Showing 176–200 of 200 documents
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Suárez I, Gruell H, Heyckendorf J, Fünger S, Lichtenstein T, et al.
Introduction Central nervous system (CNS) tuberculomas are a challenging manifestation of extrapulmonary tuberculosis often leading to neurological complications and post-treatment sequelae. The role of adjunctive corticosteroid treatment is not fully understood. Most guidelines …
Feroz W, Sheikh AMA, Mugada V
Tubercular mastitis is a rare form of extrapulmonary tuberculosis commonly seen in multiparous and lactating women in developing countries. It is a diagnostic challenge and commonly misdiagnosed as breast carcinoma. Tubercular mastitis is paucibacillary, and fine-needle aspiratio…
Abdelgawad N, Wasserman S, Abdelwahab MT, Davis A, Stek C, et al.
Background Linezolid is evaluated in novel treatment regimens for tuberculous meningitis (TBM). Linezolid pharmacokinetics have not been characterized in this population, particularly in cerebrospinal fluid (CSF), as well as, following its co-administration with high-dose rifampi…
Ge H, Liang X, Lu Q, He A, Zhong P, et al.
Background The taxonomic group of non-tuberculous mycobacteria (NTM) encompasses more than 190 species and subspecies, some of which can cause pulmonary and extrapulmonary diseases across various age groups in humans. However, different subspecies exhibit differential drug sensit…
Lanzafame M, Vento S
…to silica dust. Chemoprophylaxis is possible with different regimens and needs to be expanded around the world, but efficacy is unfortunately limited. Silico-tuberculosis is still a challenging health problem in many countries and deserves attention worldwide.
Areas Lisboa Netto T, Diniz BD, Odutola P, Dantas CR, de Freitas MCFLC, et al.
…ulosis (TB) treatment demands strict adherence to multidrug regimens. Directly Observed Therapy (DOT) poses challenges, especially regarding adherence. With the popularization of smartphones, Video-Observed Therapy (VOT) has emerged as a promising alternative, allowing healthcare…
Le X, Shen Y
…e the current progress in the timing of ART initiation, ART regimens, drug-drug interactions between anti-tuberculosis and antiretroviral agents, and IRIS.
Moodley S, Dlwati MS, Bhigjee AI
…lly in developing countries such as South Africa. Treatment regimens have been extrapolated from treatment for pulmonary tuberculosis, and the intensive-phase duration of 2 months may be inadequate for treatment of patients with TBM. We highlight this situation with a case report…
Jian Y, Bao Y, Yang F, Zhu M
Background Tuberculous meningitis (TBM) is a non-purulent inflammatory condition affecting the meninges and spinal membranes, caused by Mycobacterium tuberculosis (MTB) infection. This study seeks to explore the impact of varying INH dosages and NAT2 gene polymorphisms on TBM tre…
Djochie RDA, Anto BP, Opare-Addo MNA
Background The success of tuberculosis treatment relies on patients adhering to their medication regimen consistently. However, adherence levels tend to decrease among patients who experience adverse drug reactions to antitubercular medications, leading to suboptimal treatment ou…
Yadav S
Female genital tract tuberculosis (TB) is less frequently reported, even in endemic countries. Often, the diagnosis is incidental and is seen with the involvement of pulmonary or extrapulmonary sites. Isolated female genital tract TB is quite rare, and cases of primary extrapulmo…
Bausch K, Mantica G, Smith EJ, Bartoletti R, Bruyère F, et al.
Although tuberculosis (TB) ranks among the most frequent infectious diseases worldwide, one of its extrapulmonary (EP) manifestations, genitourinary (GU) TB, is often underestimated by urologists, particularly in areas such as Europe where TB is not endemic. The aim of this revie…
Lee IH, Kim SG, Kwon JG, Yang CS, Kang S, et al.
