WHO operational guidelines on tuberculosis: module 3: diagnosis: rapid diagnostics for tuberculosis detection: web annex C: evidence-to-decision tables

This web annex accompanies the third edition of the WHO consolidated guidelines on tuberculosis, Module 3: diagnosis – rapid diagnostics for tuberculosis detection. The publication presents evidence-to-decision tables developed to support WHO recommendations on the use of rapid diagnostic technologies for tuberculosis and drug-resistant tuberculosis. It summarizes the assessment processes used by guideline development groups, including considerations related to diagnostic accuracy, desirable and undesirable effects, certainty of evidence, resource requirements, cost–effectiveness, feasibility, acceptability and equity.

The document covers multiple diagnostic platforms and approaches, including Xpert MTB/RIF and Xpert Ultra assays, Truenat tests, loop-mediated isothermal amplification, lateral flow urine lipoarabinomannan assays, line probe assays and targeted next-generation sequencing. Evidence is presented for different populations and clinical settings, including adults, children and people living with HIV. The annex also outlines implementation considerations, subgroup analyses and research priorities associated with the use of these technologies. Its purpose is to provide transparency regarding the evidence appraisal and recommendation development processes underpinning WHO guidance on rapid diagnostics for tuberculosis detection and drug-resistance testing.