Showing 151–175 of 200 documents
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Zh. T. Zhandauletova, Е. И. Никишова, А. O. Мaryandyshev, K. S. Serikbaeva, M. M. Adenov, et al.
…nd compliance with new regimens for preventive treatment of drug susceptible and drug resistant tuberculosis. Subjects and Methods . The study was carried out in Almaty, the Republic of Kazakhstan; 182 patients from the groups facing the high risk of developing active tuberculosi…
Heda Melinda Nataprawira, Intan M W Dewi, I Gusti Agung Ayu Novi Wiraningrat, Citra Cesilia
…of the literature on the differences in imaging findings in drug-resistant (DR) and drug-sensitive tuberculosis (DS TB) children and adolescent TB survivors. **METHOD:** We performed a systematic review to determine imaging patterns of DR and DS TB in children and adolescent sur…
Garcia-Contreras L, Hanif SNM, Ibrahim M, Durham P, Hickey AJ
CPZEN-45 is a novel compound with activity against drug-susceptible and drug-resistant tuberculosis (TB). The present study was undertaken to determine the best dose and dosing regimen of inhalable CPZEN-45 powders to use in efficacy studies with TB-infected guinea pigs. The disp…
Shumaila Nida Muhammad Hanif, Phillip G. Durham, Mariam Ibrahim, Lucila Garcia‐Contreras, Anthony J. Hickey
CPZEN-45 is a novel compound with activity against drug-susceptible and drug-resistant tuberculosis (TB). The present study was undertaken to determine the best dose and dosing regimen of inhalable CPZEN-45 powders to use in efficacy studies with TB-infected guinea pigs. The disp…
Chihota V, Gombe M, Gupta A, Salazar-Austin N, Ryckman T, et al.
…ment (TPT) regimens are available for all ages and for both drug-susceptible and drug-resistant TB infection. All regimens are generally safe, efficacious, and cost effective and have a low risk of generating resistance. TPT is recommended for pregnant women who are at risk for d…
Seo H, Al Mahmud H, Kim S, Islam MI, Lee KI, et al.
…FC-2 was confirmed to show anti-tubercular activity against drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis. To support the safety-in-use of DFC-2 as an anti-tubercular drug, DFC-2 was tested via single- and 28-day repeated-dose oral toxicity study and m…
Campaniço A, Harjivan SG, Freitas E, Serafini M, Gaspar MM, et al.
…gainst M. tuberculosis H37Rv, as well as equipotent against drug-susceptible and drug-resistant M. tuberculosis isolates. The new N-carbamoyl azaaurones exhibited improved microsomal stability, compared to their N-acetylated counterparts, with several compounds displaying moderat…
Tanner L, Evans JC, Seldon R, Jordaan A, Warner DF, et al.
…globally, demanding the urgent development of faster-acting drugs with novel mechanisms of action. Riminophenazines such as clofazimine are clinically efficacious against both drug-susceptible and drug-resistant strains of M. tuberculosis We determined the in vitro anti- M. tuber…
Linh Nguyen, Kerri Viney, Medea Gegia, Dennis Falzon, Philippe Glaziou, et al.
…rmly applicable for different lengths of treatment for both drug-susceptible and drug-resistant disease</b>https://bit.ly/3jFFgOu
Borsoi AF, Paz JD, Pissinate K, Rambo RS, Pestana VZ, et al.
…ported the design and synthesis of quinoline derivatives as drug candidates for the treatment of TB. These compounds have demonstrated potent and selective growth inhibition of drug-susceptible and drug-resistant Mtb strains. Herein, a new synthetic approach was established provi…
Kranti Garg
…ted burden of the psychological comorbidity associated with drug-resistant TB (DRTB) and drug-sensitive TB (DSTB) is controversial. It is expected to be higher in patients with DRTB than patients with DSTB due to previous multiple regimens of drugs, treatment failures, pill burde…
Christian Noel Dide-Agossou
New shorter treatment regimens for both drug-susceptible and drug-resistant tuberculosis (TB) are urgently needed. The key roadblock in TB regimen development is lack of valid surrogate pharmacodynamic markers for TB relapse. A recently-proposed assay called the ribosomal RNA (rR…
Christian Noel Dide-Agossou
New shorter treatment regimens for both drug-susceptible and drug-resistant tuberculosis (TB) are urgently needed. The key roadblock in TB regimen development is lack of valid surrogate pharmacodynamic markers for TB relapse. A recently-proposed assay called the ribosomal RNA (rR…
Lombardi A, Pappas F, Nedelman J, Hickman D, Jaw-Tsai S, et al.
