Showing 151–175 of 200 documents
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Borgio JF, Rasdan AS, Sonbol B, Alhamid G, Almandil NB, et al.
We aimed to identify the prevalence and emerging status of multidrug-resistant bacteria and fungi and their associated mortality in nine countries in the Arabian Peninsula. Original research articles and case studies regarding multidrug-resistant bacteria and fungi in the Arabian…
K S S, Saldanha PRM, Kushwah S, Prabhu AS
Introduction In spite of having BCG vaccination and tuberculosis control program for the last 50 years, prevalence of tuberculosis continues to be high in India. Inadequate diagnostic methods, suboptimal treatment and monitoring, and the lack of vigilant reporting system are some…
Sharma D, Sharma S, Sharma J
…action), host-centric (immunomodulatory agents, therapeutic vaccines, immune and cellular therapies) and nano-based drug/vaccine delivery should be used singly or in combination. Diverse types of nano-carriers have assessed as auspicious diagnostic and drug delivery systems. In t…
Sommer R, Cole ST
Worldwide, tuberculosis (TB) is the leading cause of death due to infection with a single pathogenic agent, Mycobacterium tuberculosis In the absence of an effective vaccine, new, more powerful antibiotics are required to halt the growing spread of multidrug-resistant strains and…
Naveed M, Waseem M, Mahkdoom I, Ali N, Asif F, et al.
… plants, gene-editing methods, nanomaterials, and bacterial vaccines that will fight MDR bacteria in the future.
Kumar TS, Josephine A, Sreelatha T, Azger Dusthackeer VN, Mahizhaveni B, et al.
Ethnopharmacological relevance The multidrug-resistant (MDR) pathogen, Mycobacterium tuberculosis, still remains as one of the major threat to mankind, despite the availability of a live attenuated vaccine and effective antibiotics. Marine microalgae, at all times, act as a key r…
Capeding TPJ, Rosa JD, Lam H, Gaviola DG, Garfin AMC, et al.
BACKGROUND: The Philippines aims to accelerate TB reduction through the provision of universally accessible and affordable services. The objectives of this paper are to estimate the costs of TB services and interventions using a health systems´ perspective, and to explore cost di…
Saiboonjan B, Roytrakul S, Sangka A, Lulitanond V, Faksri K, et al.
The existence of latent tuberculosis infection (LTBI) is one of the main obstacles hindering eradication of tuberculosis (TB). To better understand molecular mechanisms and explore biomarkers for the pathogen during LTBI, we cultured strains of Mycobacterium tuberculosis ( Mtb ) …
Nijman RG, Bressan S, Brandenberger J, Kaur D, Keitel K, et al.
This joint statement by the European Society for Emergency Paediatrics and European Academy of Paediatrics aims to highlight recommendations for dealing with refugee children and young people fleeing the Ukrainian war when presenting to emergency departments (EDs) across Europe. …
Jelińska A, Zając M, Dadej A, Tomczak S, Geszke-Moritz M, et al.
Background Tuberculosis (TB) has been present in the history of human civilization since time immemorial and has caused more deaths than any other infectious disease. It is still considered one of the ten most common epidemiologic causes of death in the world. As a transmissible …
Jagadeesh S, Wood E
Abstract Case report - Introduction Back pain is one of the common musculoskeletal presentations to GPs and rheumatologists. While common causes are frequent, our patient required extensive investigation to reach a clinical diagnosis. This case draws attention to complexities inv…
Vashi K, Pathak YV, Patel J
Tuberculosis (TB) is a highly infectious disease, and it has the highest global burden on India with 21% prevalence rate and 27% of patients who do not receive pertinent medical treatment. Although India spends 23 billion dollars annually towards medical expenses for TB, India st…
Kock R, Michel AL, Yeboah-Manu D, Azhar EI, Torrelles JB, et al.
Despite slow reductions in the annual burden of active human tuberculosis (TB) cases, zoonotic TB (zTB) remains a poorly monitored and an important unaddressed global problem. There is a higher incidence in some regions and countries, especially where close association exists bet…
Marimani M, Ahmad A, Stacey S, Duse A
…vestigation may potentially be used for generation of novel vaccines and therapeutic compounds capable of neutralising MDR TB-HIV and HIV-1 infection.
Hadi SA, Kolte IV, Brenner EP, Cunha EAT, Simonsen V, et al.
After nearly a century of vaccination and six decades of drug therapy, tuberculosis (TB) kills more people annually than any other infectious disease. Substantial challenges to disease eradication remain among vulnerable and underserved populations. The Guarani-Kaiowá people are …
Zhang Y, Zhao R, Zhang Z, Liu Q, Zhang A, et al.
Objective Pediatric tuberculosis (TB) is one of the top ten causes of death in children. Our study was to analyze influencing factors of multidrug-resistant tuberculosis (MDR-TB) and validation of whole-genome sequencing (WGS) used in children with drug-resistant TB (DR-TB). Meth…
Hadizadeh Tasbiti A, Badmasti F, Siadat SD, Fateh A, Yari F, et al.
Tuberculosis (TB) as a public health crisis is caused by the intracellular bacterium Mycobacterium tuberculosis. Detection of immunogenic proteins in TB is valuable for the development of diagnostic tests, vaccine formulations and monitoring treatment outcome. In this study, we d…
Sema Aytaç, PhD
Tuberculosis is a chronic, necrotic infectious disease with very different clinical appearances, caused by a group of mycobacteria defined as M. tuberculosis complex. Although there is a vaccine and can be treated with combined medications, this health problem remains important a…
Megan Murray, MD, ScD
The purpose of this study is to better understand tuberculosis (TB) and the risk of infection with TB, in Peru. TB is a disease that is caused by bacteria and transmitted through droplets in the air that come from the lungs of an infected person. The risk of infection will be com…
Roohallah Yousefi
…nting public health measures and conducting research on new vaccines are essential in reducing relapse rates and effectively controlling TB.
Nayara Melo dos Santos, Bruna Mariah Muller, Brenno de Sousa Bezerra, Carla Yakabi, Mailla Bergman
Cutaneous tuberculosis is an extrapulmonary form caused by Mycobacterium tuberculosis or M. bovis, and may occur through exogenous inoculation or endogenous dissemination. Its manifestations include tuberculous chancre, verrucous tuberculosis, orificial tuberculosis, miliary tube…
Shambhu Joshi, Prarambhika Khadka
Abstract Background Nepal which have open borders with India and China faces a high burden of tuberculosis (TB), with an annual incidence of 70,000 cases and 18,000 deaths. Despite advancements in treatment, the increasing misuse of over-the-counter antibiotics, including second-…
Dr. Vanita B. Wadewale, Natkar Kalpna Gundaji
… hinder control efforts. Continued research toward powerful vaccines, rapid diagnostics, and shorter drug regimens is essential for TB elimination.
Markus Depfenhart, Drieke Van der Merwe, Suraj P. Parihar, Kobus Venter, Theunis T. Cloete, et al.
…ved, ultimately leading to more effective TB treatments and vaccines. This study aims to evaluate the Kramnik model by investigating the efficacy of a novel Pheroid ® formulation containing traditional TB therapeutics in the C3HeB/FeJ Kramnik mouse model. The potential and limita…
Dwivedi M, Mukhopadhyay S, Yadav S, Dubey KD
…se caused by Mycobacterium tuberculosis. Although there are vaccines and drugs available to treat the disease, they are not efficient, moreover, multidrug-resistant TB (MDR-TB) become a major hurdle in its therapy. These MDR strains utilize the multidrug efflux pump as a decisive…