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Ngadaya E, Kimaro G, Sandi E, Mnyambwa NP, Wilfred A, et al.
Background Diagnosis of pulmonary tuberculosis remains grim, especially in resource-limited settings. Low quality of sputum, particularly among seriously ill, HIV/AIDS, and pediatric patients might result in missing the diagnosis. This study evaluated the performance of GeneXpert…
Meredith B Brooks, Giordano Sosa Soto, Jeffrey I Campbell, Farhana Amanullah, Tapash Roy, et al.
Pediatric extrapulmonary tuberculosis (EPTB) remains under-recognized due to biological, diagnostic, and systemic barriers. This Perspective outlines pragmatic, multilevel strategies-spanning frontline clinics to national systems-to strengthen diagnosis, reporting, and visibility…
Movahedi Z, Mahmoudi S, Banar M, Pourakbari B, Aziz-Ahari A, et al.
Introduction Reductions in global tuberculosis incidence are considered as one of the End TB Strategy goal. The diagnosis of tuberculosis (TB) in children is challenging due to insufficient specimen material and the scarcity of bacilli in specimens. The purpose of this study was …
Nicol MP, Wood RC, Workman L, Prins M, Whitman C, et al.
Microbiological diagnosis of pediatric pulmonary tuberculosis (TB) is challenging due to the difficulty of collecting and testing sputum from children. We investigated whether easily-obtained oral swab samples are useful alternatives or supplements to sputum. Oral swabs and induc…
Daniel Edisha Garba, Uju Marie-Esther Dibua, Chiamaka Ukamaka Oka, Yvonne Ogechukwu Ozoadibe, Friday Attah, et al.
Urogenital tuberculosis (UGTB) is a common extrapulmonary manifestation of TB, but its diagnosis remains challenging due to nonspecific symptoms and limited diagnostic tools. Despite its significant impact on global health, it remains incompletely understood and often overlooked.…
Cai Q, Shen X, Li H, Yao C, Sun N, et al.
Background Mycobacterium tuberculosis (Mtb)-specific perforin were significantly increased in patients with tuberculosis. This study aims to evaluate the diagnosis value of Mtb-specific perforin in pediatric patients with tuberculosis. Methods Diagnostic performance of perforin l…
Khondker Qamruzzaman, Syed Ahsan Tauhid, Dr. Md. Ashiqur Rahman, Sk Sadek Ali, Dr. Md. Nahidul Islam, et al.
Background: Pulmonary tuberculosis (PTB) remains a significant health issue in children. Early and accurate diagnosis is critical but challenging, The GeneXpert test, a rapid and accurate molecular diagnostic tool, has improved TB detection by identifying Mycobacterium tuberculos…
Made Winatra Satya Putra, Made Agus Maharjana, I Ketut Siki Kawiyana
Background: Tuberculosis of the bone is a serious problem in developing countries, extra-pulmonary tuberculosis is more common among children. The characteristics of tuberculosis osteomyelitis in children are different. Therefore, the disease is often neglected or diagnosis is de…
Meyer Children's Hospital IRCCS
…s were reported in 2020, of which 1 million occurred in the pediatric population. However, epidemiological data available on tuberculosis (TB) in pediatric age are extremely limited due to diagnostic challenges in this patient category. Furthermore, children are almost never incl…
Claudia Ozela El- Husny, Ângela Maria Rodrigues Ferreira, Jamilie Suelen dos Prazeres Campos, Kamila Nancy Gonçalves da Gama, Iací Proença Palmeira, et al.
Introduction: Tuberculosis control tools are a challenge to primary health care, due to the delay of people from the appearance of the first symptoms to the search for the first health-care service, and health-care services leading to difficulties and delay in establishing the di…
Geweniger A, Janda A, Eder K, Fressle R, Kannan CV, et al.
