Showing 176–200 of 200 documents
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Ruesen C, Riza AL, Florescu A, Chaidir L, Editoiu C, et al.
Mycobacterium tuberculosis drug resistance poses a major threat to tuberculosis control. Current phenotypic tests for drug susceptibility are time-consuming, technically complex, and expensive. Whole genome sequencing is a promising alternative, though the impact of different dru…
Callistus A. Akinleye, Adekola O. Adekunle, A. Onabule, Olugbenga Adekunle Olowe, Olusoji Daniel
… tuberculosis has left everlasting scars on people’s lives. Drug-resistant tuberculosis is becoming an increasingly serious hazard to public health. With over 240,000 fatalities due to drug-resistant tuberculosis (DR-TB) worldwide, and Nigeria is one of the 14 nations with a sign…
Vinayak Talwar, Abhishek Sadasivan
…e global TB elimination without TB elimination in SEAR, and drug resistance is a significant obstacle to the elimination of TB.[4] Drug-resistant TB is brought on by either the spread of Mycobacterium tuberculosis strains that are already resistant or by the inadequate treatment …
Parissa Farnia, Ali Akbar Velayati
With worldwide increases of rifampicin resistance, the World Health Organization (WHO) comes with a new definition of pre-extensively drug-resistant tuberculosis (XDR-TB) and XDR-TB. New definitions for pre-XDR and XDR-TB helped to define more precisely groups of TB patients who …
Ifrah Amjad, Saba Riaz
…rganisms. Microorganisms have noteworthy amplitude to offer resistance to antimicrobial agents and becoming an awful public health plight. The rising probability of infections is attributed to the ability of microbes conferring drug resistance. Drug resistance is a horrible capac…
Manita Yimcharoen, Sukanya Saikaew, Usanee Wattananandkul, Ponrut Phunpae, Sorasak Intorasoot, et al.
…mains a global health concern because of the development of drug resistance. The adaptability of MTB in response to a variety of environmental stresses is a crucial strategy that supports their survival and evades host defense mechanisms. Stress regulates gene expression, particu…
Mandira Varma‐Basil
Aims and objectives: Multidrug resistant TB (MDR-TB) and extensively drug resistant (XDR) are responsible for significant obstruction to global control of tuberculosis (TB). Drug resistance in Mycobacterium tuberculosis mainly occurs through chromosomal mutations in genes encodin…
Pedro Gomes, Paulo Paixão, Fernando Maltez, Laura Brum, Jody E Phelan, et al.
…tuberculosis (TB) in Western Europe and, historically, multidrug-resistant (MDR) cases have been strongly associated withstrains pertaining to the endemic Q1 and Lisboa3 clades. Notwithstanding, the contribution of drug resistance-associated allelic configurations in these clades…
Yitagesu Habtu, Tesema Bereku, Girma Alemu, Ermias Abera
…iopia is one of among thirty high burden countries of multi-drug resistant tuberculosis (MDR-TB) in the regions of world health organization. Contextual evidence on the emergence of the disease is limited at a program level. </sec> <sec> <title>OBJECTIVE</title> The aim of the st…
Noorsuzana Mohd Shariff, Shamsul Azhar Shah, Fadzilah Kamaludin
…ients had a significant contribution to the transmission of drug-resistant tuberculosis in the community. However, little is known about the profile of foreign-born drug-resistant patients in Malaysia, and this has become the aims of this current study. Methods and materials: Thi…
Anderson K, Pietersen E, Dheda K, van der Heijden YF
Background Simplified drug-resistant tuberculosis (DR-TB) treatment outcome definitions, mostly centred around receipt of treatment and sputum culture status at 6 months after treatment initiation, have been proposed, but have not been widely evaluated in resource-limited setting…
Balaji Zacharia, Antony Roy
…the increased prevalence of HIV infection. The incidence of drug resistance strains of mycobacterium is also on the rise. When the mycobacterium is resistant to both INH and rifampicin it is called multi drug resistant tuberculosis. There is a primary and an acquired type of drug…
Yunusbaeva M, Borodina L, Alekseev P, Davydov R, Yunusbaev U, et al.
