Showing 1–25 of 200 documents
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Lee JH, Garg T, Lee J, McGrath S, Rosman L, et al.
…icate that the use of World Health Organization recommended diagnostics for TB reduced delays in diagnosing and initiating TB treatment. Future studies evaluating performance and impact of diagnostics should consider reporting time delay estimates based on the standardized report…
Yilin Wang, Zichun Ma, Zubi Liu, Xiaowei Dong, Wei Shu, et al.
…and support broader implementation. Integrating tongue swab diagnostics with existing TB control programs could enhance the detection accuracy, improve drug resistance monitoring and reduce transmissions.
Organisation mondiale de la Santé
Juliana G E Bartels, Nurlan Takenov, Lyailya Chingissova, Anar Rakisheva, Ainur Eleusizova, et al.
**BACKGROUND:** Rapid, accurate detection ofand drug resistance is crucial to reduce tuberculosis (TB) burden and prevent development of drug resistance in high-burden drug-resistant TB regions. **METHODS:** From December 2021 to July 2022, sputum samples from 1214 adult patient…
Zahra Hasan, Sadia Shakoor, Rumina Hasan
…or use [[2]Nicol M.P. Zar H.J. New specimens and laboratory diagnostics for childhood pulmonary TB: progress and prospects.Paediatr Respir Rev. 2011; 12: 16-21Crossref PubMed Scopus (117) Google Scholar,[3]Hasan Z. Shakoor S. Arif F. Mehnaz A. Akber A. Haider M. et al.Evaluation …
Jean de Dieu Iragena, Achilles Katamba, Anandi Martin, Moses Joloba, Willy Ssengooba
…CT Background The implementation of rapid tuberculosis (TB) diagnostics is essential for TB control. Factors influencing their uptake in Africa are unknown. We conducted a survey to collect the status and document Predisposing, Enabling, and Need (PEN) factors influencing so that…
Assebe LF, Erena AK, Fikadu L, Alemu B, Baruda YS, et al.
…ational TB guideline recommends the primary use of rapid TB diagnostics whenever feasible, there is limited evidence available that assess the efficiency of deploying various diagnostic tools in the country. Hence, this study aims to evaluate the cost-effectiveness of rapid TB/MD…
Christoph Lange, Professor
This study aims at identifying and evaluating novel diagnostic methods for children evaluated for respiratory tuberculosis. The investigators will use alternative samples like stool, urine, and masks to diagnose children with respiratory tuberculosis. Once diagnosed, the investig…
Andama A, Somoskovi A, Mandel B, Bell D, Gutierrez C
…ug resistant TB. The ultimate goal is to improve laboratory diagnostics and better individualized managementof detected TB, and make an important contribution toward eliminating this global epidemic. RATIONALE: Tuberculosis persists as one of the world's most deadly infectious di…
World Health Organization
This operational handbook provides practical guidance for the implementation of WHO policies and recommendations on rapid diagnostic technologies for tuberculosis (TB) and drug-resistant tuberculosis (DR-TB). The publication describes WHO-recommended diagnostic tests and testing …
І. В. Ліскіна, С. Д. Кузовкова, Л. М. Загаба, О.D. Nikolaeva
… diagnosed in 13 % of cases. The main methods of laboratory diagnostics were classical bacteriological methods — simple direct light microscopy and MBT culture, the positive results of which were obtained in only half of all studies, as well as molecular-genotypic tests. Prevalen…
Ng KC, Meehan CJ, Torrea G, Goeminne L, Diels M, et al.
…s have adopted connectivity solutions that allow linking of diagnostics, real-time capture, and shared repository of these test results. However, these connected diagnostics and readily available test results are not used to their full capacity, as we have yet to capitalize on fu…
Lin D, Wang X, Li Y, Wang W, Li Y, et al.
The prevalence of drug-resistant Mycobacterium tuberculosis (Mtb) strains makes disease control more complicated, which is the main cause of death in tuberculosis (TB) patients. Early detection and timely standard treatment are the key to current prevention and control of drug-re…
Modlin SJ, Mansjö M, Werngren J, Ejike CM, Hoffner SE, et al.