Background The microbiological diagnosis of pulmonary tuberculosis (Tb) in a pediatric population is hampered by both low pathogen burden and noncompliance with sputum sampling. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been found u…
Deepmala Pandey, Ankur Yadav
Background: Body fluids are commonly used for diagnosis as sputum is not reliable in children. Hence it is essential to study efficacy of body fluids in comparison to GeneXpert which is a new diagnostic modality. Objectives of this study was to incidence of rifampicin resistance,…
Muhammad Ali Shodikin, Desie Dwi Wisudanti, Annisa Nadhifa Witanto
Background: Tuberculosis (TB) remains a major public health problem globally. TB in children is an important component in TB control. The diagnosis of TB in children until now is still challenging, underdiagnosis often occurs in primary health facilities in Indonesia. This study …
E. P. Еremenko, Е. А. Бородулина, I. A. Sergeeva, D.А. Kudlаy, B. E. Borodulin
…ests (Mantoux test with 2 TU PPD-L and diaskintest) for the diagnosis of tuberculosis infection, in vitro tests are used. One of these tests is T-SPOT.TB being more widely used in recent years. The objective : to evaluate the effectiveness of T-SPOT.TB test for early detection of…
Singhal R, Dayal R, Bhatnagar S, Nayak M, Yadav N, et al.
…d as compared to CBNAAT in gastric aspirate (GA) samples in pediatric tuberculosis (TB). Methods This cross-sectional study was performed at Department of Pediatrics of a tertiary care hospital. Children aged 0-18 y diagnosed as presumptive tuberculosis were consecutively enrolle…
Anastasia Y. Starshinova, И. Ф. Довгалюк, Ulia Ovchinnikova, Анна Старшинова, P. K. Yаblonskiy
<b>Introduction:</b> Early diagnosis of TB infection in children is complicated due to poor clinical signs, minor X-ray abnormalities, and absence of bacterial excression. Potential of Mantuox 2 TE test in population with common BCG vaccination is limited due to its low diagnosti…
Xiaoxia Wang, Shaomei Huang, Hua Chen
… clinical and Imaging characteristics between children with pediatric pulmonary tuberculosis (PTB) and children with pneumonia who were initially suspected of PTB, and to explore valuable indicators for differential diagnosis. Methods This retrospective study enrolled pediatric i…
Farina E, D'Amore C, Lancella L, Boccuzzi E, Ciofi Degli Atti ML, et al.
Background Intercepting earlier suspected TB (Tuberculosis) cases clinically is necessary to reduce TB incidence, so we described signs and symptoms of retrospective cases of pulmonary TB and tried to evaluate which could be early warning signs. Methods We conducted a retrospecti…
Ana Alvarez, Mobeen H. Rathore
…ies have led to several new recommendations in the areas of diagnosis and treatment of pediatric tuberculosis in the past few years. Due to the low incidence of tuberculosis in the United States, many primary care providers may not be familiar with these new recommendations.After…
Maphalle LNF, Michniak-Kohn BB, Ogunrombi MO, Adeleke OA
Managing pediatric tuberculosis (TB) remains a public health problem requiring urgent and long-lasting solutions as TB is one of the top ten causes of ill health and death in children as well as adolescents universally. Minors are particularly susceptible to this severe illness t…
Joana Vieira, Andreia Fiúza Ribeiro, Paula Correia, Helena Loureiro
Background: Tuberculosis disease under six years is an indicator of recent transmission within the community. We aim to characterize tuberculosis disease in children under six years in a pediatric department of a level II hospital in the Lisbon metropolitan area, which serves a h…
Robert Sinurat
Tuberculosis myelitis usually impacts adult patients and is associated with tuberculous meningitis, miliary tuberculosis, or human immunodeficiency virus infection. Pediatric tuberculosis myelitis cases without any associated diseases have never been reported. The author reported…
Raizada N, McDowell A, Parija D, Sachdeva KS, Khaparde SD, et al.
Background A significant proportion of pediatric tuberculosis (TB) patients go unnotified due to the challenges in diagnosis of TB among children. The experiences of this vulnerable group while going through the TB care cascade remain largely undocumented. The aim of this study w…
Caroline Lacroix, Philippe Martin, Sebastien Turcotte, Steven DeRoche, Vanessa Magluilo, et al.
…TION: Despite being more prevalent in developing countries, tuberculosis (TB) remains an important health problem in Canada. Long diagnosis delays of respiratory tuberculosis are associated with adverse consequences for the patient but also for the community. From a public health…
Bárbara Maitee Carmenates-Álvarez, Ana Dianelis Reyes-Escobar, Yosvany Rojas-Peláez, Yamilka Joamis Peña-Borroto, Yon Luis Trujillo-Pérez
Background: tuberculosis is a public health problem to a world scale. It is a systemic illness that can rarely affect the gastrointestinal tract and it is not very frequent in pediatrics. Its diagnosis constitutes a great challenge. Objective: to present the case of an adolescent…