…ountries, is characterized by one of the highest burdens of drug-resistant tuberculosis. Published data on the drug-resistant tuberculosis for these countries are limited, and it is not clear whether current treatment regimens remain effective against constantly evolving drug-res…
Durgadevi Ravi, Vishwanath kaliyaperumal, Bhuvaneswari Gunasekar, Shyamaladevi Babu
… health crisis, with millions of cases and deaths annually. Drug-resistant strains like multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB further complicate treatment. Conventional TB treatment, reliant on lengthy drug regimens, faces issues of non-compliance, dru…
A. A. Zhurilo, A. I. Barbova
The continued rise in the prevalence of multidrug-resistant and extensively drug-resistant tuberculosis in the era of human immunodeficiency virus infection poses a serious threat to effective tuberculosis control. Drug resistance in M. tuberculosis occurs due to lowfrequency spo…
Yani Jane Sugiri, Rezki Tantular, Silvy Amalia Falyani, Uray Riki Arif Maulana
…evolving in order to resist treatment. This has resulted in drug-resistant tuberculosis, which has a greater rate of therapy failure and mortality, as well as the necessity for other ways of disease transmission prevention. Pre-extensively drug-resistant tuberculosis (Pre-XDR TB)…
Khaoula Balgouthi, Emel Eker, Manaf AlMatar, Osman Albarri, Işil Var
Anti-tuberculosis activity and resistance were recently refocused since clofazimine (CFZ) had a significant therapeutic benefit in treating multi-drug resistant tuberculosis (MDR-TB). We investigate the resistance of CFZ and genetic mutations in drug-resistant Mycobacterium tuber…
Kyla Sherwood, Shom Dasgupta-Tsinikas, David L Fuller
Abstract Background Prompt identification of drug-resistant tuberculosis (DR-TB) is crucial for the timely initiation of effective therapy, but phenotypic drug susceptibility testing (pDST) takes weeks to provide results. Advanced molecular drug susceptibility testing (mDST) allo…
Deepika Rai, Priyanka Padwal, Priyanka Purkayastha, Sarika Mehra
ABSTRACT Resistance to multiple drugs is one of the significant barriers in the treatment of tuberculosis (TB). Knowledge of mechanisms of resistance is important to design effective treatment strategies. While mutations in genes coding for drug targets are thought to be the prim…
Dirie AMH, S Çolakoğlu, Abdulle OM, Abdi BM, Osman MA, et al.
…ospital, Mogadishu, Banadir, Somalia; 2Manager of the Multi-Drug Resistant Center in Southern Somalia, Mogadishu, Banadir, Somalia; 3HIV Program manager, Ministry of Health, Somali Federal Government, Mogadishu, Banadir, Somalia; 4Infectious and Microbiology Department, Somalia M…
Ogari CO, Nyamache AK, Nonoh J, Amukoye E
…as to determine the prevalence of mutations responsible for drug resistance in Mycobacterium tuberculosis among patients visiting selected health centers in Nairobi, Kenya. Methods The cross-sectional study involved 132 TB positive patients visiting Mbagathi and Chandaria hospita…
Nguyen QH, Contamin L, Nguyen TVA, Bañuls AL
At present, the successful transmission of drug-resistant Mycobacterium tuberculosis , including multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, in human populations, threatens tuberculosis control worldwide. Differently from many other bacteria, M. tuberc…
Maladan Y, Krismawati H, Wahyuni T, Tanjung R, Awaludin K, et al.
…ll becomes a burden for many countries including Indonesia. Drug resistance is one of the problems in TB treatment. However, a development in the molecular field through Whole-genome sequencing (WGS) can be used as a solution in detecting mutations associated with TB- drugs. This…
Paulina M. Mejía‐Ponce, Elsy Janeth Ramos-González, Axel Alejandro Ramos-García, Edgar E. Lara‐Ramírez, Alma R. Soriano-Herrera, et al.
…es worldwide. New diagnostic tools and approaches to detect drug-resistance must be introduced by 2025 to achieve the End-TB Strategy goals set for 2030 by the WHO. Genomic epidemiology of TB has allowed the expansion of catalogs listing genetic signatures of Mtb drug-resistance.…
Askar Zetov, Kulakhmed Erimbetov, Nargiza Parpieva, Bolat Zhetibayev, Abzal Malbaskanov
… a surgical approach in treatment of multi- and extensively drug-resistant tuberculosis.Design:The article described a retrospective analysis of surgical treatment of 246 multi- and extensively drug-resistant tuberculosis patients who were divided into 3 groups: 152 multi-drug-re…