Showing 151–175 of 200 documents
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Araújo-Pereira M, Nogueira BMF, Spener-Gomes R, Carvalho ACC, Sant'Anna FM, et al.
Background Tuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity of anemia in PWTB prior to anti-TB treatment (ATT) was a risk factor for an unfavorable outcome. Methods Patients ≥ 18 years old with…
Sebastian J, Thomas A, Levine C, Shrestha R, Levy S, et al.
Initial responses to tuberculosis treatment are poor predictors of final therapeutic outcomes in drug-susceptible disease, suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting Mycobacterium tuberculosis population.…
Garcia-Contreras L, Hanif SNM, Ibrahim M, Durham P, Hickey AJ
CPZEN-45 is a novel compound with activity against drug-susceptible and drug-resistant tuberculosis (TB). The present study was undertaken to determine the best dose and dosing regimen of inhalable CPZEN-45 powders to use in efficacy studies with TB-infected guinea pigs. The disp…
Iskandar D, Suwantika AA, Pradipta IS, Postma MJ, van Boven JFM
…·21% to 43·68%. The costs of visits and monitoring and drug regimens were relatively stable, with total direct medical costs slightly increasing from US$39·40 to $40·40 per case. Interpretation Progress was made on drug-susceptible tuberculosis management in Indonesia. However, f…
Zhang J, Lair C, Roubert C, Amaning K, Barrio MB, et al.
…s TB clinical candidates, with the potential for use in new regimens against drug-susceptible and drug-resistant TB.
Saha S, Saxena D, Raval D, Halkarni N, Doshi R, et al.
Introduction Adherence to tuberculosis (TB) medication is one of the critical challenges to tuberculosis elimination in India. Digital adherence technologies (DAT) have the potential to facilitate medication adherence and monitor it remotely. Tuberculosis Monitoring Encouragement…
Fox WS, Strydom N, Imperial MZ, Jarlsberg L, Savic RM
Aims Adherence has been shown to be a major predictor of tuberculosis treatment failure and relapse. The current adherence metrics can be improved to provide higher resolution of adherence patterns and identify patients in need of alternative treatment interventions. We investiga…
Said B, Charlie L, Getachew E, Wanjiru CL, Abebe M, et al.
…es with drug-susceptible or resistance to anti-tuberculosis regimens. Despite of the high installing cost of the tuberculosis molecular bacterial load assay method, molecular expertise, and a well-equipped laboratory, tuberculosis molecular bacterial load assay is a cost-effectiv…
Musisi E, Dide-Agossou C, Al Mubarak R, Rossmassler K, Ssesolo AW, et al.
… (RS) ratio indicates the treatment-shortening of drugs and regimens. Distinct from traditional measures of bacterial burden, the RS ratio measures a fundamentally novel property, how drugs impact ongoing bacterial rRNA synthesis.
Peetluk LS, Rebeiro PF, Ridolfi FM, Andrade BB, Cordeiro-Santos M, et al.
Background Despite widespread availability of curative therapy, tuberculosis (TB) treatment outcomes remain suboptimal. Clinical prediction models can inform treatment strategies to improve outcomes. Using baseline clinical data, we developed a prediction model for unsuccessful T…
Khan A, Abbas M, Verma S, Verma S, Rizvi AA, et al.
Tuberculosis (TB) continues to be a major infectious disease affecting individuals worldwide. Current TB treatment strategy recommends the standard short-course chemotherapy regimen containing first-line drug, i.e., isoniazid, rifampicin, pyrazinamide, and ethambutol to treat pat…
Said BN, Heysell SK, Yimer G, Aarnoutse RE, Kibiki GS, et al.
…al discrimination in predicting treatment response for some regimens distinct from plasma exposure relative to MIC or mg/kg dose.
Bui VCB, Yaniv Z, Harris M, Yang F, Kantipudi K, et al.
