Showing 151–175 of 200 documents
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Ibrahim Khalil, Noshin Anjum Tasmi, Md Imran Hossain, Mst Mahmuda Akter
**BACKGROUND:** HIV/AIDS and multidrug-resistant tuberculosis (MDR-TB, non-extensively drug-resistant) together cause significant mortality in Africa, home to 67% of the 39 million people living with HIV globally and 2.5 million TB cases in 2022. This study analyzes Global Burden…
Ketan N Malu, Jeffrey A. Tornheim, Amita Gupta, Girija Kishore, Zarir Udwadia
…ian age of 26 years. 407 had pulmonary TB (78.7%) and 3 had HIV (0.6%). Hypothyroidism was the most common side effect (N=320, 61.9%) followed by kidney injury (N=131, 25.3%), dark skin (N=111, 21.4%), peripheral neuropathy (N=100, 19.3%), hearing loss (N=88, 17.0%) and nausea (N…
Olatunde Olayanju
… these drugs in drug-resistant TB patients, with or without HIV infection, from a real-life programmatic setting are lacking. This thesis aims to address that knowledge gap and provide information for management of drug-resistant TB in countries with high disease burden. Methods:…
Francesca Conradie
… element to allocate participants evenly across the arms by HIV status and type of TB. Each participant will receive 26 weeks of treatment. If participant's week 16 sputum sample is culture positive between the week 16 and week 26 treatment visits and their clinical condition su…
Ricardo Cordeiro, M.J. Cavaco, Carina Rôlo Silvestre, André Nunes, João Otávio de Queiroz Araujo, et al.
…s:</b> The index case was a 34 years old male, drug‑addict, HIV positive, with XDR-TB in 2010 (DST revealed resistance to H, R, Z, E, S, Am, Cm, Eto, Ofx; and sensitivity to PAS, Cs and Lzd). Initial screening of close contacts identified 4 adults and 3 children- all of the…
Sahak Mkrtchyan
…e diagnostic complexity of CNS TB in patients with advanced HIV infection and multiple viral coinfections and highlights the critical role of early neuroimaging and coordinated care.
Muhammad Akram, Abid Mahmood, Mohammed Khudhair Hasan, Isaac John Umaru, Hind A. Abdulghafoor, et al.
…oeconomic determinants including poverty, malnutrition, and HIV co-infection, tuberculosis (TB) continues to be a major cause of morbidity and death even though it is preventable and treatable. Bacterial evasion mechanisms and the host immune response interact intricately in the …
Adeniji AA, Knoll KE, Loots DT
… drug-resistant (DR) TB and comorbidities with diabetes and HIV. Exiguous dosing, incomplete treatment course, and the ability of the tuberculosis bacilli to tolerate and survive current first-line and second-line anti-TB drugs, in either their latent state or active state, has r…
Abdul Rashid dayo, Shahzad Memon, Yar Muhammad Tunio, Kashif Ali, Maria Basheer, et al.
Objective: To determine the frequency of HIV infections in patients with pulmonary tuberculosis. Patients and methods: This cross-sectional study, was conducted at the Department of Medicine, Ghulam Muhammad Mehar Medical College, Sukkur, from October 2019 to 2020. All the patien…
Bei C, Fu M, Zhang Y, Xie H, Yin K, et al.
…nd associated risk factors of Human Immunodeficiency Virus (HIV)-negative patients with XDR-TB in China. Methods All patients who were diagnosed with XDR-TB for the first time in four TB care centers across China between March 2013 and February 2015 were consecutively enrolled. A…
Briceno RK, Sergent SR, Benites SM, Alocilja EC
…sis (TB) is the leading cause of death globally, surpassing HIV. Furthermore, multidrug-resistant and extensively drug-resistant TB have become global public health threats. Care of TB patients starts with quality, accessible, and affordable diagnosis. The study presents a novel …
Olayanju O, Limberis J, Esmail A, Oelofse S, Gina P, et al.
…prospectively followed-up 272 South African patients (49.3% HIV-infected; median CD4 count 169 cells·µL -1 ) with newly diagnosed XDR-TB between 2008 and 2017. Outcomes were compared between those who had not received bedaquiline (pre-2013; n=204) and those who had (post-2013; n=…
Desai U, Joshi JM
…R-TB) on DST. Thirteen (17.11%) had comorbidities. None had HIV. Two (2.63%) had DM. Patients were treated as per the revised TB control program - programmatic management of DR-TB guidelines. Duration of intensive (IP) was 6.55 (1.22) months. Ten (13.2%) received shorter regimens…
Aliya, Muhammad Waqar Ali, Tuba Alim, Akhter Nawaz, Umbreen Farrukh, et al.
