Showing 151–175 of 200 documents
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ASST Fatebenefratelli Sacco
…(hepatotoxicity) in adults treated for tuberculosis (TB) or latent tuberculosis infection (LTBI) and to understand which factors increase this risk. The study also aims to describe how hepatotoxicity is managed in real-world clinical practice and whether treatments such as cortic…
Stefania Cheli
…d prevent the occurrence of DILI and develop more effective treatments. Tuberculosis (TB) is the world's second leading cause of death from a single infectious agent in 2022, after COVID-19. In 2022, TB disease was estimated to affect 10.6 million people, of whom 1.3 million die…
Fröberg G, Jansson L, Nyberg K, Obasi B, Westling K, et al.
Swedish National tuberculosis (TB) guidelines recommend screening of active and latent TB (LTBI) among pregnant women (PW) from high-endemic countries or with previous exposure to possibly improve early detection and treatment.We evaluated cascade of care of a newly introduced TB…
Cheng Chen, Leonardo Martínez, Biao Xu
…d predict the risk of progress to TB disease in people with latent tuberculosis infection (LTBI). Recently, human genetic, immunological and metabolic biomarkers have been considered having promising prospects in monitoring and predicting TB risks qualitatively and quantitatively…
Steven M Holland, M.D.
…in actively recruiting individuals with TB for research and treatment studies. Objectives: \- To collect blood and other samples to study the natural history of tuberculosis. Eligibility: \- Individuals 2 years of age and older who have either active or latent tuberculosis. …
Fine S, Vecchio M, Filipe Goncalves Monteiro J, Vecchio E, Mao EJ
Background Biologic treatment for moderate to severe inflammatory bowel disease (IBD) places patients at risk for infectious complications. Tuberculosis (TB) infection and reactivation can lead to serious morbidity and mortality for immunosuppressed patients. As a result, guideli…
Phool Iqbal, Ashraf Tawfiq Soliman, Vincenzo Desanctis, Mohamed A. Yassin
…e. Tyrosine kinase inhibitors (TKI) are the mainstay of the treatment to achieve remission, while bone marrow transplant is the only proven cure. Tuberculosis (TB), both active and reactivation of latent TB, remains the most common infectious disease worldwide and leads to high m…
Jyoti S. Mathad, Sylvia M. LaCourse, Amita Gupta
…ganization (WHO) recommends improving access to testing and treatment of latent TB infection (LTBI) [1]. Despite recent epidemiologic studies demonstrating an approximately twofold increased risk of active TB in peripartum women [2], and poor outcomes associated with TB during pr…
Bhumika Harishkumar Bhavsar, Vipul D. Prajapati, Dhaiwat Shukla, Supriya Malhotra
… for autoimmune diseases, raises concern about reactivating latent tuberculosis (TB) and new-onset TB. Despite its established efficacy in managing inflammation, clinicians must recognize and manage adalimumab-induced TB promptly to minimize associated morbidity. This case report…
Nisha Yadav, Sushant Satish Mane, Jyothi Janardhanan, Manas Pustake, Gazi Israil Khan, et al.
of hospital stay in COVID-19 patients with TB, and treatment of COVID-19 in TB. Materials a n d Methods Study DesignA retrospective observational study was done at a tertiary care hospital in Mumbai, India.Children with TB and those without TB were enrolled in the study.According…
Mariana Baptista Angeluci, Marilda Aparecida Milanêz Morgado de Abreu, Ana Cláudia Cavalcante Espósito, Eduardo Vinícius Mendes Roncada, Cristhiana Kise Saito, et al.
