Showing 1–25 of 29 documents
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Kendra Brett, Camille Dulong, Melissa Severn
…eing pulmonary TB.,Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual who has the M. tuberculosis infection in which the bacteria are alive but are not currently causing active TB disease. Persons with LTBI do …
Amyn A. Malik, Mercedes C. Becerra, Hamidah Hussain
…rnational guidance underscore the benefits of TB preventive treatment for household contacts of all ages [[1]World Health OrganizationWHO operational handbook on tuberculosis: module 1: prevention: tuberculosis preventive treatment. World Health Organization, Geneva, Switzerland2…
Brett K, Dulong C, Severn M
…ing pulmonary TB., Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual who has the M. tuberculosis infection in which the bacteria are alive but are not currently causing active TB disease. Persons with LTBI do …
Alissar Al Khatib, Salwa Hassanein, Mohammad Almari, Mohamad Koubar, Suha Fakhreddine
…s was highly recommended by World Health Organization (WHO) guidelines (WHO, 2023). Although death is preventable by successful treatment, a great number of TB survivors experience post-tuberculosis conditions, with an increase of long-term disability evidence in this population …
Lee A, Xie YL, Barry CE, Chen RY
Guidelines on the treatment of tuberculosis (TB) have essentially remained the same for the past 35 years, but are now starting to change. Ongoing clinical trials will hopefully transform the landscape for treatment of drug sensitive TB, drug resistant TB, and latent TB infection…
Kendra Brett, Camille Dulong, Melissa Severn
…ion of TB bacteria.Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual who has the M. tuberculosis infection in which the bacteria are alive but are not currently causing active TB disease. Persons with LTBI do …
Brett K, Dulong C, Severn M
…on of TB bacteria. Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual who has the M. tuberculosis infection in which the bacteria are alive but are not currently causing active TB disease. Persons with LTBI do …
Marais BJ
…d TB, but the establishment of functional TB prevention and treatment programs for children remains challenging. Barriers to TB prevention include: 1) non-implementation of existing guidelines, 2) perceived inability to rule out active TB with fear of creating drug resistance and…
Valentina Aksenova, Nadezda Klevno, Alexey Kazakov, А. Д. Пахлавонова
…to WHO, the effectiveness of currently available preventive treatment schemes for people of the risk groups is from 60 to 90%. However, up to date, preventive treatment guidelines have not been developed for people who have been in contact with patients with MDR-TB. Objective of …
Vladimir Milanov, Nikolay Yanev, Natalia Gabrovska, Denitsa Dimitrova, Elizabeta Bachiyska, et al.
Isoniazid (H; INH) is an important first-line drug for the treatment of active tuberculosis (TB) and latent TB infection because of its potent early bactericidal activity against Мycobacterium tuberculosis. Currently, TB resistant to INH, alone or in combination with other drugs,…
Alzahabi KH, Usmani O, Georgiou TK, Ryan MP, Robertson BD, et al.
…sulting with a mortality approximating 1.5 million. Current treatment guidelines recommend oral administration of a combination of first-line anti-TB drugs for at least 6 months. While efficacious under optimum conditions, 'Directly Observed Therapy Short-course' (DOTS) is not wi…
Jyoti S. Mathad, Sylvia M. LaCourse, Amita Gupta
…ganization (WHO) recommends improving access to testing and treatment of latent TB infection (LTBI) [1]. Despite recent epidemiologic studies demonstrating an approximately twofold increased risk of active TB in peripartum women [2], and poor outcomes associated with TB during pr…
