Showing 1–25 of 200 documents
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Goscé L, Bitencourt J, Gupta RK, Arruda S, Rodrigues LC, et al.
…e of implementing different preventive strategies alongside treatment of TB disease, including BCG vaccination and treatment of latent tuberculosis infection (LTBI). Large-scale population level LTBI treatment is not currently part of WHO guidelines which recommend LTBI treatment…
Eskild Petersen, Martin Rao, Giuseppe Ippolito, Gina Gualano, Jeremiah Chakaya, et al.
… by TB by 2022, and to conduct research on new diagnostics, treatments and vaccines required to achieve global TB control (Tiberi et al., 2018Tiberi S. Petersen E. Maeurer M. Ntoumi F. Yeboa-Manu D. Mwaba P. et al.Taking forward the Stop TB Partnership and World Health Organizati…
Amyn A. Malik, Mercedes C. Becerra, Hamidah Hussain
…rnational guidance underscore the benefits of TB preventive treatment for household contacts of all ages [[1]World Health OrganizationWHO operational handbook on tuberculosis: module 1: prevention: tuberculosis preventive treatment. World Health Organization, Geneva, Switzerland2…
Brett K, Dulong C, Severn M
…ing pulmonary TB., Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual who has the M. tuberculosis infection in which the bacteria are alive but are not currently causing active TB disease. Persons with LTBI do …
Dick Menzies
…icrobiological investigation negative, TST positive receive latent TB infection (LTBI) treatment. If microbiological investigation is positive, they will be offered treatment for active TB. For children under 5 years of age in Brazil, sputum induction will be performed for bacter…
Kendra Brett, Camille Dulong, Melissa Severn
…eing pulmonary TB.,Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual who has the M. tuberculosis infection in which the bacteria are alive but are not currently causing active TB disease. Persons with LTBI do …
Dick Menzies
… standard rifampin regimen when taken for 4 months to treat latent TB (LTBI). However, there is insufficient evidence on the optimal dose of rifampin that has similar efficacy as the standard 4-month rifampin regimen without jeopardizing safety or affecting completion rates. Obj…
Helen Ayles, Professor
…ination HIV prevention, including universal HIV testing and treatment, combined with population screening for active TB on the burden of TB. The HPTN071(PopART) trial,a cluster randomised trial in 21 communities in Zambia and South Africa with a population size of approximately 1…
Brett K, Dulong C, Severn M
… (i.e., coughing). There are two distinct categories of TB, latent TB infection (LTBI) and active TB disease (also known as active TB)., A person with LTBI is not contagious as they cannot spread the bacteria to others and do not possess any visible symptoms. However, persons wit…
Kendra Brett, Camille Dulong, Melissa Severn
… (i.e., coughing). There are two distinct categories of TB, latent TB infection (LTBI) and active TB disease (also known as active TB)., A person with LTBI is not contagious as they cannot spread the bacteria to others and do not possess any visible symptoms. However, persons wit…
Mohd Fazeli bin Sazali, MD, MPH
…s to control TB epidemic. However, prolonged duration of TB treatment raised issues of non-adherence. Non-adherence to TB therapy could negatively affect clinical and public health outcomes. Introduction of Direct Observed Therapy (DOT) has been used as a standard strategy to imp…
All India Institute of Medical Sciences
…adapted from the induction phase dosing schedule of the ACR guidelines for the management of Lupus nephritis. The guidelines recommend 500 to 1000 mg/m2 BSA of cyclophosphamide. So the investigators decided to use 750 mg/m2 of the drug rounded off to the higher 50 mg. Pathogenes…
Dick Menzies, MD
…ur study rationale is based on: 1. Tuberculosis Preventive Treatment (TPT) is given to healthy people and needs to be safe; 2. Tuberculosis Preventive Treatment (TPT) with shorter regimens are superior with respect to acceptance, completion, and costs; 3. 4 months of Rifampin 10…
Soumya Chatterjee, MD
…berculosis (Mtb) reactivates replication in people who have latent tuberculosis infection (LTBI). Only 5 to 10% of subjects with LTBI develop active TB Infection over their lifetime. Current US guidelines recommend treating everyone with LTBI to stop progression to active TB. As …
Brett K, Severn M
…ult in active TB disease, producing instead an asymptomatic latent TB infection. People with latent TB cannot spread the disease to others, but they can develop active TB disease. Symptoms of active TB disease include a bad cough, fever, and weight loss. The current treatment for…
Kendra Brett, Melissa Severn
…ult in active TB disease, producing instead an asymptomatic latent TB infection. People with latent TB cannot spread the disease to others, but they can develop active TB disease. Symptoms of active TB disease include a bad cough, fever, and weight loss.The current treatment for …
Soedarsono Soedarsono
…rganization (WHO) guideline recommended a combination of TB treatment consisting of 2 months of intensive phase with isoniazid (H), rifampisin (R), pyrazinamid (Z), and ethambutol (E), followed by 4 months of continuation phase with HR daily. WHO has updated DR-TB treatment guide…
Margherita Bracchi, Clare van Halsema, Frank A. Post, Funmi Awosusi, Alison Barbour, et al.
These guidelines are dedicated to the memory of Professor Stephen Lawn, a scientist and clinician whose pioneering work helped transform the management of TB in people living with HIV. The overall purpose of these guidelines is to help physicians manage adults with tuberculosis (…
Kerrigan D, Tudor C, Motlhaoleng K, Lebina L, Qomfu C, et al.
…est, Quantiferon-TB Gold In-Tube Test (QGIT), to screen for latent TB compared to the Tuberculin Screening Test (TST) among PLHIV in South Africa. Methods Fifty-six qualitative interviews were conducted with PLHIV and clinical providers participating in the TEKO trial. We explore…
Calvin Young, Melissa Severn
…e 554 per 100,000 population.There are two stages to TB: 1) latent TB infection, and 2) active TB infection. Latent TB typically occurs immediately following exposure to the bacteria. Although an individual who has latent TB infection will not exhibit any symptoms and they are no…
Young C, Severn M
… 554 per 100,000 population. There are two stages to TB: 1) latent TB infection, and 2) active TB infection. Latent TB typically occurs immediately following exposure to the bacteria. Although an individual who has latent TB infection will not exhibit any symptoms and they are no…
Marco Antivalle, MD
…e of Quantiferon-TB Gold (QFT-G) assay in the screening for latent tuberculosis infection (LTBI) in rheumatologic patients due to start or on treatment with TNFα antagonists. The results of QFT-G will be compared to tuberculin skin testing (TST) and correlated to clinical and dem…
Amish Talwar, Clarisse A. Tsang, Sandy F. Price, Robert Pratt, William L. Walker, et al.
…ntury without greatly increased investment in detection and treatment of latent TB infection (LTBI).1Menzies NA Cohen T Hill AN et al.Prospects for tuberculosis elimination in the United States: results of a transmission dynamic model.Am J Epidemiol. 2018; 187: 2011-2020Crossref …
Sumaiya Islam, Dona A. Kiriella, Olutobi Oridota, Avika Dixit
…wide. The World Health Organization (WHO) routinely updates guidelines for the treatment to lateen tuberculosis infection (LTBI) in children with the last update provided in 2020. The objective of our study was to assess the impact of these updates on national LTBI guidelines dev…
Torres T, Brembilla NC, Langley RG, Warren RB, Thaçi D, et al.
…unocompetent individuals, the microorganism can remain in a latent, non-contagious form, however, it may become active under conditions of immunosuppression. Tumour necrosis factor (TNF) inhibitors, which are frequently used for the management of immune-mediated disorders like ps…