…ts and, consequently, increases the risk of reactivation of latent infections, such as tuberculosis (TB). 2 Recent guidelines recommend carrying out TB screening before starting treatment with any immunobiological agent, using the tuberculin skin test (TST) or interferon gama rel…
Dibash Kumar Das
…checkpoint inhibitors (ICIs) have been revolutionary in the treatment of various cancer types, demonstrating favorable outcomes and having been generally well-tolerated by patients with cancer compared to cytotoxic therapy (Front Oncol 2021; doi: 10.3389/fonc.2021.625872). ICIs e…
Jorge Cardenas, Maria E. Campos-Bonaguro, Jacques Simkins
…than 80% of active TB cases arise from previously untreated latent tuberculosis infection (LTBI),3 hence preventive strategies are paramount. In light of the significant burden that TB may inflict in this population, routine screening for LTBI in liver transplant candidates (LTCs…
Andrea A Howard, MD
…, transferred out); TB (tuberculosis) screening results; TB treatment (yes/no); TB treatment outcomes (if applicable); and retention in HIV care. A measurement cohort of 500 HIV-infected patients initiating IPT on or after July 1, 2013 will be recruited from the 10 clinics (n=25…
Gavin Churchyard, MBBCh, PhD
…n most high burden tuberculosis (TB) countries. In its 2015 guidelines, WHO includes 3HP as an latent tuberculosis infection (LTBI) treatment option for high-income and upper middle-income countries with TB incidence rates \<100/100,000. One trial comparing 3HP to 6H in a high bu…
Siva Prasad Korikana, Sreenivasa Rao Battula, Naresh Konduru, Aravind Kurnool, Divya Kumar Vemuri, et al.
…pentine, an essential therapeutic agent for both active and latent tuberculosis (TB). The chromatographic separation was achieved on a YMC Pack C18 column (250 × 4.6 mm, 5 μm) using a gradient elution with Solvent A composed of phosphate buf…
Trevor Hansel, FRCPath, PhD, Peter JM Openshaw, FRCP, PhD, FRSB, FMedSci, Robin Shattock, PhD
…will be managed as per GCP and local Information Governance guidelines. NUMBER OF SUBJECTS AND DOSING PART 1: Nasal ascending dose challenge with microbial constituents using MPLA, polyIC, polyICLC and resiquimod. This is divided into part A and part B. PART 1A (n=32): Increme…
Vadakkan Devassy T, K V S, Jacob A, Meleppat VM
…icating clinical status of paediatric oncology patients and treatment of infection with this bacilli is challenging in this subpopulation of patients because of ongoing immunosuppression and relative lack of published guidelines. Atypical presentations of tuberculosis in children…
Xi Wang, Shengfei Hu, Rui Hong, Xi Cheng, Ye Hong, et al.
…ptica spectrum disorder (NMOSD). Currently, no standardized guidelines exist for preventing hepatitis B reactivation (HBVr) or tuberculosis reactivation (TBr) during the use of B cell-depleting agents in patients with NMOSD who are at risk of HBVr or TBr. Furthermore, data on HBV…
Mariano Victor, Andrade Laíla, Oliveira Fernanda, Santos Monique, Pereira Martins Fernanda, et al.
…e, potent immunosuppressive therapy has become the standard treatment for inflammatory bowel disease (IBD) (1). However, the increasingly use of immunomodulators associated to biological therapy—especially the inhibitors of tumor necrosis factor alpha (TNF-α)—have considerably in…
Gèrard de Vries, Jossy van den Boogaard, Ibrahim Abubakar
…ation was unchanged in the 2021 update [[3]WHO consolidated guidelines on tuberculosisModule 2: screening - systematic screening for tuberculosis disease. World Health Organization, Geneva2021Google Scholar]. The specific details of the combination of tools to use in such screeni…
Sashi N Nair, Indira Brar, Gireeshkumar K.P.
…cribed in HIV infected patients. Developed countries, where guidelines on the treatment of PJP have been created have dramatically lower rates of latent and active TB than developing countries. PJP may obscure the diagnosis or delay the treatment of TB. Furthermore, treatment of …
Nair S, Brar I, K.P. G
…cribed in HIV infected patients. Developed countries, where guidelines on the treatment of PJP have been created have dramatically lower rates of latent and active TB than developing countries. PJP may obscure the diagnosis or delay the treatment of TB. Furthermore, treatment of …
Cheon J, Kim C, Park EJ, Ock M, Lee H, et al.
…culosis (TB) develops in approximately 10% of people with a latent tuberculosis infection (LTBI). TB guidelines recommend that LTBI screening and treatments target high-risk patients. Malignancies are not universally considered a high-risk factor for active TB. This study aimed t…
Sarah van de Berg, Andreas Beyerlein, Johannes Stephani, Beatrix Bäumler-Merl, Manuela Jäger, et al.
…ield of TB contact investigations, compliance with national guidelines and risk factors for infection among contacts.METHODSWe analysed anonymised data of TB patients and their contacts collected between 2018 and 2022 in Upper Bavaria, Germany. We assessed testing coverage, laten…