Tuberculosis (TB) drug resistance is a worldwide public health problem. It decreases the likelihood of a positive outcome for the individual patient and increases the likelihood of disease spread. Therefore, early detection of TB drug resistance is crucial for improving outcomes …
Fatima S, Bhaskar A, Dwivedi VP
Tuberculosis (TB) is an infectious disease caused by an obligate intracellular pathogen, Mycobacterium tuberculosis (M.tb) and is responsible for the maximum number of deaths due to a single infectious agent. Current therapy for TB, Directly Observed Treatment Short-course (DOTS)…
Abdelwahab MT, Court R, Everitt D, Diacon AH, Dawson R, et al.
…d with absolute QTcF of >450 ms was 3.42% for all simulated regimens. The use of loading doses of 200 and 300 mg is not predicted to expose patients to an increased risk of QT prolongation, compared with the current standard treatment, and is, therefore, an alternative option for…
Gilmour B, Xu Z, Bai L, Alene KA, Clements ACA
…tematic management (AOR: 16.10 (14.49, 17.88) and treatment regimens that differed from full course management. Conclusions The increasing likelihood of an unsuccessful treatment outcome over time necessitates the need for further research.
Castro RAD, Ross A, Kamwela L, Reinhard M, Loiseau C, et al.
…quinolones (FQ) form the backbone in experimental treatment regimens against drug-susceptible tuberculosis. However, little is known on whether the genetic variation present in natural populations of Mycobacterium tuberculosis (Mtb) affects the evolution of FQ-resistance (FQ-R). …
Pettit AC, Shepherd BE, Sterling TR
…gh safety is unknown. Four-month fluoroquinolone-containing regimens are not recommended in the 2017 World Health Organization DS-TB treatment guidelines. These guidelines also recommend fixed-dose combination (FDC) therapy over single drug formulations based on patient preferenc…
Prajapati AC, Shah T, Panchal S, Joshi B, Shringarpure K, et al.
Background and aim The National Tuberculosis Elimination Program (NTEP) has been progressive in addressing the issues related to tuberculosis (TB) control in the country, with constant programmatic changes based on evidence available from operational research. Our objectives were…
Sahoo SK, Ommi O, Maddipatla S, Singh P, Ahmad MN, et al.
In our continued efforts to find potential chemotherapeutics active against drug-resistant (DR) Mycobacterium tuberculosis (Mtb), causative agent of Tuberculosis (TB) and to curb the current burdensome treatment regimen, herein we describe the synthesis and biological evaluation …
Zhang R, Pu J, Zhou J, Wang Q, Zhang T, et al.
…tern China, to provide evidence-based treatment and control regimens for DS-TB patients to improve adherence behaviours. Methods Both qualitative and quantitative research methods were used to explore the factors associated with self-reported adherence (SRA) behaviours. Questionn…
Masiphephethu MV, Sariko M, Walongo T, Maro A, Mduma D, et al.
…-susceptible tuberculosis (TB) and higher dose isoniazid in regimens for adults with drug-resistant TB, individual pharmacokinetic variability can lead to sub-target isoniazid exposure. Host pharmacogenetics and isoniazid exposure remain understudied, especially in the East Afric…
Wademan DT, Busakwe L, Nicholson TJ, van der Zalm M, Palmer M, et al.
SETTING: We conducted a qualitative exploration into the palatability and acceptability of a novel fixed-dose combination (FDC) anti-tuberculosis drug. This study was nested in the SHINE (Shorter treatment for minimal TB in children) trial, which compares the safety and efficacy …
Brooks MB, Malik A, Khan S, Ahmed JF, Siddiqui S, et al.
…tuberculosis (TB), despite availability of highly effective regimens. Few studies have evaluated predictors for poor treatment outcomes in children treated for TB. Methods We assessed predictors of unsuccessful TB treatment outcomes in a prospective cohort of children diagnosed b…
Grigoryan Z, McPherson R, Harutyunyan T, Truzyan N, Sahakyan S
Purpose Despite the availability of effective treatment, tuberculosis (TB) is still one of the leading causes of mortality around the globe. Poor adherence to treatment challenges TB management both globally and locally. Proper adherence to treatment contributes to successful out…