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Nelly Jinga, Kamban Hirasen, Olena Ivanova, Andrea Rachow, Salome Charalambous, et al.
…gies. Logistic regression indicated that males, living with HIV and being on antiretroviral treatment (ART), being impacted financially during COVID-19, and experiencing social changes, were associated with poor health-seeking behaviour. **CONCLUSION:** Governments' response to …
Workie MG, Aycheh MW, Birhanu MY, Tsegaye TB
…l medicine (AOR = 2.35, 95% CI 1.05-5.24); co-infected with HIV (AOR=1.58, 95% CI; 1.85-4.29), and waiting time at the health facility ≥30 minutes (AOR = 2.98, 95% CI; 1.31-6.80). Conclusion Alcohol consumption, waiting time at the health facility ≥30 minutes, smoking habits, use…
Kim HW, Min J, Ko Y, Oh JY, Jeong YJ, et al.
Introduction In South Korea, public-private mix (PPM) has been a key strategy in national tuberculosis (TB) control program. This study aimed to identify rate of loss to follow-up (LTFU) among TB patients in nationwide PPM institutions and their risk factors. Methods A nationwide…
Linda prof
The goal of this randomized controlled trial is to evaluate the early bactericidal activity, early inflammatory response, and safety of omega-3 long chain polyunsaturated fatty acid (n-3 PUFA) supplementation in adult patients (aged 18- 45 years) with newly diagnosed, bacteriolog…
Munish Rastogi
…s low (12.6%), and none of these patients were positive for HIV. Majority of the chest radiographs showed non-cavitary pulmonary infiltrates (94.4%), and cavities were seen in only (8.9%) of cases. More than half of the patients belonged to low-income groups. DISCUSSION The resul…
Brittney Sweetser, Esin Nkereuwem, Jascent Nakafeero, Marie Gomez, Peter Wambi, et al.
…rs (IQR 1-7), 56.6% were female, and 13.2% were living with HIV. In all children with PTB, Xpert-HR achieved an AUC of 0.67 (95% CI 0.55-0.78), with 89.3% sensitivity (95% CI 71.8-97.7) and 29.5% specificity (95% CI 19.7-40.9, cutoff ≤ -0.60). By confirmation status, …
Simone Villa, Giovanni Battista Migliori, Lia D’Ambrosio, Mario Raviǵlione
… diseases after COVID-19, the first among those living with HIV. If timely diagnosed and effectively treated, the disease is curable, especially when caused by drug-susceptible strains. In the past three decades, numerous efforts have been made to control and, eventually, elimina…
Álvaro H Borges, Marisa Russell, Dereck Tait, Thomas J Scriba, Elisa Nemes, et al.
…l site), we enrolled participants aged 18-60 years, without HIV, who had completed more than 5 months (22 weeks) of treatment for drug-susceptible pulmonary tuberculosis. During trial screening (≤7 days after starting treatment), two sputum samples were obtained and frozen…
Radojka Savic, PharmD, PhD, Kelly Dooley, MD, PhD, Gustavo Velásquez, MD, MPH
A5409/RAD-TB is an adaptive Phase 2 randomized, controlled, open-label, dose-ranging, platform protocol to evaluate the safety and efficacy of multidrug regimens for the treatment of adults with drug-susceptible pulmonary tuberculosis (TB). A5409 hypothesizes that novel regimens…
Edwards T, White LV, Lee N, Castro MC, Saludar NR, et al.
… (-0.45, 95% CI -0.88 to -0.01). In 225 patients with known HIV status in Metro Manila, HIV was associated with modestly reduced HrQoL ( P = 0.014). CONCLUSION: Nutritional status and food insecurity represent modifiable risk factors for poor HrQoL that may be alleviated through …
L.D. Todoriko, I. Margineanu, Ihor Semianiv, Fajri Gafar, Teodora Butnaru, et al.
Objective — to conduct a retrospective analysis of factors that affect the results of treatment of patients with tuberculosis. Materials and methods. A retrospective multi-center study was conducted on adult (> 18 years) patients diagnosed with drug-sensitive susceptible TB of…
Subbaraman R, Thomas BE, Kumar JV, Thiruvengadam K, Khandewale A, et al.
…tion refills (aOR, 6.6; CI, 1.5-29.5; P = .01). People with HIV reported greater barriers to collecting medications than non-PWH. Among 167 patients reporting missing doses, reported reasons included traveling from home, forgetting, feeling depressed, and running out of pills. Th…
Flávia M. Sant ́Anna, Mariana Araújo‐Pereira, Carolina Arana Stanis Schmaltz, María B. Arriaga, Raquel de Vasconcellos Carvalhães de Oliveira, et al.
