Showing 1–25 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Itu Singh, Utpal Sengupta
… continued till the appearance of primary and secondary DDS resistance during the 1970s.[45] Most of these DDS-resistant cases originated from fully treated relapse cases. However, it was noted that low doses of dapsone and irregular treatment were the major causes of relapse.[5]…
Ketema DB, Alene M, Assemie MA, Yismaw L, Merid MW
Background The emergency of drug resistant tuberculosis is a major public health concern worldwide including Ethiopia. However, little is known about risk factors of mortality among drug resistant tuberculosis patients in the study site. Thus, this study was aimed to estimate the…
Yang J, Lu Y, Chen Y, Wang Y, Wang K
Objective This study aims to analyze the drug resistance spectrum, genetic diversity, and transmission dynamics to provide a basis for the prevention and control of drug-resistant (DR) tuberculosis (TB) epidemics. Methods This retrospective study is based on routine national drug…
Cuiyu Liu, Suping Li, Pan Baoshan, Hui Xing, Liang Bohui, et al.
Objective To understand the prevalence of drug resistance in pulmonary tuberculosis (TB) patients in Jiamusi, Heilongjiang province, and provide reliable references for the prevention and control of TB. Methods Mycobacterium tuberculosis strains isolated from 575 TB cases collect…
Guo Liang Gan, Matthew H. Nguyen, Elijah Willie, Mohammad H. Rezaie, Brian Lee, et al.
Abstract The efficacy of antibiotic drug treatments in tuberculosis (TB) is significantly threatened by the development of drug resistance. There is a need for a robust diagnostic system that can accurately predict drug resistance in patients. In recent years, researchers have be…
Shah V, Yogesh M, Kothari DR, Gandhi RB, Nagda JJ
Background Characterizing risk factors for drug-resistant tuberculosis (TB) is critical to guide targeted interventions in high-burden settings like India. We aimed to identify socioeconomic, lifestyle, and clinical factors associated with drug-sensitive and drug-resistant TB acq…
Lei Wang, Zhidong Teng, Ramziya Rifhat, Kai Wang
Tuberculosis has been prevalent in Xinjiang with severe drug resistance situation. It is unclear that which Mycobacterium tuberculosis (M.tb) infections (drug sensitive or drug resistant) most affected the tuberculosis incidence, how to identify the relative contribution of prima…
М.В. Ураксина, Petr Rogozhkin, Ekaterina Eremenko
…ic indicators for tuberculosis, the number of patients with drug-resistant forms of tuberculosis is increasing, which complicates and prolongs the treatment of such patients. The aim of the work is to study the drug resistance of Mycobacterium tuberculosis obtained from surgical …
Tarun Narang, Divya Kamat, Vishal Thakur, Mallika Lavania, Itu Singh, et al.
…dia. It is believed that bacilli persisting even after multidrug therapy can cause relapse; recently, however, drug resistance as a cause for recurrences and chronic erythema nodosum leprosum (ENL) has been speculated. AIM: To study drug-resistance patterns in cases of leprosy re…
Derner, Catherine Marie
…t challenges to effective treatment due to the emergence of drug-resistant strains. The prevalence and mechanisms of drug resistance amplification in TB remain areas of ongoing research and debate. This study investigated the consequences of suboptimal treatment on the acquisitio…
Dennis Mujuni, Willy Ssengooba, Ivan Ibanda, Joel Kabugo, Dianah Linda Kasemire, et al.
…nt success rates stemming from the emergence of second-line drug resistance. We aimed at determining the usefulness of second-line drug (SLD) resistance markers as proxy indicators of time to sputum culture conversion; a renowned predictor of Tuberculosis treatment outcome, among…
Naila Samad, Ghulam Mustafa Wardak, Fakhra Batool, Hadeel Ahmed Kenoosh, Nnamdi C. Opara, et al.
Background. Pakistan is high burden drug resistant tuberculosis (DR-TB) country. For devising a treatment regimen and optimizing empirical drug therapy, the local epidemiology and drug resistance patterns are needed to be considered. Objectives. To evaluate the drug resistance pa…
Zeng X, Kwok JS, Yang KY, Leung KS, Shi M, et al.
