Showing 176–200 of 200 documents
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Eric R Houpt, MD
…sary. DNA samples will be further analyzed at the Institute Epidemiology and Microbiology/Russian Academy of Medical Sciences in Irkutsk. The subset of subjects positive for M. tuberculosis and initiating TB treatment at the Irkutsk Dispensary will have pharmacokinetic sampling (…
Anisha Shree Venugopal, Safana Safreen Sirajudeen, BEGAYIM SOVETBEKOVNA MUSAEVA
…carried out. Included were studies on therapeutic outcomes, epidemiology, pathogenesis, and diagnostics. Results: PTB typically presents with persistent cough, fever, night sweats, weight loss, and hemoptysis. Diagnosis relies on sputum microscopy, culture, rapid molecular tests,…
Anisha Shree Venugopal, Safana Safreen Sirajudeen, BEGAYIM SOVETBEKOVNA MUSAEVA
…carried out. Included were studies on therapeutic outcomes, epidemiology, pathogenesis, and diagnostics. Results: PTB typically presents with persistent cough, fever, night sweats, weight loss, and hemoptysis. Diagnosis relies on sputum microscopy, culture, rapid molecular tests,…
Shadow Bee
This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/17993130. Summary This preprint evaluates the performance of the Xpert MTB/XDR assay for rapid detection of drug resistance in Mycobacterium …
Shadow Bee
This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/17993130. Summary This preprint evaluates the performance of the Xpert MTB/XDR assay for rapid detection of drug resistance in Mycobacterium …
Taiwo Isaac Olatunji, M.M. Suleiman, Olatunji Matthew Kolawole
…sources of novel anti-TB compounds. This paper explores the epidemiology of TB, the urgent need for new therapeutic agents, and the scientific basis for ethnomedicinal plants traditionally used in Nigerian communities to manage TB symptoms. Empirical data highlight the antimicrob…
Naresh Kumar Jothi, A. Lakshmi
Drug-resistant strains of tuberculosis, such as MDR-TB (multidrug resistant tuberculosis) and XDR-TB (extensively drug-resistant tuberculosis), are a major cause of worry since they continue to be a top cause of death globally despite significant advancements in prevention and tr…
Usman Ali
…eatment. This review offers a comprehensive analysis of the epidemiology, pathogenesis, diagnosis, treatment, and prevention strategies for MDR and XDR TB. It highlights existing research gaps and proposes future directions to address these challenges. Advances in Artificial Inte…
Parissa Farnia, Ali Akbar Velayati
With worldwide increases of rifampicin resistance, the World Health Organization (WHO) comes with a new definition of pre-extensively drug-resistant tuberculosis (XDR-TB) and XDR-TB. New definitions for pre-XDR and XDR-TB helped to define more precisely groups of TB patients who …
Vinayak Talwar, Abhishek Sadasivan
Sir, Tuberculosis (TB) is a preventable and curable infectious disease caused by the bacteria Mycobacterium tuberculosis. It affects the lungs but can also spread to other parts of the body. TB is transmitted through the air when an infected person coughs, sneezes or speaks. The …
Lindiwe Modest Faye, Mojisola Clara Hosu, Yanga Mbiza, Nomzi Lubuzo, Ncomeka Sineke, et al.
Multidrug-resistant tuberculosis emerged as a serious challenge to tuberculosis management and control. In the Eastern Cape, the Beijing variants are prevalent and a driving force of multidrug-resistant tuberculosis; hence, we investigated the distribution of gene mutations in Be…
Muhammad Fachri, Mochammad Hatta, Firda Muthi Ubaidah, Risky Akaputra, Ressy Dwiyanti, et al.
Abstract Background: Pulmonary TB and DM are a combination of high medical-epidemiological conflict and high global impact because they are interdependent. Pulmonary TB cannot improve in the presence of unmanaged diabetes. Pulmonary TB in people with DM has particular characteris…
Tetiana Butova, M Kuzhko, O Solodiankin, N Rudova, Anton Tkachenko, et al.
We studied the variability of resistance of MTB for MDR/XDR-TB patients in the Kharkiv region,Ukraine, based on full genome sequencing and drug-sensitivity test (DST) data. <b>Methods:</b> Bacterial DNA was isolated from 223 patient samples. Following the complete genome sequenci…
Nicolas Véziris, Isabelle Bonnet, F. Morel, Lorenzo Guglielmetti, Thomas Maitre, et al.
