Showing 151–175 of 200 documents
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Eoh H, Liu R, Lim J, Lee JJ, Sell P
…r non-replicating and lacking a stably heritable antibiotic resistance, termed drug tolerance). The formation of drug-tolerant Mtb persisters is associated with TB treatment failure and is thought to be an adaptive strategy for eventual development of permanent genetic mutation-m…
Utpat KV, Rajpurohit R, Desai U
Background Drug-resistant tuberculosis (DR-TB) is the most exigent and calamitous challenge encountered in treatment of TB. Extra pulmonary (EP) DR-TB poses a complex diagnostic and therapeutic challenge owing to myriad of presentations and paucibacillary nature. Data available o…
Robin Varughese John, Hafiz Deshmukh, Sunil Jadhav, Ashish Deshmukh, Shivprasad Kasat, et al.
OBJECTIVE: To study the sensitivity and resistance pattern of multi-drug resistant tuberculosis patients at a tertiary care centre. METHODS: Retrospective study will be conducted at tertiary care centre in Aurangabad from which data of patients will be collected who have register…
Tao NN, Li YF, Song WM, Liu JY, Zhang QY, et al.
…ve This study was designed to identify the risk factors for drug-resistant tuberculosis (DR-TB) and the association between comorbidity and drug resistance among retreated pulmonary tuberculosis (PTB). Design A retrospective study was conducted among all the 36 monitoring sites i…
Singh V, Chibale K, Chibale K
" Drug resistance is an unavoidable consequence of the use of drugs; however, the emergence of multi-drug resistance can be managed by accurate diagnosis and tailor-made regimens. "Antimicrobial resistance (AMR), is one of the most paramount health perils that has emerged in the …
Aarav Sinha, Jothsna Kethar, Dr.Rajagopal Appavu
Drug-resistant tuberculosis (TB) poses a significant global health challenge, affecting millions worldwide. Annually, around half a million individuals develop drug-resistant TB, underscoring the urgency of addressing this issue. Treating drug-resistant TB is complex and lengthy,…
Jiandong Yang, Pengwei Lou, Weisheng Zhang, Yanggui Chen, Yaoqin Lu, et al.
…ate the epidemic status and distribution characteristics of drug-resistantin Urumqi. From January 2019 to July 2024, all sputum culture-positivestrains were collected in Urumqi. Using the traditional solid-state proportion method for drug-sensitivity testing, we determined the re…
Desai U, Joshi JM
Background Drug-resistant tuberculosis (DR-TB) is a global problem with only 52% reported cure rate. Extrapulmonary (EP) DR-TB poses a formidable diagnostic, therapeutic challenge. We aimed to study their clinical profile and treatment outcomes under the programmatic setting. Mat…
V Bajiya, C R Choudhary, G Purohit, A Kuwal, A Mohanty
<b>Background:</b> Drug resistant tuberculosis is a serious public health problem in India. Due to inappropriate use, resistance to FQs has increased, which is a major threat to control TB worldwide. FQ resistance is caused by mutation in gyrA and gyrB genes of Mycobacterium tube…
Anil Regmi, Bishwa Bandhu Niraula, Abdus Sami, Vijay Kumar Jain, Gayatri Vishwakarma, et al.
Multidrug-resistant (MDR), pre-extensively drug-resistant (pre-XDR), and extensively drug-resistant (XDR) strains are associated with delayed diagnosis, protracted therapy, and increased morbidity. This article aims to systematically review the clinical spectrum, diagnostic strat…
Rêgo AM, Alves da Silva D, Ferreira NV, de Pina LC, Evaristo JAM, et al.
…ading cause of death. Mycobacterium tuberculosis antibiotic resistance is becoming increasingly common and disease control is challenging. Conventional drug susceptibility testing takes weeks to produce results, and treatment is often initiated empirically. Therefore, new methods…
Wang G, Jiang G, Jing W, Zong Z, Yu X, et al.
The drug resistance prevalence data facilitates selection of the initial drug for treating multidrug-resistant tuberculosis (MDR-TB). The aim of this study was to investigate the prevalence and molecular characterization of seven additional types of drug resistances among MDR-TB …
Noorizhab MNF, Zainal Abidin N, Teh LK, Tang TH, Onyejepu N, et al.
