Showing 1–25 of 200 documents
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Daniela Russo
Despite its ancient origins, tuberculosis (TB) remains a major public health problem. In the pediatric population, the prevention and diagnosis of TB is considered a major challenge. For this reason, this scoping review will be conducted in order to systematically map the researc…
Gaensbauer J, Broadhurst R
Purpose of review Tuberculosis is leading cause of global morbidity and mortality and a significant proportion of the burden of disease occurs in children. In the past 5 years, a number of innovations have improved the diagnosis and treatment for children with both latent tubercu…
Roxana Mansour Ghanaie, Abdollah Karimi, Leila Azimi, Seddon James, Mahshid Nasehi, et al.
… Although the World Health Organization has recommended the diagnosis and prophylactic treatment of latent tuberculous infection (LTBI) in child household contacts of tuberculosis (TB) cases, the national programs in high-burden TB regions rarely implement adequate screening of t…
Ghanaie RM, Karimi A, Azimi L, James S, Nasehi M, et al.
… Although the World Health Organization has recommended the diagnosis and prophylactic treatment of latent tuberculous infection (LTBI) in child household contacts of tuberculosis (TB) cases, the national programs in high-burden TB regions rarely implement adequate screening of t…
Özlem Tezol
Objectives: Pediatric tuberculosis is a major public health problem. Malnutrition characterized with wasting is prevalent among pediatric tuberculosis patients. We aimed to review pediatric tuberculosis cases by considering their nutrition manifestations. Materials and Methods: T…
Tulane University
Pediatric tuberculosis (TB) continues to pose diagnostic challenges in low- and middle-income countries with high rates of TB disease, due to the well-described impact of paucibacillary disease in children, and current TB culture and polymerase-chain reaction tests are of limited…
Sayyahfar S, Davoodzadeh F, Hoseini R, Rahimzadeh N, Otukesh H
…till a valuable diagnostic tool with high accuracy rate for diagnosis of LTBI in children candidates for renal transplantation and can still be used as an accurate test for screening Mycobacterium TB infection.
Krunal Patel, Kinjal Patel, Pooja Gandhi, Bhavini Rathwa, Dipak M. Nakum
Introduction: Tuberculosis is a chronic infectious disease caused by predominantly Mycobacterium tubercle bacilli. Pediatric tuberculosis is among the top 10 causes of death in children. India accounts for one fourth of the global tuberculosis burden, standing one among the thirt…
Francesca Montagnani, PhD, MD
…T, Cellestis Limited, Carnegie, Victoria, Australia) in the diagnosis of tuberculosis (TB - active or latent) in pediatric subjects (0 and 17 year)s recently exposed to infection (indicated as "contacts") or with clinical suspicion of active TB, and to compare the results obtaine…
Wiwiek Setiowulan, redi rulandani, Helmy Rachman
Pediatric drug reaction with eosinophilia and systemic symptoms (DRESS) is a life-threatening uncommon disease that can be difficult to diagnose. We present a case of a 10-year old girl with ten days of high fever during her fifth week of ATT (consisting of isoniazid, rifampicin,…
Druszczynska M, Seweryn M, Wawrocki S, Pankowska A, Kulbachko A, et al.
Background Accurate diagnosis of tuberculosis (TB) in children continues to be challenging, primarily due to the low bacterial load characteristic of the disease and the obstacles in collecting sputum samples. Furthermore, detecting cases of latent Mycobacterium tuberculosis (M.t…
Kanjanaphan T
Background Tuberculosis (TB) is an important public health problem, and airborne transmission is easily transmitted. Latent TB infection (LTBI) detection and treatment is the key strategy to prevent TB. Objective This study aimed to perform contact investigation of LTBI in health…
Patricia Comella-del-Barrio, José Luis Izquierdo-García, Ramón Campos‐Olivas, Clara M. Santiveri, Jesús Ruı́z-Cabello, et al.
Children’s paucibacillary tuberculosis (TB) and their difficulty to expectorate leads to low diagnostic sensitivity. Most TB in children are diagnosed by clinical scoring systems limited by the TB clinical presentation. Pediatric TB diagnosis research should be focused on new bio…
Mase A, Ryan S, Mader G, Alvarez A, Armitige L, et al.
