Showing 1–25 of 200 documents
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Jieying Wang, Jinhui Dong, Zhuolin Chen, Yuni Xu, Wenhua Qiu, et al.
**OBJECTIVE:** Multidrug-resistant tuberculosis (MDR-TB) remains a major public health challenge in China. Hainan, China's largest tropical island, possesses distinct socio-geographical features. However, the drug resistance patterns and molecular epidemiology of MDR-TB in this r…
Lan Y, Li Y, Chen L, Zhang J, Zhang H
… TB in 2017. The objectives of this study were to determine drug resistance profiles of Mycobacterium tuberculosis clinical isolates and to analyze the trends in drug-resistant and multidrug-resistant tuberculosis (MDR-TB) from 2008 to 2015 at a major hospital in Guizhou, a high-…
Mphande-Nyasulu FA, Puengpipattrakul P, Praipruksaphan M, Keeree A, Ruanngean K
…erall, 70.4% of cases were male and 29.6% were female. Mono-drug-resistant TB, multi-drug-resistant TB and extensively-drug-resistant TB were observed in 2.72%, 4.1% and 0.68% of cases, respectively. Although not statistically significant, individuals with comorbidities had a 2.1…
Cai X, Xu X, He G, Jiang X, Wu L
… a global public health concern. This study aims to compare drug resistance in drug-resistant tuberculosis (DR-TB) patients with and without DM and analyse the risk factors of multidrug-resistant tuberculosis (MDR-TB). Methods A total of 893 DR-TB patients were admitted to Wenzho…
Zhao JL, Liu W, Xie WY, Cao XD, Yuan L
…control of TB are greatly difficult, due to the increase in drug-resistant TB, particularly multidrug-resistant TB. We speculated that there were some differences between drug-sensitive and drug-resistant MTB strains and that mazEF 3,6,9 toxin-antitoxin systems (TASs) were involv…
Wencong He, Yun‐Hong Tan, Peiying Li, Jingjing Bao, Yimeng Song, et al.
ObjectiveTo analyze the dynamic trend of drug resistance of Mycobacterium tuberculosis in Leiyang city, Hunan province from 2013 to 2017, and to understand the local drug resistance spectrum of M. tuberculosis, so as to provide evidences for the formulation of chemotherapy regime…
Chiang SS, Brooks MB, Jenkins HE, Rubenstein D, Seddon JA, et al.
Background Household contacts of patients with drug-resistant tuberculosis (TB) are at high risk for being infected with Mycobacterium tuberculosis and for developing TB disease. To guide regimen composition for the empirical treatment of TB infection and disease in these househo…
Cicilia Windiyaningsih, Hendra Badaruddin
…sistant tuberculosis is a global challenge especially multi-drug resistant TB (MDR-TB). Drug-resistant Tuberculosis is classified as a condition where Mycobacterium tuberculosis can’t be treated with anti-tuberculosis drugs. The study aimed to determine the associated risk factor…
Mujuni D, Kasemire DL, Ibanda I, Kabugo J, Nsawotebba A, et al.
Background Second-line drug resistance (SLD) among tuberculosis (TB) patients is a serious emerging challenge towards global control of the disease. We characterized SLD-resistance conferring-mutations among TB patients with rifampicin and/or isoniazid (RIF and/or INH) drug-resis…
Hanif Esmail, Gopalan Narendran, Andrew Nunn
The management of drug-resistant tuberculosis (DR-TB) has been a formidable challenge for patients, healthcare providers and public health systems for many years. In particular, for multidrug-resistant TB (MDR-TB), resistant to both rifampicin and isoniazid, the available treatme…
Microbiologist- External Quality Assurance, State TB control Society, Port Blair, Andaman and Nicobar Islands, Keerthivasan Gurumurthy
… concern in India especially with the increasing numbers of drug-resistant cases of tuberculosis. Lack of early diagnosis, inadequate and inappropriate treatment are the major contributors to the development of drug resistance. PMDT strategy strives for early diagnosis and approp…
Neetha S. Murthy, Sanjeev Nair, P. Ramya, Renu Susan George, B Ravikrishnan, et al.