….8% presented at least one ADR, 34% were people living with HIV (PLHIV). Most ADR were clinical (53%), early (82.5%), mild/moderate (88.7%) events and of “metabolic annutritional disorders” category. There were no significant differences in type, severity or causality between “ea…
Sunday Olakunle Olarewaju, Sunday Charles Adeyemo, Ayomide Timilehin Kayode, Janet Oluwaseyi Ayinmodu, Olushina Ololade Oladeji, et al.
…red to Tertiary level of education. Respondents living with HIV were 35 times more likely to develop depression (AOR = 35.303, P = 0.017) compared to those who were HIV negative.
Schoenbaechler V, Guilavogui Y, Onivogui S, Hébélamou J, Mugglin C, et al.
Objectives To analyze the treatment success rate (TSR = sum of cured or treatment completed) in the tuberculosis (TB) program for drug-susceptible TB (DS-TB) at the "Centre Hospitalier Régional Spécialisé" in Macenta, Forest Region, Republic of Guinea. Methods This cohort study i…
Susan Shin-Jung Lee, MD, PhD
Tuberculosis remains an important global health problem, and the world is currently not on track to end the TB epidemic by 2030. With the concerted efforts of the government and medical community, the incidence of TB in Taiwan has gradually decreased, however, Taiwan remains an e…
Ridolfi F, Peetluk L, Amorim G, Turner M, Figueiredo M, et al.
…o use (aOR = 2.9; 95% CI, 1.7-4.9), and being a person with HIV (PWH) (aOR = 2.0; 95% CI, 1.1-3.5). Treatment failure was associated with PWH (aOR = 2.7; 95% CI, 1.2-6.2) and having diabetes (aOR = 2.2; 95% CI, 1.1-4.4). Death was associated with anemia (aOR = 5.3; 95% CI, 1.4-19…
Veronique R de Jager, MD, Prof. Rodney Dawson, MD, Prof. Andreas Diacon
This trial will evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of multiple oral doses of OPC-167832 in participants with uncomplicated, smear-positive, drug-susceptible pulmonary tuberculosis (TB).
Djochie RDA, Anto BP, Opare-Addo MNA, Boakye-Yiadom J
…ncluded baseline body weight, weight gain during treatment, HIV status, adverse drug reactions, and mental well-being at treatment initiation. Multivariate analysis revealed that gaining at least 3 kg during treatment and having no risk of depression at baseline significantly inc…
Araújo-Pereira M, Nogueira BMF, Spener-Gomes R, Carvalho ACC, Sant'Anna FM, et al.
…at baseline. Patients with moderate/severe anemia were more HIV-seropositive, as well as more symptomatic and had higher frequencies of unfavorable outcomes compared to the other groups. Moderate/severe anemia (adjusted OR [aOR]: 7.80, 95 %CI:1.34-45.4, p = 0.022) was associated …
Michael Marll, Lungile Gabuza, Floyd B. Willis, Ana Angélica Rêgo de Queiroz, A. Rajaratnam, et al.
…hort in Johannesburg, South Africa, adults with and without HIV were enrolled within two weeks of initiating standard four-drug therapy for newly diagnosed, first-time episodes of drug-susceptible PTB. All participants had moderate-to-severe pulmonary disease based on chest x-ray…
Shenzhen Third People's Hospital
Tuberculosis (TB) remains one of the leading global public health concerns and is among the top ten causes of death from a single infectious agent. China ranks third worldwide in total TB burden, with a substantial proportion of cases classified as drug-susceptible TB (DS-TB). De…
Susan Dorman, MD, Payam Nahid, MD, MPH, Susan Swindells, MBBS, Richard Chaisson, MD, Ekaterina V Kurbatova, MD, PhD, MPH
…irenz-based antiretroviral treatment among patients with TB/HIV co-infection taking efavirenz-based combination antiretroviral therapy and TB treatment with rifapentine Endpoints: Primary Endpoints: * Efficacy: TB disease-free survival at twelve months after study treatment as…
Shenzhen Third People's Hospital
Tuberculosis (TB) remains a major public health issue and one of the top ten causes of death from a single infectious disease worldwide. China is among the countries with the highest TB burden, ranking third globally for total TB cases and second for drug-resistant TB cases. PAN-…
Morounfolu Olugbosi, MD
The goal of this clinical trial is to evaluate 3 dose levels of TBAJ876 for 8 weeks in combination with pretomanid and linezolid, compared to 8 weeks of Isoniazid, rifampicin, pyrazinamide and ethambutol (2HRZE), in adult participants with newly diagnosed, smear-positive, pulmona…