Showing 176–200 of 200 documents
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Sibhat MM, Mulugeta TN, Aklilu DW
….07], suboptimal adherence [AHR = 2.10; 95% CI: 1.12-3.92], drug toxicity [AHR = 7.05; 95% CI: 3.61-13.75], advanced latest clinical stage [AHR = 2.75; 95%CI: 1.05-7.15], and tuberculosis co-infection at baseline [AHR = 3.08; 95%CI: 1.26-7.51] were significantly associated with s…
Xiaoyan Wang, M L Jiang, Yuanjie Pang, Dianjianyi Sun, Canqing Yu, et al.
…estern regions. In addition, latent tuberculosis infection, drug-resistant tuberculosis, tuberculosis coinfection with HIV, and extrapulmonary tuberculosis have also exacerbated the disease burden of tuberculosis to some extent. This paper reviewed the epidemic characteristics of…
Flynn AG, Aiona K, Haas MK, Reves R, Belknap R
…ed for latent tuberculosis we found no evidence of acquired drug resistance, underscoring the safety of rifampin monotherapy for latent tuberculosis.
Zhang H, Liao Y, Zhu Z, Liu H, Li D, et al.
… severe combined immunodeficiency (X-SCID). M.bovis and its drug resistance genes were identified by metagenomics next-generation sequencing (mNGS) combined with targeted next-generation sequencing (tNGS) in blood and cerebrospinal fluid. Whole exome sequencing (WES) revealed a p…
Mohamed E. El Zowalaty, Hossam M. Ashour
…use and the emergence of spreading, multiple, and extremely drug-resistant Mtb. In addition, the only approved TB vaccine is the current vaccine Bacille Calmette-Guérin (BCG), which provides partial and variable protection. Currently, there are at least 16 candidate vaccines in v…
Natacha Njike Ngongang, Cybelle Fodieu Mezajou, Charleine Kameni, Jubilate Afuoti Ngum, Ulrich Stephane Fotso Simo, et al.
… globally and in developing countries with the emergence of drug-resistant Mycobacterium tuberculosis strains. Long non-coding RNAs (lncRNAs) are promising tuberculosis diagnostic biomarkers. Two lncRNA diagnostic markers, lncRNA THRIL and lincRNA-p21, were studied as tuberculosi…
S Praveen Raj Dr. Anitha S Menon
…ease in the number of TB cases, death and the proportion of drug- resistant TB. Here, we present six cases of <em>Mycobacterium tuberculosis </em>infection out of which five patients never had history or exposure to TB bacteria. This raises a concern to the TB syndemic since the …
Tjale MA, Ombinda-Lemboumba S, Maphanga C, Mthunzi-Kufa P
…se continues to present a major global health challenge and drug resistance is continuously growing. TB is caused by Mycobacterium tuberculosis and spreads exclusively via human-to-human contact transmission. Therefore, early detection and diagnosis for proper treatment with acti…
Marie‐Claire Rowlinson, Kimberlee A. Musser, Reeti Khare
… MTBC strains was limited to mycobacterial phage typing and drug resistance patterns, methods which have low discriminatory power that have been replaced by molecular genotypic methods. Antimicrobial susceptibility testing is a critical element of the MTBC laboratory workup. Whil…
Marie‐Claire Rowlinson, Kimberlee A. Musser, Reeti Khare
… MTBC strains was limited to mycobacterial phage typing and drug resistance patterns, methods which have low discriminatory power that have been replaced by molecular genotypic methods. Antimicrobial susceptibility testing is a critical element of the MTBC laboratory workup. Whil…
Nasiri MJ, Venketaraman V
…ors, hold promise for improving TB management and combating drug-resistant strains. Despite these advancements, significant challenges remain, including the development of effective vaccines; addressing latent TB; and ensuring equitable access to novel treatments. The integration…
Ainharan Raveendran, Anish Keepanasseril, Ravi Kumar Balu, Ashalatha Shetty, Mahendran Chetty
…agement of active tuberculosis, including management of any drug resistance. To understand management of the neonate within high‐risk groups and where the mothers have diagnosed latent or active TB. Ethical issues Pregnant women with TB should be fully counselled about the benefi…
MRaveendran Nair
