Showing 151–175 of 200 documents
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Meddy Setiawan, Raditya Widya Surianata, Yolla Gitamaya Yustikasari, Ridho A'bid Permana, Nurani Hakiki, et al.
…ofile of TB cases that are resistant to antibiotics and the resistance pattern of Mycobacterium tuberculosis in patients at Haji Regional Hospital, East Java Province Method: The type of research is descriptive-retrospective based on primary data from patient medical records and …
Loiseau C, Windels EM, Gygli SM, Jugheli L, Maghradze N, et al.
Multidrug-resistant tuberculosis (MDR-TB) is among the most frequent causes of death due to antimicrobial resistance. Although only 3% of global TB cases are MDR, geographical hotspots with up to 40% of MDR-TB have been observed in countries of the former Soviet Union. While the …
Naidoo K, Dookie N
Early diagnosis, including universal drug-susceptibility testing for all patients with tuberculosis, remains a key priority for tuberculosis elimination by 2035. The drug-resistant tuberculosis care cascade remains persistently challenged by substantial gaps in timely diagnosis a…
Loan Duong, Khang Tan, Dung Nhan Tran, Phuc Huu Lu, Thang Nguyen
…is (TB) has been a threat to world health for decades. Multidrug-resistant TB (MDR-TB) is adding to the burden of disease and hindering the development of countries. This study aimed to identify the drug-resistant rate in patients with recurrent pulmonary TB and detect rifampicin…
Ojetayo Helen Oluwatosin, Daniel Ugbomioko
…o investigate the association between cytokines and anti-TB drug resistances. A total of 217 people living with human immunodeficiency virus at University College Hospital, Ibadan were recruited. Venous blood and sputum samples were collected. Sputum samples were cultured for Myc…
WHO Global Tuberculosis Programme, WHO/IUATLD Global Project on Anti-Tuberculosis Drug Resistance Surveillance
Park S, Jung J, Kim J, Han SB, Ryoo S
…ne (CFZ) showed a good therapeutic effect in treating multi-drug-resistant tuberculosis (MDR-TB), the anti-tuberculosis activity and resistance were re-focused. Here, we investigated the CFZ resistance and genetic mutations of drug-resistant Mycobacterium tuberculosis (DR-Mtb) is…
Billows N, Phelan J, Xia D, Peng Y, Clark TG, et al.
…impact on global health worldwide. The development of multi-drug resistant strains that are resistant to the first-line drugs isoniazid and rifampicin threatens public health security. Rifampicin and isoniazid resistance are largely underpinned by mutations in rpoB and katG respe…
Chen S, Liu H, Li T, Lai W, Liu L, et al.
… The currently used conventional susceptibility testing for drug-resistant Mycobacterium tuberculosis (M.TB) is limited due to being time-consuming and having low efficiency. Herein, we propose the use of a microfluidic-based method to rapidly detect drug-resistant gene mutations…
Sampath P, Natarajan AP, Moideen K, Kathamuthu GR, Hissar S, et al.
The rampant increase in drug-resistant tuberculosis (TB) remains a major challenge not only for treatment management but also for diagnosis, as well as drug design and development. Drug-resistant mycobacteria affect the quality of life owing to the delayed diagnosis and require p…
Xu Wei, Xiuzhi Zhang, Aijie Zhang, Wei Yunfang
Objective To supply evidence with prevention and control of drug-resistant tuberculosis in school, through investigation and analysis of the epidemic cluster of drug-resistant tuberculosis in a school of Chaoyang District, Beijing. Methods The cases were investigated of epidemiol…
Rubeshan Perumal, Neda Bionghi, Camus Nimmo, Marothi Letsoalo, Matthew J. Cummings, et al.
…ationale Bedaquiline is a novel antimycobacterial agent for drug-resistant tuberculosis (DR-TB) and is classified as a World Health Organization (WHO) Group A drug due to its excellent clinical efficacy, high bactericidal activity, and potent sterilizing effect. Baseline and trea…
Bhattacharyya K, Nemaysh V, Joon M, Pratap R, Varma-Basil M, et al.