Rationale Intestinal tuberculosis (TB) is rarely seen in patients with end-stage renal disease (ESRD). We report an intestinal TB case with a clinical presentation similar to that of colon cancer in a patient with ESRD on hemodialysis. Patient concerns A 49-year-old man presented…
Ramanath Mahale, Diksha Shirodkar, Jumail Khader, H. K. Mithun, Amanullah M. Bappanad
Childhood tuberculosis (TB) remains a major global health issue, particularly in high-burden countries like India, which accounts for 26% of global TB cases. The national TB elimination programme has adopted a focused approach to meet the World Health Organization (WHO’s) end TB …
R C Kerr, L Samuels, T Foster, T Baker
Abstract Introduction Spinal Tuberculosis (TB) is a form of extrapulmonary TB. Delayed diagnosis can lead to abscess formation, spinal destruction and neurologic impairment. Case Presentation A 36-year-old male with no known chronic illness presented with a one-year history of pr…
Anna Eugênia Villela Martins Naves, Natália Sousa Costa, Moara Alves Santa Bárbara Borges, Adriana Oliveira Guilarde, Vanessa Lara Guimarães
Tuberculosis (TB) is a preventable and curable infectious disease caused by Mycobacterium tuberculosis. More than 10 million people continue to develop TB every year, a number that has been rising since 2021. Although TB mainly affects the lungs, extrapulmonary forms occur in 10–…
Gisele Oro Boff, Betina Giordani, Aline Bertarello, Matheus Gonçalves de Oliveira, Mateus Swarovsky Helfer, et al.
Cutaneous Tuberculosis (CT), a rare and difficult-to-diagnose form, represents less than 2% of extrapulmonary cases and has varied clinical manifestations. The sporotrichosis-like form, with nodules along the lymphatic pathway, mimics other dermatoses. Therefore, we report a case…
Natali D, Cloatre G, Brosset C, Verdalle P, Fauvy A, et al.
…es clinical features of EPT, diagnostic tests and treatment regimens.
Abdelmahmuod EA, Elayana M, Subahi E, Aker L, Alamin MA, et al.
Introduction TLA is most commonly associated with an immunocompromised state, a focus of infection in the lungs or gastrointestinal system, or as part of congenital or miliary tuberculosis. Isolated TLA is rare, with only a few cases reported in the literature. Methods We describ…
Haddad F, Afifi M, El Rhaoussi FZ, Tahiri M, Hliwa W, et al.
According to the World Health Organization (WHO), tuberculosis (TB) is the 13th cause of death worldwide and the second infectious killer after HIV. It is an endemic disease in Morocco. Isolated appendicular TB is an uncommon form of extrapulmonary TB. We report a case of a 26-ye…
Yudintceva N, Bobkov D, Sulatsky M, Mikhailova N, Oganesyan E, et al.
…n, particularly with a decrease in efficacy of conventional regimens. In the present study, we investigated the therapeutic potency of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in the complex anti-tuberculosis treatment (ATT). A rabbit model of renal tubercul…
Anil Kumar, Gopalsing Rajput, Ann Maria Paulose, Siddharth Bhatt, Veena Kharayat
Extrapulmonary tuberculosis (EPTB) makes up 20%–30% of all tuberculosis cases, with genitourinary involvement representing 28%–30% of EPTB presentations. Cutaneous tuberculosis accounts for about 2% of EPTB cases [1]. Primary penile tuberculosis, isolated to the glans penis, is e…
Takakazu Ribas Asato I, Souza Novaes Asato N, Amariz Yamamoto F, Ferreira Siqueira AC, Pereira da Silva AM
This case is relevant for describing a rare presentation of intestinal tuberculosis with perianal manifestations, complicated by abscesses and recurrent fistulas. The clinical manifestations mimicked Crohn's disease and other inflammatory conditions, making the diagnosis challeng…
Geovani Santos da Silva, Isabela Sacco Camara, Helena Soares Feijoó, Danilo Luiz Marques de Carvalho, Giovana Reis de Abreu Ribeiro
Tuberculosis (TB) is one of the main causes of global morbidity and mortality, with high incidence in immunosuppressed patients, especially people living with HIV (PLHIV). Extrapulmonary forms, such as tuberculous osteomastoiditis (OT), are rare and difficult to diagnose, given t…
Thee S, Basu Roy R, Blázquez-Gamero D, Falcón-Neyra L, Neth O, et al.
Background Currently, data on treatment, outcome, and prognostic factors in children with tuberculous meningitis (TBM) in Europe are limited. To date, most existing data on TBM originate from adult studies, or studies conducted in low-resource settings. Methods We designed a mult…