Showing 151–175 of 200 documents
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Esther Uwimaana
…Network of Tuberculosis (COHSONET) study and the Kampala TB Drug Resistance Survey (KDRS). Methods: A total of 210 participants were enrolled in a study of a diagnostic method aimed at determining the levels of HO-1 and neopterin, and determine their diagnostic accuracy as biomar…
A.H. Jokhio, Simon Bell, Mohammad Wasay, Arshad Majid
…kistan ranks 5th among 30 high-burden countries and 5th for Drug Resistant TB (DRTB). The incidence of TB in Pakistan is 267 per 100,000 (1) with an estimated 525,000 cases in 2017 including 57,000 cases among those who were less than 15 years of age.
Niño-Padilla EI, Velazquez C, Garibay-Escobar A
…can form biofilms and contribute to latent tuberculosis and drug resistance because of the long-lasting and recalcitrant nature of its infections. This review discusses some of the molecular mechanisms by which biofilms could play a role in infection or pathological events in hum…
He J, Song L, Zheng P
…10]). In addition, the infection status, TB focus location, drug resistance, race, research design type, and detection method divided the subjects into different subgroups for the meta-analysis. The results of the comparison of healthy controls and TB subjects showed that in the …
Medrano BA, Lee M, Gemeinhardt G, Yamba L, Restrepo BI
…less lung cavitations) in OA. During treatment, OA had less drug-resistant TB, few adverse reactions and adhered with TB treatment. We recommend training healthcare workers to 'think TB' in OA, for prompt treatment initiation to diminish deaths. Furthermore, OA should be added as…
Medrano BA, Lee M, Gemeinhardt G, Rodríguez-Herrera JE, García-Viveros M, et al.
…a-pulmonary TB and less likely to abandon treatment or have drug resistant TB), and yet, were more likely to die during TB treatment (adj-OR 3.9, 95% 2.5, 5.25). Among the OA, excess alcohol use and low body mass index increased their odds of death during TB treatment, while a hi…
Wells C, Severn M
… and can lead to poorer patient outcomes and development of drug-resistant TB. The intensive nature of treatment can lead to significant barriers for people attending treatment, especially those in hard-to-reach populations or those who are poorer and cannot afford to take time o…
Nikitushkin V, Shleeva M, Loginov D, Dyčka F F, Sterba J, et al.
…, in addition to low metabolic activity and a high level of drug resistance, are characterized by 'non-culturability'-a specific reversible state of the inability of the cells to grow on solid media. The biochemical characterization of this physiological state of the pathogen is …
Yadav D, Kaur S, Banerjee D, Bhattacharyya R
…a highly infectious disease intensified by the emergence of drug-resistant strains. In tuberculosis disease spectrum, a typical situation is a dormant or latent phase where a person exposed to Mycobacterium tuberculosis has the reservoir of the disease that may or may not result …
Mouton JM, Heunis T, Dippenaar A, Gallant JL, Kleynhans L, et al.
…ities. Auxotrophic strains have been assessed as models for drug-resistant M. tuberculosis and for studying latent TB. These offer the potential as safe and useful models, but it is important to understand how well these recapitulate salient features of non-attenuated M. tubercul…
La Manna MP, Shekarkar-Azgomi M, Badami GD, Tamburini B, Dieli C, et al.
…ensitive diagnostic approaches, as well as the emergence of drug-resistant forms of M. tuberculosis . Cellular immunity has a pivotal role against M. tuberculosis infection, but the role of humoral immunity is still controversial. We analyzed the frequency, absolute counts, and p…
Sadiya Ramli, Nihayatul Karimah, Astutiati Nurhasanah, Najdah Hidayah, Muhammad Nasrum Massi, et al.