… < 0.001). MDR-TB was also significantly associated with HIV co-infection (p = 0.02), irregular treatment adherence (p = 0.001), and known contact with MDR-TB cases (p = 0.03). Additional resistance to ethambutol and streptomycin was noted in 31.9% and 25.5% of MDR-TB patients…
Saad Alghamdi, Naeem F. Qusty, Saad Alghamdi, Anas S. Dablool, Sheetal Verma, et al.
… also a leading cause of mortality among people living with HIV, accounting for one in three HIV-related deaths. The emergence and spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis strains now threaten global TB control efforts. C…
Sipho H. Chauke, Saturnin Ombinda‐Lemboumba, Felix S. Dube, Patience Mthunzi‐Kufa
…nd in patients with human immunodeficiency virus infection (HIV). There are currently several rapid TB diagnostics, but most are limited due to costs and accessibility. Several genes, such as <i>catalase-peroxidase</i> (<i>kat</i>G) and <i>enoyl reductase</i> (<i>inh</i>A) genes,…
Ricardo Cordeiro, André Nunes, Carina Rolo, Daniel Duarte, Natália André, et al.
…e index case (case 1) was a 34 years old male, drug‑addict, HIV positive, with pulmonary and meningitis TB diagnosed in 2000 - M.tuberculosis with Susceptibility testing (DST) showing susceptibility to all first-line drugs. In 2010 he was diagnosed XDR-TB with relapse in 2012 (DS…
Simon Tiberi, Giovanni Battista Migliori, Jeremiah Chakaya, Tereza Kaesava, Seif Al-Abri, et al.
…(4) Google Scholar). The TB prevalence among newly enrolled HIV-infected patients during the study period was 13.4% (22/164) in Guinea Bissau (Aunsborg et al., 2020Aunsborg J.W. Hønge B.L. Jespersen S. Rudolf F. Medina C. Correia F.G. et al.A clinical score has utility in tubercu…
Arnaud Iradukunda, Gabin NDAYISHIMIYE, Darlene Sinarinzi, Emmanuel Nene Odjidja, Nestor Ntakaburimvo, et al.
… TB treatment history(86.4%) and in diabetics people(66.6%).HIV was 32.3% and 67.7% positive respectively in MDR-TB patients and Drug susceptible patients. More than half of cases (75%) and controls (73.3%) belonged to the age group of ≤ 45 years.The Pearson's Chi-squared test wi…
Alexandra V Solovyeva, Grigory V Volchenkov, Oksana I Ponomarenko, Tatiana A Kuznezova, Tatiana R Somova, et al.
…contacts, people experiencing homelessness, and people with HIV who received TPT in Vladimir between 2019 and 2020. Those without TB disease but with indications for TPT were offered 1 of 6 regimens, based on drug-susceptibility testing results of the index patient: rifapentine/i…
Montiel Quezel-Guerraz N, Sánchez-Porto A, Ortega Torres M, Pérez Santos MJ, Acosta F, et al.
…nto account patient age, sex, human immunodeficiency virus (HIV) infection, country of birth and prior anti-TB treatment. Results TB was found more frequently in men than in women (66.6% vs. 33.4%), and the age group with the most cases (43.7%) was 36-55 years. Among the first-li…
Diti V Gandhasiri, Tilak Dhamgaye, Ulhas Jadhav, Babaji Ghewade
…seminated TB is well known as an opportunistic infection in HIV infected individuals, it is uncommon in HIV negative individuals. The present case is a rare case of Extensively Drug Resistant (XDR)-TB in disseminated TB involving the extrapulmonary sites in an immunocompetent adu…
Nizar A. Khamjan, Heena Tabassum, Elhan Khan, Mohtashim Lohani, Md. Mazharul Haque, et al.
…strains (MDR and XDR TB) develops and its co-infection with HIV AIDS. There is a serious need to investigate and develop novel, cost-effective and potent anti-TB drugs. There is a requirement for the evaluation of the herbal drugs by standard scientific methods so as to validate …
World Health Organization. Regional Office for Europe
…arters Global TB Programme and from the Joint Tuberculosis, HIV and Viral Hepatitis Programme of the WHO Regional Office for Europe took part in the training session. During the meeting, staff and core experts from the WHO Regional Office for Europe and rGLC experts shared update…
A. S. (Abdullaeva) Sh
…B-endemic countries and a third of deaths among people with HIV infection. These facts make it possible to classify TB as a disease with a high mortality rate in the adult population. The scale of the TB problem is further aggravated by the evolution and global spread of Mycobact…