang TKL
…able data on the use of anti-tuberculosis (TB) drugs during pregnancy, with a focus on treatment outcomes, safety, and pharmacokinetics. This qualitative, narrative review was based on literature searches in Medline, Pubmed, Embase, and Google Scholar (from their inception to 13 …
Irene Sinta Febriana, Sayugo Atikah, Sri Pudyastuti
…ory and also cardiovascular complication. Its occurrence in pregnancy is uncommon but is highly associated with higher mortality and morbidity for both maternal and fetal.Case Report: We report a case of 24 year old primigravida in National Respiratory Center Hospital, diagnosed …
Irene Sinta Febriana, Sayogo Atikah, Sri Pudyastuti
…ory and also cardiovascular complication. Its occurrence in pregnancy is uncommon but is highly associated with higher mortality and morbidity for both maternal and fetal. Case Report : We report a case of 24 year old primigravida in National Respiratory Center Hospital, diagnose…
Stroeken Y, Broekhuijsen K, Leyten E, Hermes W
… tube and endometrial pathology leading to subfertility and pregnancy loss. This case report describes a 34-year-old woman from Ivory Coast who was diagnosed with intrauterine tuberculosis after hysteroscopic evacuation of suspected retained placental tissue following an immature…
Lotia Farrukh I, Lachenal N, Adenov MM, Ahmed S, Algozhin Y, et al.
… normal birth weights. Effective MDR/RR-TB treatment during pregnancy can improve maternal outcomes without harming neonates.
Court R, Gausi K, Mkhize B, Wiesner L, Waitt C, et al.
Aims We aimed to explore the effect of pregnancy on bedaquiline pharmacokinetics (PK) and describe bedaquiline exposure in the breast milk of mothers treated for rifampicin-resistant tuberculosis (TB), where there are no human data available. Methods We performed a longitudinal P…
U. Nagashree, Charumathi, U. Meenakshisundaram
…ed frequency of maternal disability, hospitalisation during pregnancy, foetal growth retardation, prematurity, low-birth weight and increased perinatal mortality. As information on outcome of pregnancy among women with extra pulmonary TB is limited; various medical and surgical o…