…with bedaquiline, is under development for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). A phase 1, first-in-human study of TBAJ-876, comprising a single-ascending dose (SAD) part including a food effect cohort, a multiple-ascending dose (MAD) part, and …
World Health Organization. Regional Office for Europe
…on (WHO) recommends that standard treatment for TB, whether drug-susceptible or drug-resistant, should be given as ambulatory care, with patients remaining within their community and continuing with normal life in so far as they feel well enough. Hospitalization need occur only i…
Li P, Wang B, Zhang X, Batt SM, Besra GS, et al.
…compound 6b exhibited potent in vitro activity against both drug-susceptible and drug-resistant tuberculosis clinical strains with MICs <0.016 μg/mL. In addition, compound 6b demonstrated excellent ADME/T and PK properties and potent in vivo efficacy with bactericidal activity in…
Zhang W, Lun S, Wang SS, Cai YP, Yang F, et al.
…an 32 showed excellent antitubercular activity against both drug-susceptible and drug-resistant Mtb strains (MIC = 0.0039-0.0078 μg/mL) and exhibited limited hERG inhibition (IC 50 ≥ 25 μM). Moreover, 32 exhibited improved metabolic stability relative to parent compound 8 while s…
Benito P, Vashakidze S, Gogishvili S, Nikolaishvili K, Despuig A, et al.
…icant for the following groups: women, age -2 , nonsmokers, drug-susceptible and drug-resistant participants, both new and relapsed patients, early culture negativisation, cases with a single lesion, either lesions <35 mm or ≥35 mm, and lesion, lobe and lung resections. The analy…
Kusmiati T, Burhan E, Sugiyono RI, Arlinda D, Naysilla AM, et al.
…ent microbiological TB examinations and were categorized as drug-sensitive (DS), drug-resistant (DR), and clinically-diagnosed TB. Anti-H. capsulatum IgG antibody levels at baseline were measured using MVista Histoplasma Ab enzyme immunoassays. Data were summarized using descript…
Jittimanee S, Namonta A, Charuenporn C
…ategory 5 and 22.2% using TB-P1. Treatment success rates in drug-susceptible and drug-resistant TB patients were respectively 66.7% and 33.3%. CONCLUSION: The WHO radiograph categorisation could be used to screen for TB in the field and may be applied in artificial intelligence f…
Abdulrhman Awadh Alharbi, Ibrahim Muhammad Al-Arej, Abdullatif Suliman Alsayegh, Meshal Ibrahim Zaid Al Owias, Bader Sayah Alanezi
…s diagnostic and treatment protocols are discussed for both drug-susceptible and drug-resistant TB strains. Results: TB diagnosis relies on a combination of imaging, microbiologic testing, and immune-based tests. While AFB smears and NAATs remain primary diagnostic methods, novel…
Finlayson H, Lishman J, Palmer M
…tment as well as shorter regimens for the treatment of both drug-susceptible and drug-resistant TB. The Xpert Ultra assay is now recommended as the initial diagnostic test for TB in children with presumed TB and can also be used on stool samples. Point-of-care urinary lipoarabino…
Yasobant S, Shah H, Bhavsar P, Patel J, Saha S, et al.
…he study targeted a diverse profile of TB patients, such as drug-sensitive TB (DSTB), drug resistance TB (DRTB), pediatric TB, and extra-pulmonary TB. It included both public and private sector patients. The study findings suggested that about 41% of pulmonary and 51% of extra-pu…
Aner H Khan
…duration of current treatment regimens, especially for both drug-susceptible and drug-resistant TB. There is a need for continuing the quest for low-cost, reliable, and acceptable measures of adherence for the treatment of TB and HIV co-infection. A qualitative approach and pharm…
Tshwanelo B Matlala, Phelelisiwe S Dube, Audrey Jordaan, Lesetja J Legoabe, Digby F Warner, et al.
…nd pretomanid) have been approved for the treatment of both drug-susceptible and drug-resistant forms of tuberculosis. Besides toxicity reported for these compounds, they are chiral molecules which must be separated into pure forms; thus reducing synthetic accessibility. Herein, …