Showing 1–25 of 200 documents
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Urooj Ahmad, Anab Arshad, Sara Jadoon, Shahana Saba Salih, Hafsa Ahmed, et al.
…research was to find out the demographic characteristics of drug-susceptible and drug-resistant Tuberculosis in Khyber Pakhtunkhwa, Pakistan. Material and Methods: A retrospective survey was conducted on data from the TB Control Program Khyber Pakhtunkhwa recorded between 1st Jan…
Susanna S van Wyk, Marriott Nliwasa, James A. Seddon, Graeme Hoddinott, Lario Viljoen, et al.
ABSTRACT Background Transmission of drug-resistant tuberculosis (TB) is ongoing, and many households face catastrophic costs when a member is diagnosed and treated for drug-resistant TB. Finding individuals with drug-resistant TB and initiating treatment as early as possible is i…
Satyendra N. Shukla, Nitin Bhardwaj, Ashutosh Singh
…has emerged as a health risk due to its ability to adapt to drugs . The emergence of drug-resistant Mtb is affected by factors such as drug-resistant gene mutations, the efficacy of TB treatment, genetic background of the strain, and its ability to adapt to host and specific envi…
E. E. Lesnik, S. Ginda
…e main parameters of cellular, humoral immunity and natural resistance in tuberculosis patients with primary and acquired multiple drug resistance; to study the correlation of these parameters with clinical and radiological manifestations. Subjects and Methods. A prospective stud…
Yiwang Chen, Howard Takiff, Qian Gao
…g (WGS) has shown great potential in the rapid diagnosis of drug-resistant tuberculosis;1Finci I Albertini A Merker M et al.Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multice…
Hasan Ismail Sultan, Ibrahim Khalil Ibrahim
…uberculosis (TB) is an international public health problem. Drug resistant tuberculosis is a considerable global health risk, leading the ongoing TB epidemic and increasing the morbidity and mortality of TB worldwide. Incomplete and insufficient therapeutic regimens can result in…
Nduagu Samuel Uchechukwu, ONYEAGWARA Ngozi Carol, Ogisi Festus Oritsemajemite, MBATA Godwin Chukwuemeka
…challenge facing the global efforts against tuberculosis is drug-resistance, which necessitates the use of aminoglycoside-based second line drugs that are known to have ototoxic potentials. Hearing impairment can be a source of social distress, professional disability and in some…
Naveen Pandhi, Ritu Dadra, Balbir Malhotra, Dr. P Prasanth
…ases were in the age group of 21-30 years, 147 (73.5%) were drug susceptible (DS) and 53 (26.5%) were drug resistant (DR). Amongst DR-TB cases, 21 (18.7%) were new and 32 (36.4%) were previously treated cases. Rifampicin mono-resistance was higher in both new (47.6%) and previous…
Bui VCB, Yaniv Z, Harris M, Yang F, Kantipudi K, et al.
Tuberculosis (TB) drug resistance is a worldwide public health problem. It decreases the likelihood of a positive outcome for the individual patient and increases the likelihood of disease spread. Therefore, early detection of TB drug resistance is crucial for improving outcomes …
Ankita Pal, Sapna Pal, Shweta Mahapatra, Apratim Pandey, Debasisa Mohanty
…d on the statistical significance of their association with resistance or susceptibility to various drugs. However, the mechanism by which they confer resistance to drugs is often not understood. To address these gaps, we combined known resistance associated mutations from the WH…
Nathan Hicks
…acy of this therapy has been undermined by the evolution of drug resistant Mtb strains, which are able to grow in the presence of clinically utilized antibiotics. The chromosomal mutations that cause drug resistance in Mtb have largely been identified, allowing for rapid genotype…
Josephine Amie Koroma, Mariama Mahmoud, Bailah Molleh, Stephen Sevalie, Adrienne K. Chan, et al.
…eone are missing each year. Challenges with notification of drug-susceptible TB can result in drug-resistant TB. The COVID-19 pandemic has further compounded these challenges, resulting in increased drug-resistant TB cases and poor treatment outcomes. This study highlights the ef…
Usharani Brammachary, Venkateswari Ramachandra, Suganthi Palavesam, Vidya Raj Cuppusamy Kapalamurthy, Aaina Muralidhar, et al.