…retrospectively the impact of the revised definition on the epidemiology of XDR-TB in France. The revised WHO definition of XDR-TB decreases the number of TB cases classified as such, and allows better focus on the most difficult to treat cases of TB <https://bit.ly/3tgaXQA> We t…
Pradeep M Muragundi
…re in treatment and mortality rate also high jeopardize for epidemiology. Its prevalence is unknown in India as there was no nationwide counselling. Globally, there were an estimated 55,100 new extensively drug resistant tuberculosis cases in the year of 2015 in 117 countries. Ho…
Zejin Ou, Danfeng Yu, Yuanhao Liang, Wenqiao He, Yongzhi Li, et al.
Abstract Background Antituberculosis-drug resistance is an important public health issue worldwide, and its epidemiological patterns has dramatically changed in recent decades. This study aimed to estimate the trends of multidrug-resistant tuberculosis (MDR-TB), which can provide…
Pankaj Jorwal, Anivita Aggarwal, Parul Kodan, Nitin Gupta, Sudeshna Ghosh, et al.
…(all except capreomycin). This study aimed to delineate the epidemiology of XDR-TB and outcomes associated with the long-term standardized treatment regimen. This was a retrospective review of treatment charts of patients diagnosed with drug-resistant tuberculosis at our institut…
Simon Tiberi, Giovanni Battista Migliori, Jeremiah Chakaya, Tereza Kaesava, Seif Al-Abri, et al.
…holar). Keeping up to date on the latest developments of TB epidemiology, diagnostics, treatment regimens is vital for continuing medical education (CME) and continuing professional development (CPD). For achieve this, update courses with the latest developments are important, es…
Ariadna Petronela Fildan
Rapid detection of Mycobacterium tuberculosis (MTB) chemoresistance against anti-tuberculosis drugs is a major challenge of any Pulmonology department. The aim of the study was to synthesize the epidemiological features of multidrug resistant (MDR), rifampicin resistant (RR) or e…
Jeong Seong Yang, Hyeonji Kim, Minji Kang, Seung Heon Lee, Dong Yeon Shin, et al.
Background As a recommendation for the treatment of multidrug-resistant (MDR) / rifampicin-resistant tuberculosis (RR) in WHO guidelines, the use of linezolid is strongly recommended for longer MDR-TB regimens. However, there are many reports of side effects from using linezolid.…
Andrea Sanchini, Christine Jandrasits, Julius Tembrockhaus, Thomas A. Kohl, Christian Utpatel, et al.
Abstract Introduction Improving the surveillance of tuberculosis (TB) is especially important for multidrug-resistant (MDR) and extensively drug-resistant (XDR)-TB. The large amount of publicly available whole-genome sequencing (WGS) data for TB gives us the chance to re-use data…
A Cannas, O Butera, G Gualano, Parracino MP, C Venditti, et al.
… “L. Spallanzani” IRCCS, Rome, Italy; 3Clinical Epidemiology Unit, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, Rome, Italy*These authors contributed equally to this workCorrespondence: A CannasNational Institute for Infectious Diseas…
Kristin Nelson, Neel R. Gandhi, Barun Mathema, Benjamin A. Lopman, James C.M. Brust, et al.
ABSTRACT The transmission patterns of drug-resistant tuberculosis (TB) remain poorly understood, despite over half a million incident cases in 2017. Modeling TB transmission networks can provide insight into the nature and drivers of transmission, but incomplete and non-random sa…
Peter J. Holmberg, Zelalem Temesgen, Ritu Banerjee
… this article, readers should be able to: 1. Understand the epidemiology of pediatric tuberculosis (TB). 2. Describe the mechanisms of TB acquisition and host response, including T-cell–mediated actions and granuloma formation. 3. Discuss the importance of comorbid conditions, sp…
David S.C. Hui, Chi Chiu Leung
Respiratory tract infections (RTI), such as community-acquired pneumonia (CAP) and tuberculosis (TB), are important causes of morbidity and mortality. The ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) infection and epidemic waves of avian influenza …