Multidrug-resistant (MDR) or extensively drug-resistant (XDR) Tuberculosis (TB) is a major challenge to global TB control. Therefore, accurate tracing of in-country MDR-TB transmission are crucial for the development of optimal TB management strategies. This study aimed to invest…
Shraddha Dalvi, Poulami Biswas, Shatabdi Bhagat, Nilma Hirani
…ng cause of death from a single infectious agent worldwide. Drug-resistant TB (DR-TB) poses a major challenge. Bedaquiline (BDQ) is central to multidrug resistant tuberculosis/extensively drug-resistant TB (MDR/XDR-TB) treatment, yet emerging resistance prompted this study to ass…
Jalil Kardan-Yamchi, Hossein Kazemian, Arash Ghodousi, Daniela María Cirillo, Masoumeh Douraghi, et al.
Aims and objectives: Treatment of patients with drug-resistant tuberculosis is time-consuming and requires expensive drugs with more toxicity. Proper and timely identification of drug-resistant genotypes and determining the minimum inhibitory concentrations (MICs) alongside with …
Miiro E, Olum R, Baluku JB
Background Drug-resistant tuberculosis (DR-TB) is a threat to tuberculosis (TB) control. Extra-pulmonary forms of DR-TB (DR-epTB) are not well characterized. This review summarizes the clinical features, resistance patterns and treatment outcomes of DR-epTB. Methods We searched E…
Okumu A, Orwa J, Sitati R, Omondi I, Odhiambo B, et al.
Multidrug-resistant tuberculosis (MDR-TB) is caused by M. tuberculosis ( Mtb ) with resistance to the first-line anti-TB medicines isoniazid (INH) and rifampicin (RIF). In Western Kenya, there is reported low prevalence of drug resistant strains among HIV tuberculosis patients, c…
Katran ZY, Bulut İ, Babalık A, Keren M, Tepetam FM, et al.
Objective To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods This was a retrospective study. The primary aim of the study is to determine the demographic and clinical characteristics of patients who develop drug …
Wang Z, Sun R, Mu C, Wang C, Zhao H, et al.
…cular characteristics of fluoroquinolone-resistant and multidrug-resistant M. tuberculosis strains using whole-genome sequencing to predict drug resistance in M. tuberculosis in Tianjin, China, which has not been established previously. Methods Twenty-one fluoroquinolone-resistan…
Li Q, Zhao G, Wu L, Lu M, Liu W, et al.
Background To evaluate prevalence and patterns of drug resistance among pulmonary tuberculosis (TB) patients in Hangzhou City, China. Methods Sputum samples of smear positive TB patients enrolled in 2011 and 2015 were collected and tested for drug susceptibility, and demographic …
Rana HK, Singh AK, Kumar R, Pandey AK
…culosis (TB). TB control programmes are facing threats from drug resistance. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb strains need longer and more expensive treatment with many medications resulting in more adverse effects and decreased chances of treatm…
Hameed S, Ahmad SR, Rahman MAU, Nazir H, Ullah I
Objectives Drug-resistant tuberculosis (DR-TB) is a major challenge to national TB control programmes in developing countries. In the Pakistan province of Punjab, the extent and development of DR-TB is not well known. The current study was therefore conducted to assess the incide…
Tawsifur Rahman, Amith Khandakar, Ashiqur Rahman, Susu M. Zughaier, Muna Al Maslamani, et al.
… and expensive treatments. Moreover, due to the increase of drug-resistant tuberculosis, the disease becomes more challenging in recent years. In this work, a novel deep learning-based framework is proposed to reliably and automatically distinguish TB, non-TB (other lung infectio…
Pan Y, Yu Y, Lu J, Yi Y, Dou X, et al.
Purpose The emergence of drug-resistant tuberculosis (DR-TB) represents a threat to the control of tuberculosis. This study aimed to estimate the patterns and trends of DR-TB in patients with suspected DR-TB. In addition, risk factors for multidrug-resistant tuberculosis (MDR-TB)…
Lies Dina Liastuti, Kelvin Kohar, Haifa Mayang Lestari, Armalya Pritazahra
**BACKGROUND:** Drug-resistant tuberculosis remains a major public health challenge with substantial associated morbidity and mortality. Management requires complex, individualized treatment regimens. Emerging evidence suggests that contemporary antituberculosis agents for drug-r…