Background Drug resistance in Mycobacterium tuberculosis (MTB) is one of the major challenges in tuberculosis (TB) treatment. However, known mutations cannot explain all of the cases of resistance and little research has focused on the relationship between insertions / deletions …
Nimmo C, Millard J, Faulkner V, Monteserin J, Pugh H, et al.
Mycobacterium tuberculosis has acquired drug resistance to all drugs that have been used against it, including those only recently introduced into clinical practice. Compared to other bacteria, it has a well conserved genome due to its role as an obligate human pathogen that has …
Maeda T, Kawada M, Sakata N, Kotani H, Furusawa C
Drug-resistant tuberculosis (TB) is a growing public health problem. There is an urgent need for information regarding cross-resistance and collateral sensitivity relationships among drugs and the genetic determinants of anti-TB drug resistance for developing strategies to suppre…
Aarav Sinha, Jothsna Kethar, Dr.Rajagopal Appavu
Drug-resistant tuberculosis (TB) poses a significant global health challenge, affecting millions worldwide. Annually, around half a million individuals develop drug-resistant TB, underscoring the urgency of addressing this issue. Treating drug-resistant TB is complex and lengthy,…
V Bajiya, C R Choudhary, G Purohit, A Kuwal, A Mohanty
<b>Background:</b> Drug resistant tuberculosis is a serious public health problem in India. Due to inappropriate use, resistance to FQs has increased, which is a major threat to control TB worldwide. FQ resistance is caused by mutation in gyrA and gyrB genes of Mycobacterium tube…
Ifrah Amjad, Saba Riaz
…rganisms. Microorganisms have noteworthy amplitude to offer resistance to antimicrobial agents and becoming an awful public health plight. The rising probability of infections is attributed to the ability of microbes conferring drug resistance. Drug resistance is a horrible capac…
Anderson K, Pietersen E, Dheda K, van der Heijden YF
Background Simplified drug-resistant tuberculosis (DR-TB) treatment outcome definitions, mostly centred around receipt of treatment and sputum culture status at 6 months after treatment initiation, have been proposed, but have not been widely evaluated in resource-limited setting…
Deepika Rai, Priyanka Padwal, Priyanka Purkayastha, Sarika Mehra
ABSTRACT Resistance to multiple drugs is one of the significant barriers in the treatment of tuberculosis (TB). Knowledge of mechanisms of resistance is important to design effective treatment strategies. While mutations in genes coding for drug targets are thought to be the prim…
Paulina M. Mejía‐Ponce, Elsy Janeth Ramos-González, Axel Alejandro Ramos-García, Edgar E. Lara‐Ramírez, Alma R. Soriano-Herrera, et al.
…es worldwide. New diagnostic tools and approaches to detect drug-resistance must be introduced by 2025 to achieve the End-TB Strategy goals set for 2030 by the WHO. Genomic epidemiology of TB has allowed the expansion of catalogs listing genetic signatures of Mtb drug-resistance.…
Álvaro Auñón, Santiago Gabardo, Carmen Álvaro, Ricardo de la Concha, Javier Sanado, et al.
…thetic joint infection (PJI), but the outcome impact of key resistance phenotypes is unclear. Methods: We retrospectively studied consecutive monomicrobial S. epidermidis PJIs treated at a tertiary hospital (2010–2024). PJI was defined according to 2018 ICM criteria. Success requ…
Yadav M, Jain AK, Singhal R, Chadha M, Arora VK, et al.
…ground There is paucity of data on incidence and pattern of drug resistance in spinal TB. This prospective observational study was conducted to document the incidence and drug-resistance pattern among primary and presumptive resistant cases. Methods 59 consecutive cases diagnosed…
Jiang Z, Lu Y, Liu Z, Wu W, Xu X, et al.
Prediction of antimicrobial resistance based on whole-genome sequencing data has attracted greater attention due to its rapidity and convenience. Numerous machine learning-based studies have used genetic variants to predict drug resistance in Mycobacterium tuberculosis (MTB), ass…
Rashmi Jindal, Itu Singh, Sadhana Bhardwaj, Payal Chauhan
…n. However, an additional problem emerging is antimicrobial resistance (AMR) to anti-leprosy drugs, especially rifampicin that forms the backbone of WHO multi-drug therapy. WHO recommends testing for AMR in all relapse cases and a sample of new multibacillary (MB) cases.[2] Howev…