…TB) reported as PZA-susceptible (PZA-S) by common molecular diagnostics. Phenotypic susceptibility testing (pDST) indicated PZA-R TB. Targeted Sanger sequencing reported wild-type PncA, indicating PZA-S TB. Whole Genome Sequencing (WGS) by PacBio and IonTorrent both detected dele…
Kassa GM, Merid MW, Muluneh AG, Wolde HF
Background To end Tuberculosis (TB) by 2030, early detection and timely treatment of Drug-Resistant Tuberculosis (DR-TB) is vital. The role of rapid, accurate, and sensitive DR-TB diagnostic tool is indispensable to accelerate the TB control program. There are evidence breaks in …
Muniyandi M, Lavanya J, Karikalan N, Saravanan B, Senthil S, et al.
Background The National Tuberculosis Elimination Programme (NTEP) of India is aiming to eliminate TB by 2025. The programme has increased its services and resources to strengthen the accurate and early detection of TB. It is important to estimate the cost of TB diagnosis in India…
World Health Organization
This operational handbook provides practical guidance for implementing WHO policies and recommendations on rapid diagnostic technologies for tuberculosis (TB) and drug-resistant tuberculosis (DR-TB). The publication describes WHO-recommended diagnostic tests for the detection of …
Anura David, Lyndel Singh, Manuel Pedro da Silva, Keneilwe Peloakgosi-Shikwambani, Zanele Nsingwane, et al.
Abstract Background Despite advances in molecular diagnostics, only 48% of newly diagnosed tuberculosis (TB) cases were confirmed using nucleic acid amplification tests (NAATs) in 2023. The BD MAX TM MDR-TB (MAX MDR-TB) assay, a moderate complexity NAAT, detects Mycobacterium tub…
Ankur Kumar, Amresh Kumar Singh, Vivek Gaur, Ashwini Kumar Mishra, Anita Mehta, et al.
…prevalence (4.13%) underscores the need for rapid molecular diagnostics to guide treatment. However, global EPTB burden estimates remain inconsistent, necessitating standardized surveillance and diagnostic protocols to improve detection accuracy and inform public health strategie…
World Health Organization
…ted guidelines on tuberculosis, Module 3: diagnosis – rapid diagnostics for tuberculosis detection. The publication presents evidence-to-decision tables developed to support WHO recommendations on the use of rapid diagnostic technologies for tuberculosis and drug-resistant tuberc…
Siavash Valafar
…revalence and co-occurrence, and their utility in molecular diagnostics. The genes commonly associated with INH resistance, katG, inhA, fabG1 , and the intergenic region oxyR’ - ahpC were considered in this review. In total, 52 articles were included describing 5,632 INH R clinic…
Anuj Pathak, Reena Raveendran, Jaswinder Kaur Oberoi, Chand Wattal, Anil Arora, et al.
**BACKGROUND:** Abdominal tuberculosis (TB) poses diagnostic difficulties due to its vague symptoms and low bacterial load. Culture, the gold standard, is limited by a prolonged turnaround time of up to eight weeks. Xpert MTB/RIF Ultra (Xpert Ultra), a rapid, automated molecular …
Zhen Feng, Shijia Ge, Peiwen Miao, Mei Liu, Qing Li, et al.
**UNLABELLED:** Effective tuberculosis (TB) management relies on prompt diagnosis ofcomplex (MTBC) and associated drug resistance. The Sanity 2.0 assay is a high-resolution melting assay designed for direct respiratory sample testing, enabling simultaneous detection of MTBC and r…
Anura David, Lyndel Singh, Manuel Pedro da Silva, Keneilwe Peloakgosi-Shikwambani, Zanele Nsingwane, et al.
**UNLABELLED:** Despite the availability of molecular diagnostics, only 48% of newly diagnosed tuberculosis (TB) cases were confirmed using nucleic acid amplification tests in 2023. The MAX Multi Drug Resistant Tuberculosis (MAX MDR-TB) assay detectscomplex (MTBC) and resistance …
Md Mahbub Ullah, Haris Riaz Khan, Aroosha Imran, Noman Ahmed, Kifayat Ullah, et al.
…view aimed to critically evaluate recent advancements in TB diagnostics, focusing on the integration of mass spectrometry, artificial intelligence, and genomics in comparison to conventional and molecular methods, and to assess their clinical applicability and limitations. Method…