…ry TB regimens consist of 6–9 months of daily doses of four drugs in the existing regimen that is extremely toxic to patients. The purpose of these longer treatments is to eliminate Mycobacterium tuberculosis, notorious for its ability to resist most antimycobacterial drugs, ther…
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
…etic diversity and lineage-specific association of Mtb with drug resistance among pulmonary tuberculosis patients.</p><p>Methods: Sputum samples were collected from pulmonary tuberculosis patients at six different healthcare institutions in Tigray, Ethiopia, between J…
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
…etic diversity and lineage-specific association of Mtb with drug resistance among pulmonary tuberculosis patients.</p><p>Methods: Sputum samples were collected from pulmonary tuberculosis patients at six different healthcare institutions in Tigray, Ethiopia, between J…
Jees Sebastian, Anooja Thomas, Carly Levine, Riju Shrestha, Shawn Levy, et al.
…atment are poor predictors of final therapeutic outcomes in drug-susceptible disease suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting Mycobacterium tuberculosis (Mtb) population. We developed a multi-transwell …
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
…etic diversity and lineage-specific association of Mtb with drug resistance among pulmonary tuberculosis patients.</p><p>Methods: Sputum samples were collected from pulmonary tuberculosis patients at six different healthcare institutions in Tigray, Ethiopia, between J…
Sebastian J, Thomas A, Levine C, Shrestha R, Levy S, et al.
…atment are poor predictors of final therapeutic outcomes in drug-susceptible disease, suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting Mycobacterium tuberculosis population. We developed a multitranswell roboti…
Qian Zhai, Xianglong Kong, Qian Li, Na Yang
…tinase-3-like protein 1 (YKL-40) levels are associated with drug-resistant Mycobacterium tuberculosis in children with pulmonary tuberculosis. **METHODS:** In this prospective observational study, 235 pediatric pulmonary tuberculosis patients treated at Hebei Provincial Chest Ho…
Welekidan LN, Yimer SA, Skjerve E, Dejene TA, Homberset H, et al.
…etic diversity and lineage-specific association of Mtb with drug resistance among pulmonary tuberculosis patients. Methods: Sputum samples were collected from pulmonary tuberculosis patients at six different healthcare institutions in Tigray, Ethiopia, between July 2018 and Augus…
Yang F, Yu H, Kantipudi K, Karki M, Kassim YM, et al.
Background Tuberculosis (TB) drug resistance is a worldwide public health problem that threatens progress made in TB care and control. Early detection of drug resistance is important for disease control, with discrimination between drug-resistant TB (DR-TB) and drug-sensitive TB …
Allué-Guardia A, García JI, Torrelles JB
… (MDR), extensively (XDR), extremely (XXDR) and total (TDR) drug-resistant Mycobacterium tuberculosis ( M.tb ) strains have emerged as a threat to public health worldwide, stressing the need to develop new tuberculosis (TB) prevention and treatment strategies. It is estimated tha…
Shurygina AS, Zabolotnykh NV, Vinogradova TI, Vitovskaya ML, Dogonadze MZ, et al.
The steady rise of drug-resistant tuberculosis (TB), which renders standard therapy regimens ineffective, necessitates the development of innovative treatment approaches. Immunotherapeutic vaccines have the potential to effectively regulate the anti-TB immune response and enhance…
O. Omosebi, Olanrewaju S.O., Adejumo O.A.
…the country. Hence, this paper aims to model the outcome of drug-resistant-tuberculosis and drug-susceptible-tuberculosis patients in Oyo state of Nigeria using the logit function of estimating binary logistic regression model vis-à-vis identifying the success of these TB treatme…
Soedarsono Soedarsono, Alvian Fauzi, Anita Widyoningroem, Ni Made Mertaniasih
Background: Drug-resistant (DR) pulmonary tuberculosis (TB) is often associated with morbidity and mortality compared to drug-susceptible (DS) pulmonary TB. The infectiveness and pathological destruction of DR TB and DS TB strains are still controversial. Objectives: This study a…