Pregnancy and Birth Outcomes in Patients With Multidrug-Resistant Tuberculosis Treated With Regimens That Include New and Repurposed Drugs
Lotia Farrukh I, Lachenal N, Adenov MM, Ahmed S, Algozhin Y, Coutisson S, Garavito ES, Hewison C, et al. (28 authors)
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024-01
Abstract
Among 43 pregnant women receiving multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment with bedaquiline and/or delamanid, 98% had favorable treatment outcomes. Of 31 continued pregnancies, 81% had live births with no reported malformations, and 68% of neonates had normal birth weights. Effective MDR/RR-TB treatment during pregnancy can improve maternal outcomes without harming neonates.
MeSH terms
- Humans
- Tuberculosis, Multidrug-Resistant
- Antitubercular Agents
- Treatment Outcome
- Clinical Protocols
- Pregnancy
- Infant, Newborn
- Female
- Live Birth
- Diarylquinolines