…nts to ensure the key aspects such as the supply of anti-TB drugs, monitoring, evaluation, and national level surveillance. TUBERCULOSIS AND HIV The interrelationship between TB and HIV/AIDS is well established. People living with HIV are about 29 times more vulnerable to develop…
Mannebach K, Dressel A, Eason L
…nd environmental regulation). Given concerns with extremely drug resistant TB and because infectious diseases can permeate National borders, public health nurses, and other healthcare professionals must educate themselves and advocate on behalf of vulnerable populations such as c…
Abdul Razzaq Malik
… year in Pakistan. Among these about, 15 000 are developing drug resistant TB cases. Pakistan is bearing 61% of the TB burden in the EMRO. Tuberculosis is preventable and curable disease. The causative agent of tuberculosis, Mycobacterium tuberculosis, most often affect the lungs…
Angela Hidalgo-Gajardo, Bryan Mangui, Carla Villavicencio, Jorge R Toledo, Frank Camacho
…eatment is long, complex, and conducive to the emergence of drug-resistant strains. In this context, heat shock protein X (HspX), also known as Rv2031c or α-crystallin, has emerged as a potential biomarker and vaccine candidate. This 16-kDa protein is predominantly expresse…
Lai WA, Brethour K, D'Silva O, Chaisson RE, Zwerling AA
…. We excluded posters and abstracts, treatment for multiple drug resistant tuberculosis, and combined testing and treatment strategies. We then restricted our findings to studies examining directly-observed 3HP for comparison. The primary outcome was the cost and cost-effectivene…
Qi Y, Li K, Li Y, Guo D, Xu J, et al.
…e than 23% of the world's population. With the emergence of drug-resistant TB (DR-TB) and latent TB infection (LTBI), rapid diagnosis of DR-TB and LTBI has become a challenge for the prevention and control of TB. Herein, we highlight these challenges and discuss emerging clustere…
Chakraborty B, Laskar AA, Baruah A, Kumar R, Barbhuiya MA
…on early detection, management of latent TB, and control of drug resistance are critical. This review explores global guidelines, highlights implementation challenges, and suggests pathways for achieving effective TB control in India.
Deepak V. Sawant, Shivaji H. Pawar
… high in developing nations, where diagnosing of latent TB, drug-resistant TB, and HIV co-infected, pediatric TB remains still a challenge. There are so many low sensitive conventional TB diagnosis methods are available which are responsible for delay in early-stage TB diagnosis.…
Vadim Nikitushkin, Margarita O. Shleeva, Dmitry S. Loginov, Filip Dyčka, Ján Štěrba, et al.
…, in addition to low metabolic activity and a high level of drug resistance, are characterized by ‘non-culturability’ – a specific reversible state of the inability of the cells to grow on solid media. The biochemical characterization of this physiological state of the pathogen i…
Rafael S. Pereira, Chris T. Bauch, T. J. P. Penna, Aquino L. Espíndola
…s latent TB pathogens. Therefore, avoiding the emergence of drug-resistant strains has become a central issue in TB control. In this work, we propose a nested model for TB transmission and control, wherein both within-host and between-host dynamics are modeled. We use the model t…
Fa L, Xu C, Cheng J, Zhang H
… among high-risk groups with latent tuberculosis infection. Drug resistance, adverse events, and unguaranteed efficacy were three main barriers for healthcare workers in accepting TPT. What are the implications for public health practice? To further promote and implement TPT in C…
Guadalupe García-Elorriaga, Del Rey-Pineda Guillermo
…deliver faster findings than standard phenotypic culture in drug susceptibility testing. Furthermore, the results of tests that detect or quantify cytokines released during the inflammatory process in latent tuberculosis infection (LTBI), such as the Interferon-Gamma Release Assa…
Roxana Rustomjee
…ating impact of the HIV-1 pandemic, the rising emergence of drug resistance as well as the growing disparity in disease burden between developed and developing countries. Progress has also been hindered by the slow development of more effective tools such as point-of-care diagnos…