…nce the expression of embAB, which correlates with the high resistance of the VPCI591 to ethambutol. Similarly, the unique combination of three genic SNVs in RNA polymerase β gene (rpoB) in VPCI591 was evaluated for its effect on rifampicin resistance through molecular docking an…
Singh A, Sharma D, Gopinath K, Gupta AK, Sharma P, et al.
…tuberculosis (M. tuberculosis) from a patient who developed drugresistant tuberculosis (TB) in vivo during anti-tuberculosis therapy (ATT). Introduction Various studies have found the Beijing lineage of M. tuberculosis strongly associated with multidrug resistance (MDR) developme…
Ejaz Shaikh, Umair Shaikh, Farha Ansari, Rehan Safee
…d other tissues of the body are also affected. TB caused by drug-susceptible strains is curable in virtually all the cases after proper treatment. The untreated TB may be fatal within 5 years in 50%–65% of the cases. Drug-resistant TB is a worldwide threat. Treatment of drug-resi…
De Almeida Crispim J, Arroyo LH, Zamboni Berra T, Lima Dos Santos F, Limirio Souza LL, et al.
Introduction Prisons are high-risk settings for drug-resistant tuberculosis because the prevalence of the tuberculosis (TB) is much higher than in the general population. This study to investigated the factors associated with drug-resistant tuberculosis in prisons in the state of…
Robert Msokwa, Callistar Smoke, Loreen Saidi
BACKGROUND. Multi Drug Resistant Tuberculosis poses a great challenge to TB control in Malawi as well as worldwide. Most cases of TB are concentrated in cities in Malawi. OBJECTIVE. To explore clinicians’ experiences of accessing drug-resistant tuberculosis susceptibility testing…
Madrazo-Moya CF, Cancino-Muñoz I, Cuevas-Córdoba B, González-Covarrubias V, Barbosa-Amezcua M, et al.
…sequencing (WGS) has been proposed as a tool for diagnosing drug resistance in tuberculosis. However, reports of its effectiveness in endemic countries with important numbers of drug resistance are scarce. The goal of this study was to evaluate the effectiveness of this procedure…
Bakuła Z, Modrzejewska M, Pennings L, Proboszcz M, Safianowska A, et al.
Very few studies have examined drug susceptibility of Mycobacterium kansasii , and they involve a limited number of strains. The purpose of this study was to determine drug susceptibility profiles of M. kansasii isolates representing a spectrum of species genotypes (subtypes) wit…
Hou K, Jabeen R, Sun L, Wei J
A steady increase in the prevalence of drug-resistant tuberculosis (DR-TB) has already been reported in Pakistan. In addition, DR-TB is gradually changing from one-drug resistance to multi-drug resistance, which is a serious challenge for tuberculosis treatment. This review provi…
Wang L, Chen B, Zhou H, Mathema B, Chen L, et al.
Understanding the emergence and evolution of drug resistance can inform public health intervention to combat tuberculosis (TB). In this prospective molecular epidemiological surveillance study from 2015 to 2021 in eastern China, we prospectively collected whole-genome sequencing …
Sümeyya Çapuk, Gülnur Tarhan
Introduction: Multi-drug resistant tuberculosis (MDR-TB) is still an important public health problem.Rapid agent diagnosis and resistance status determination are critical in establishing the correct treatment protocol.This study was conducted to determine resistance mutations ag…
WHO/IUATLD Global Project on Anti-Tuberculosis Drug Resistance Surveillance
WHO/IUATLD Global Project on Anti-Tuberculosis Drug Resistance Surveillance, World Health Organization, World Health Organization
Abad CLR, Razonable RR
Background Management of multidrug-resistant (MDR) and rifampin-resistant (RR) tuberculosis is challenging. Data on transplant recipients is limited. We reviewed published literature to examine treatment choices, outcomes, and adverse effects from MDR-TB/RR-TB treatment in transp…