…However, genetic variations may influence pathogenicity and drug resistance. This study investigates mutations in the Rv2660c gene and their potential impact on protein structure and function. **MATERIALS AND METHODS:** The Rv2660c gene from 40 clinical isolates was analysed usi…
Gordhan BG, Peters J, Kana BD
…synergy between TB-HIV infection and the rapid emergence of drug resistant strains has created a global public health threat that requires urgent attention. Mycobacterium tuberculosis, the causative agent of TB is an exquisitely well-adapted human pathogen, displaying the ability…
Assistance Publique - Hôpitaux de Paris
…ngoing transmission of the infection and the development of drug resistance. Therefore, surveillance of TB treatment outcomes is also of great importance when evaluating TB programs. Since 2014, the target set by WHO is 90% of treatment success among new sputum smear-positive TB …
Eduarda Rabello, Fernanda de-Paris
…rbated by HIV co-infection and the increasing prevalence of drug-resistant strains. Although a wide range of laboratory diagnostic methods are currently available, their applicability, implementation, and clinical impact vary substantially across healthcare settings with differen…
Sethi G, Varghese RP, Lakra AK, Nayak SS, Krishna R, et al.
…y rate than other bacterial diseases, and the rapid rise of drug-resistant strains only makes the situation more concerning. Currently, the only licensed vaccine BCG (Bacillus Calmette-Guérin) is ineffective in preventing adult pulmonary tuberculosis prophylaxis and latent tuberc…
Fengjiao Wu, Ru Huang, Yuxuan Lin, Xixi Zhu, Yujie Li, et al.
…TB), caused by(MTB), remains a major global health problem. Drug resistance and the limitations of sputum-based diagnostic methods highlight the need for additional host-response biomarkers. Protein tyrosine phosphatase receptor type O (PTPRO) has been implicated in inflammatory …
Prestileo T, Pipitone G, Sanfilippo A, Ficalora A, Natoli G, et al.
…B, and 59 had pulmonary TB (38 sputum smear positive TB; no drug-resistant TB were observed). Conclusions TB screening is critical to early diagnosis and treatment.
Harries AD, Lin Y, Kumar AMV, Satyanarayana S, Takarinda KC, et al.
…r effective infection control practices; diagnose and treat drug-resistant TB, associated HIV infection, and diabetes mellitus; design and implement active case finding strategies for high-risk groups and link them to the treatment of latent TB infection; engage with the private-…
Riya Mishra, Rahul Pal, Raj Kumar Mandal
… such as GeneXpert have facilitated the detection of TB and drug resistance promptly. Other challenges like high cost, need for infrastructure and heterogeneity of performance persist. New diagnostic technologies are transforming TB detection into a faster, more preciseand less e…
C. R. Saju
…ave active TB using standardized regimens and follow-up for drug resistance. To prevent the spread of the illness, treating people with active TB should be the top priority for TB control. However, identifying and treating those with latent TB should also be a top priority. Preve…
Songuigama Coulibaly, Jean-Paul Déto Ursul N'Guessan, Jean-Fabrice K. Koffi, Soro T. Grâce, Mahama Ouattara
…sis (TB) faces several challenges, such as the emergence of drug-resistant TB, long treatment duration, management of latent TB, and toxic adverse effects leading to non-compliance with treatment. To address this, WHO encourages the search for new molecules that are more effectiv…
Biswajit Chakraborty, Amaj Laskar, Anamika Baruah, Remesh Kumar, Mustafa A. Barbhuiya
…on early detection, management of latent TB, and control of drug resistance are critical. This review explores global guidelines, highlights implementation challenges, and suggests pathways for achieving effective TB control in India.
Giggil Pushpamithran
…ections. Treating TB is challenging due to the emergence of drug-resistant strains, the lengthy treatment duration, significant side effects, and complications arising from coinfections like HIV and helminths. Helminths, known to induce a Th2-biased immune response, may influence…
Ankur Gupta, Garhima Arora, Nandadulal Bairagi, Samrat Chatterjee
…ed the impact of these proposed treatment strategies on the drug‐resistant population in high‐incidence scenarios. The model predictions suggested molding the current treatment strategies and focused implementation of LTBI diagnosis and treatment in high‐incidence scenarios.