…or Disease Control and Prevention (CDC) funds five Regional Tuberculosis Training and Medical Consultation Centers (RTMCCs) that provide training and consultation for tuberculosis (TB) control and management. RTMCC utilization for assistance with diagnosis and management of TB in…
Ma HW, Lee HS, Ahn JY
The incidence of tuberculosis remains high in South Korea; the management of latent tuberculosis infection (LTBI) has become the prime target for reducing the infection rate. The management of pediatric LTBI is especially crucial because children can serve as a long-term source o…
Muhammad Abbud Widitaputra, Retno Asih Setyoningrum, Agus Harianto
Tuberculosis, caused by Mycobacterium tuberculosis, is transmitted through the release of bacteria into the air via respiratory activities, such as breathing and coughing. Untreated latent tuberculosis can act as a reservoir for future infections. Remote regions like Masalembu en…
Stefani Candra Firmanti, Rina Triasih, Tri Wibawa, Sofia Mubarika Haryana
BACKGROUND: The diagnosis of tuberculosis (TB) in children is challenging by the absence of a practical gold standard. Interferon (IFN)-ginducible protein 10 (IP-10) is a chemokine that may serve as the leading candidate marker in child TB diagnosis. The aim of this study is to a…
Cai Q, Shen X, Li H, Yao C, Sun N, et al.
Background Mycobacterium tuberculosis (Mtb)-specific perforin were significantly increased in patients with tuberculosis. This study aims to evaluate the diagnosis value of Mtb-specific perforin in pediatric patients with tuberculosis. Methods Diagnostic performance of perforin l…
Meyer Children's Hospital IRCCS
…s were reported in 2020, of which 1 million occurred in the pediatric population. However, epidemiological data available on tuberculosis (TB) in pediatric age are extremely limited due to diagnostic challenges in this patient category. Furthermore, children are almost never incl…
E. P. Еremenko, Е. А. Бородулина, I. A. Sergeeva, D.А. Kudlаy, B. E. Borodulin
…ests (Mantoux test with 2 TU PPD-L and diaskintest) for the diagnosis of tuberculosis infection, in vitro tests are used. One of these tests is T-SPOT.TB being more widely used in recent years. The objective : to evaluate the effectiveness of T-SPOT.TB test for early detection of…
Anastasia Y. Starshinova, И. Ф. Довгалюк, Ulia Ovchinnikova, Анна Старшинова, P. K. Yаblonskiy
<b>Introduction:</b> Early diagnosis of TB infection in children is complicated due to poor clinical signs, minor X-ray abnormalities, and absence of bacterial excression. Potential of Mantuox 2 TE test in population with common BCG vaccination is limited due to its low diagnosti…
Deepak V. Sawant, Shivaji H. Pawar
Tuberculosis (TB) is a transmissible disease caused by Mycobacterium tuberculosis. TB infection affects mainly upper respiratory organs such as the lungs, so-called pulmonary TB. They can also affect multiple organs like bones, joints, skin, and genital organs, etc., are extrapul…
Adusumelli Y, Tabatneck M, Sherman S, Lamb G, Sabharwal V, et al.
…00 US children and adolescents are estimated to have latent tuberculosis (TB) infection. Identifying facilitators and barriers to engaging in TB infection care is critical to preventing pediatric TB disease. We explored families' and clinicians' perspectives on pediatric TB infec…
Hongmei Chen, Changxing Shen, Dan Li
…Introduction: Children exhibit heightened susceptibility to tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (MTB) infection. Among the interferon-gamma release assays (IGRAs) recommended by the World Health Organization (WHO) for MTB infection screening is the n…
Nadege Nziza, Wonyeong Jung, Tina Chen, Yixiang Deng, Kees L M C Franken, et al.
**BACKGROUND:** Tuberculosis (TB), caused by(Mtb), is among the leading causes of death from an infectious agent among children worldwide. Children represent a particularly vulnerable population due to the greater challenges in diagnosis and the higher risk of progression to seve…