Resistance to antimycobacterial agents consistently remains a major obstacle to end TB in India. Geographical prevalence data regarding drug-resistant evolutionary genetics of M. tuberculosis (MTB) remains sparse in India. Our objective was to determine the genotypic drug resista…
Hongkuan Yang, Yahong Cheng, Haoli Ma, Y. Li, Bei Han
Objective: To understand the epidemic status of drug-resistant Mycobacteriun tuberculosis in Xi'an in the past three years, and the impact of COVID-19 epidemic during 2020 so as to provide basic information for local multidrug-resistant tuberculosis (MDR-TB) prevention and treatm…
Bhat ZS, Rather MA, Ul Lah H, Hussain A, Maqbool M, et al.
…cidal agents that can shorten treatment duration and target drug resistance still remain a top priority in the discovery of anti-TB drugs. The objective of this study was to investigate the bactericidal potential of 3-cinnamoyl-4-hydroxy-6-methyl-2-pyrone (CHP) against drug-susce…
Ogwang MO, Imbuga M, Ngugi C, Mutharia L, Magoma G, et al.
Introduction Globally anti-tuberculosis drug resistance is one of the major challenges affecting control and prevention of tuberculosis. Kenya is ranked among 30 high burden TB countries globally. However, there is scanty information on second line antituberculosis drug resistanc…
Fizza Mushtaq, Syed Mohsin Raza, Adeel Ahmad, Hina Aslam, Sunia Karam Din, et al.
…nvolves the administration of a panel of five antimicrobial drugs for the period of 6 months. The purpose of this study was to determine antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure and to determine efficacy of the second l…
P Sudha Kumari, M Siva Durga Prasad Nayak, Usha Devi, Susmita Susmita, SG Sushma
…f the World Health Organisation (WHO) on the disease. Multi-Drug Resistant TB (MDR-TB) cases have been increasing in India. About half of the world’s MDR-TB cases are present in India. Aim: To assess the incidence of drug resistant TB in Prakasam district, Andhra Pradesh, India, …
Xiujuan Zhao, Lin Liu, Xingyong Wu, Sijing Li, Biao Liu, et al.
Abstract BackgroundThe emergence of antimicrobial resistance against mycobacterium tuberculosis has become the major concern in global tuberculosis control due to its limited therapy options and high mortality. However, the clinical and molecular characteristics of drug-resistant…
Mevlüt Karataş, Tülin Kuyucu, Tülin Sevim
…btained from TB surveillance forms, bacteriology laboratory drug resistance database and octomed patient follow-up program. Results: N=1146 (65.4%) of the cases were male and n=607 (34.6%) were female. The male/female ratio was 1.8 and the highest cases were observed in the 15-24…
Abebaw Y, Abebe M, Tola HH, Mehammed Z, Getahun M, et al.
…acteriologically confirmed childhood Tuberculosis (PTB) and drug-resistant TB in Ethiopia is limited due to difficulties related to its diagnosis in this population. Therefore, this study aimed to assess bacteriologically confirmed childhood PTB Case Notification Rates (CNRs) and…
Kamolwat P, Nateniyom S, Chaiprasert A, Disratthakit A, Mahasirimongkol S, et al.
Objective To assess the prevalence and risk factors of drug-resistant tuberculosis (TB), the fifth national anti-TB drug resistance survey was conducted in Thailand. Methods A cross-sectional study was conducted by stratified cluster sampling with probability proportional to size…
Che Y, Lin Y, Yang T, Chen T, Sang G, et al.
Setting Controlling drug-resistant tuberculosis in Ningbo, China. Objective Whole-genome sequencing (WGS) has not been employed to comprehensively study Mycobacterium tuberculosis isolates, especially rifampicin-resistant tuberculosis , in Ningbo, China. Here, we aim to character…
Abbas Abel Anzaku
Abstract Background: This study evaluated the prevalence of drug resistant tuberculosis infection among suspected tuberculosis patients attending Asokoro District Hospital (ADH), Abuja, Nigeria. Methods: A total of 301 AFB+/- sputum specimens from suspected TB patients were colle…
Al Mahrouqi S, Gadalla A, Al Azri S, Al-Hamidhi S, Al-Jardani A, et al.
…ulation. The present study examined the genetic profile and drug resistance-conferring mutations in Mycobacterium tuberculosis collected from Omanis and expatriates to recognise possible causes of disease transmission. Methods We examined M. tuberculosis cultured positive samples…
Che Y, Yang T, Lin L, Xiao Y, Jiang F, et al.
Setting: Programmatic management of drug-resistant tuberculosis in Ningbo, China. Objective: To assess whether data-driven genetic determinants of drug resistance patterns could outperform phenotypic drug susceptibility testing in predicting clinical meaningful outcomes among pat…