Showing 1–25 of 30 documents
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du Preez K, Osman M, Seddon JA, Naidoo P, Schaaf HS, et al.
Background Few studies have evaluated tuberculosis control in children and adolescents. We used routine tuberculosis surveillance data to quantify age- and human immunodeficiency virus (HIV)-stratified trends over time and investigate the relationship between tuberculosis, HIV, a…
A.A. Danhausa, E.E. Daniel, C.J. Shawulu, Adamu Nuhu, L. Philemon
Regardless of many decades of research, the widespread availability of a vaccine and more recently highly visible WHO efforts to promote a unified global control strategy, Tuberculosis remains a leading cause of infectious mortality. In this paper, a Mathematical Model for Tuberc…
Conor J. Meehan
… genomic data either alone or in conjunction with classical epidemiology to investigate TB transmission dynamics in the Canadian North, (Tyler et al., 2017; Lee et al., 2015a; Lee et al., 2015b) with the aim of identifying clusters to help guide public health interventions. Thus …
Robyn S. Lee, Jean‐François Proulx, Fiona McIntosh, Marcel A. Behr, William P. Hanage
… genomic data either alone or in conjunction with classical epidemiology to investigate TB transmission dynamics in the Canadian North, (Tyler et al., 2017; Lee et al., 2015a; Lee et al., 2015b) with the aim of identifying clusters to help guide public health interventions. Thus …
Katherine C Horton, Alvaro Schwalb, Martin J Harker, Lara Goscé, Elena Venero-Garcia, et al.
… or evaluated between settings with different background TB epidemiology and structural drivers. **METHODS:** We calibrated a deterministic TB model to epidemiological indicators in Brazil, India, and South Africa. We implemented seven interventions across countries focusing on …
van den Boom M, Bennani K, Sismanidis C, Gunneberg C, Khawaja L, et al.
Background In Pakistan, 84% of healthcare is provided by the private sector. We conducted an epidemiological and programme review for TB to document progress and guide further efforts. Methods Surveillance and data systems were assessed before analysing epidemiological data. We r…
Y L Lew, M M D Goroh, S T Yerkovich, A M H Seow, G S Rajahram, et al.
…hose with drug-sensitive TB (DS-TB). Our study examined the epidemiology of DR-TB in Sabah, Malaysia, a state with high TB burden. We aimed to identify factors associated with poor treatment outcomes. **STUDY DESIGN:** Retrospective cohort study. **METHODS:** Data were derived …
Ruizhuang Sun, Yan Jiang, Yingyu Yan, Tingxia Zhou, Chonghui Xu, et al.
**BACKGROUND:** With the widespread implementation of antiretroviral therapy (ART), human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) has gradually transitioned from a highly fatal infectious disease to a manageable chronic condition. Simultaneously, glob…
Benito P, Vashakidze S, Gogishvili S, Nikolaishvili K, Despuig A, et al.
This study aimed to determine the health-related quality of life (HRQoL) of patients with pulmonary tuberculosis (TB) and to assess its change after a therapeutic surgical procedure. In this scenario, the purpose was to elucidate and quantify the effect of various demographic, ep…
Jeong D, Kim J, Lee SW, Choi H, Sohn H, et al.
… comprehensive, linked dataset for advancing research on TB epidemiology, treatment outcomes, comorbidities, and health disparities. It enables evaluations of public health interventions, long-term prognosis, and strategies for post-TB care. This cohort will remain a valuable res…
Susanna S van Wyk, Marriott Nliwasa, F. Lu, Chih-Chan Lan, James A. Seddon, et al.