R. De Luca E Tuma, Amina Jama, Susan Dart, Verónica White, Christabelle Chen, et al.
…of MDR-TB in East London remain high. There are no existing guidelines for treating close contacts of newly diagnosed MDR-TB cases in low TB incidence countries. This study aims to analyze the rates of MDR-TB among close contacts of TB index cases with pulmonary MDR-TB in East Lo…
Suman Majumdar, Rina Triasih, Stephen M. Graham
…is by 2030 cannot be achieved without a strategy to address latent infection that is subclinical or quiescent.2Rangaka MX Cavalcante SC Marais BJ et al.Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection.Lancet. 2015; 386: 2344-2353Summary …
Alberto L. García‐Basteiro, Helen E. Jenkins, Molebogeng X. Rangaka
…uggest that around 25% of the world's population could have latent tuberculosis infection,2Houben RMGJ Dodd PJ The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling.PLoS Med. 2016; 13e1002152Crossref PubMed Scopus (933) Google Scholar 5–…
Jun YK, Chun J, Kang EA, Lee HJ, Im JP, et al.
… factor (anti-TNF) is an effective biological agent for the treatment of moderate-to-severe active ulcerative colitis (UC) refractory to conventional therapy. On the other hand, anti-TNF therapy is strongly associated with a potential risk of tuberculosis (TB). Active TB is a cri…
Nathan Kapata, Alimuddin Zumla
An estimated 1·7 billion people globally are latently infected with Mycobacterium tuberculosis.1WHOGlobal tuberculosis report 2021.https://www.who.int/publications/i/item/9789240037021Date: October 14, 2021Date accessed: March 19, 2022Google Scholar Latent M tuberculosis infectio…
Neil W. Schluger
…treated with isoniazid (INH) according to Peruvian national guidelines in Peru Topics discussed include vaccine candidates in phase trials after cases of coronavirus disease (COVID-19), clinical trials examining treatment for latent TB and infectious disease challenge in hospital…
Diel R, Nienhaus A
…stant TB (MDR-/RR-TB). Methods Based on the current therapy guidelines of the German Central Committee against Tuberculosis and most recent renumeration data of the Statutory Health Insurances (SHI), this study estimates the mean in- and outpatient costs per adult infectious pulm…
Baker JJ, Nahar R, Petroelje BK, Goswami ND, Lardizabal AA
Latent tuberculosis infection (LTBI) constitutes an important public health problem because of risk of progression to TB disease. Effective treatment of multi-drug resistant (MDR) LTBI would prevent progression to MDR TB disease, which would improve patient and public health outc…
Gavin Churchyard, MBBCh MMed FRCP FCP(SA) PhD, Amita Gupta, MD, MHS, Anneke Hesseling, MD, PhD, Susan Swindells, MBBS
…-risk HHCs are those with HIV or non-HIV immunosuppression, latent TB infection, and young children below the age of 5 years. This study will compare the efficacy and safety of 26 weeks of delamanid (DLM) versus 26 weeks of isoniazid (INH) for preventing confirmed or probable ac…
Desilva M, Moore N, Thai D, Grimm M, Sabuwala N, et al.
…cted CIs for infectious cases. We created outbreak specific guidelines for screening and management of contacts, and partnered with various agencies to increase MDR TB awareness. Results WGS results were consistent with an MDR TB outbreak that included 10 cases (70% pulmonary) as…
Fiore V, De Vito A, Martineková P, Princic E, Geremia N, et al.
… evaluate a screening program, with active case-finding and treatment for active tuberculosis (TB), latent tuberculosis infection (LTBI), blood-borne viruses (BBV), and sexually transmitted diseases (STDs) among refugees living in facility centers. Methodology We collected data o…
Jones AJ, Mathad JS, Dooley KE, Eke AC
…HIV (PLWH) are at especially high risk for progression from latent tuberculosis infection (LTBI) to active tuberculosis (TB) disease. Among pregnant PLWH, concurrent TB increases the risk of complications such as preeclampsia, intrauterine fetal-growth restriction, low birth weig…
Huang GKL, Pawape G, Taune M, Hiasihri S, Ustero P, et al.
… for MDR-TB has led to much needed changes in international guidelines promoting the use of newer TB drugs and regimens for MDR-TB, however, there remains a significant implementation gap. Due to the complexity of treating MDR-TB, management of cases is often supported by an expe…