<sec> <title>BACKGROUND</title> Finding individuals with drug-resistant tuberculosis (DR-TB) is important to control the pandemic and improve patient clinical outcomes. To our knowledge, systematic reviews assessing the effectiveness, cost-effectiveness, acceptability, and feasib…
Ahmad Fuady
Estimating tuberculosis incidence, prevalence, and deaths are crucial to capture the tuberculosis burden and to assess the progress towards tuberculosis elimination in 2035. WHO publishes a report of estimated tuberculosis burden each year, showing that tuberculosis remains among…
Karen D. Serrano, Scott A. Fruhan
…ssociated with TB. This review details the pathophysiology, epidemiology, clinical presentation, and treatment of pulmonary infection, including pneumonia, empyema, pulmonary abscess, and tuberculosis (TB). Figures show chest radiographs of reactivation pulmonary tuberculosis, HI…
Karen D. Serrano, Scott A. Fruhan
…ssociated with TB. This review details the pathophysiology, epidemiology, clinical presentation, and treatment of pulmonary infection, including pneumonia, empyema, pulmonary abscess, and tuberculosis (TB). Figures show chest radiographs of reactivation pulmonary tuberculosis, HI…
Dillon Prus, Robert Lenox
Moxifloxacin (MXF) is a cornerstone of the newly recommended four-month 2HPMZ/2HPM regimen for drug-susceptible pulmonary tuberculosis (TB). However, potential side effects such as cumulative neurotoxicity remain poorly characterized in clinical practice. Here, we report a rare c…
Bea S, Lee H, Kim JH, Jang SH, Son H, et al.
Background: Adherence to tuberculosis (TB) drugs is one of the key aspects of global TB control, yet there is a lack of epidemiological evidence on the factors influencing adherence to TB drugs. Thus, this study aimed to explore the adherence and factors associated with adherence…
Chidambaram V, Ruelas Castillo J, Kumar A, Wei J, Wang S, et al.
Tuberculosis (TB) and atherosclerotic cardiovascular disease (ASCVD) have a close epidemiological and pathogenetic overlap. Thus, it becomes essential to understand the relationship between ASCVD and TB outcomes. From our retrospective cohort on drug-susceptible TB patients at th…
Radtke KK, Dooley KE, Dodd PJ, Garcia-Prats AJ, McKenna L, et al.
Background Malnourished and young children are particularly susceptible to severe forms of tuberculosis and poor treatment response. WHO dosing guidelines for drugs for tuberculosis treatment are based only on weight, which might lead to systematic underdosing and poor outcomes i…
Arinaminpathy N, Gomez GB, Sachdeva KS, Rao R, Parmar M, et al.
There is increasing interest in future, highly-potent 'pan-TB' regimens against tuberculosis (TB), that may be equally effective in both drug-susceptible and rifampicin-resistant (RR) forms of TB. Taking the example of India, the country with the world's largest burden of TB, we …
McDonald AK, Nakkonde D, Kaggwa P, Zalwango S, Joseph A, et al.
Background Growing evidence suggests that post-TB-related morbidity occurs often among TB survivors, but there is limited epidemiological data on the burden of symptoms and disability after successful completion of treatment. We evaluated the prevalence of TB-related symptoms, se…
Debdeep Mitra, P. Sanyal, Divya Kamboj, Rakesh Kumar Deepak, Sayan Chakraborty, et al.
…erapy in DR-TB treatment may have significant impact on the epidemiology of disease transmission.
V.B. Avdentova, E.M. Belilovsky, Borisov Se, E. M. Bogorodskaya, O. N. Zuban, et al.
Objective: to determine the association of various patient characteristics with unfavourable treatment outcomes of adult pulmonary tuberculosis (TB) without multidrug resistance in a region with low epidemiological rates. Methods. We studied treatment outcomes in 887 drug-suscept…
Liu Y, Moodley M, Pasipanodya JG, Gumbo T
Antimicrobial susceptibility testing, based on clinical breakpoints that incorporate pharmacokinetics/pharmacodynamics (PK/PD) and clinical outcomes, is becoming a new standard in guiding individual patient therapy as well as for drug resistance surveillance. However, for most an…
Benjamin Idoko Omede, Olumuyiwa James Peter, William Atokolo, Bolarinwa Bolaji, Tawakalt Abosede Ayoola
The rise of drug resistance has become a major obstacle in treating tuberculosis (TB), significantly contributing to the increasing disease burden. Therefore, it is essential to study the transmission dynamics of the disease, considering the factors that contribute to the strain’…
Seung Won Lee, Doosoo Jeon, Hongjo Choi, Chiwook Chung, Jeongha Mok, et al.
…s study investigated the effect of population ageing on the epidemiology of tuberculosis (TB) in South Korea. **METHODS:** We conducted a retrospective cohort study using an integrated database from three national databases. We analysed trends in age-specific TB incidence, morta…