Showing 151–175 of 200 documents
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Faust L, McCarthy A, Schreiber Y
…lity of the TST compared to IGRAs for LTBI detection in the pediatric population also remains contested. Conclusions Relevant strategies for targeted screening in the Canadian Indigenous context include community-level incidence-based screening (screening based on geographic loca…
Melnychuk L, Perlman-Arrow S, Lisboa Bastos M, Menzies D
…ethods and quality of AE reporting in the studies reviewed, pediatric populations had a very low incidence of AE with all TPT regimens reviewed. In adults, compared to mono-H regimens all rifamycin-based regimens were safer, although 4R had the lowest incidence of TPT-related AE …
Jaganath D, Beaudry J, Salazar-Austin N
…ng diagnostics and therapeutic regimens that aim to improve pediatric TB detection and outcomes.
Ebru Yalçın, Nagehan Emiralioğlu, Gökçen Dilşa Tuğcu, Sanem Eryılmaz, Mina Hızal, et al.
…35) who were followed at Hacettepe University Department of Pediatric pulmonology were included and vitamin D, LL-37 levels were analyzed. Demographic characteristics, clinical, radiological, microbiological findings, TST results, treatment status were recorded. <b>Results:</b> I…
Mikhail Vladimirsky, Valentina Aksenova, Sergey Smerdin, Nelli F. Khabibullina, Anastasia Samoilova
…hus, the set of the 3 in vitro tests, may possibly identify pediatric patients who need in-depth examination and longer specific therapy.
Kampmann B, Seddon JA, Paton J, Nademi Z, Keane D, et al.
…ctious case of TB in their household were recruited from 11 pediatric TB clinics. TST and IGRA were performed at baseline, with IGRA repeated at 8 weeks and TST repeated if initially negative. Children were treated according to 2006 NICE guidelines and followed for 24 months. Mea…
Comella-Del-Barrio P, Abellana R, Villar-Hernández R, Jean Coute MD, Sallés Mingels B, et al.
In recent years, pediatric research on tuberculosis (TB) has focused on addressing new biomarkers with the potential to be used as immunological non-sputum-based methods for the diagnosis of TB in children. The aim of this study was to characterize a set of cytokines and a series…
Starshinova A, Zhuravlev V, Dovgaluk I, Panteleev A, Manina V, et al.
…test (ELISPOT and QFT) results was observed in the examined pediatric population (n = 696), with a Diaskintest cutoff ≥5 mm: the kappa consistency indices were 1.000 and 0.937, for ELISPOT and QFT, respectively. A high sensitivity of Diaskintest, comparable with the IGRA tests, w…
Sun L, Qi X, Guo Y, Qi H, Li J, et al.
…ifying and prioritizing at-risk populations is critical for pediatric tuberculosis control. We aimed to identify a latent tuberculosis infection (LTBI) screening strategy that is appropriate for the Chinese context among children with different TB exposure levels and to explore i…
Ndzi EN, Nkenfou CN, Mekue LM, Zentilin L, Tamgue O, et al.
…h is easy to collect compared to sputum it could be used in pediatric and extra-pulmonary TB cases.
Lima LM, Aurilio RB, Fonseca AR, Parente AAAI, Sant'Anna MFBP, et al.
…. Conclusions The study revealed a low rate of active TB in pediatric patients using biologic therapy. Screening for LTBI before initiating biologics should be done in all patients, and treatment, in cases of positive screening, plays a critical role in preventing progression to …
Pop R, Kaelin MB, Kuster SP, Sax H, Rampini SK, et al.
…nfection. The secondary attack rate in this study including pediatric and adult contacts was 0.29%. Conclusion This investigation highlighted the low transmission rate of sputum smear positive miliary TB in a particularly highly susceptible population as infants. Our expert defin…
…ith LTBI in the US. We explored physicians’ perspectives on pediatric LTBI diagnosis and care, and strategies to improve care. Methods We conducted a convergent mixed methods study with physicians in Massachusetts. Participants were purposefully sampled from primary care clinics …
Digambar Behera
…00,000 died[4] and in India about 342,000 incident cases of pediatric TB are estimated to occur every year accounting for 31% of the global burden and 13% of the overall TB burden in the country.[5] The association between poverty and COVID-19 is unclear. TB will be associated wi…
Diel R, Nienhaus A
…rted in household settings. However, as the preselection of pediatric contacts appeared in most cases to be vague, the data found in the literature probably underestimates the actual risk.
Plascencia Hernández A, González Sánchez RM, Hernández Cañaveral II, Luévanos Velázquez A, Martínez Arce PA, et al.
…ts an opportunity in the diagnosis of LTBI, particularly in pediatric HIV- patients. This is the first study that compares the two tests (TST and QFT) in children with HIV-infection in Guadalajara, Mexico.
Son M, Park YS, Jung MH, Kang JH, Choi UY
…ildren with a known history of TB contact are considered as pediatric high-risk groups for LTBI, and consequently, LTBI screening is only provided to these children. However, to reduce the incidence of TB, the high-risk groups that undergo LTBI screening should be expanded. This …
A. A. Elov, M. A. Vladimirskiy, S. V. Smerdin, O. I. Elufimova
…jects and methods. Peripheral blood samples collected in 36 pediatric patients with latent tuberculosis infection and 24 patients aged 1 to 16 years undergoing in-patient treatment for pulmonary tuberculosis were tested. A modified method for isolating messenger RNA and reverse t…
Karishma Saran, Tiziana Masini, Isaac Chikwanha, Gregory Paton, Rosalind Scourse, et al.
…untries, respectively, but short-course (9-month) and newer pediatric regimens by only 13 and 14 countries, respectively. Guidelines in all countries included preventive treatment of latent TB infection for child TB contacts and people living with HIV/AIDS, but only four extended…
Lombardi G, Pellegrino MT, Denicolò A, Corsini I, Tadolini M, et al.
… use of QFT-IT as a complementary test for the diagnosis of pediatric TB even under 2 years of age. Our observations could be applicable to the new version of the test, QuantiFERON-TB Gold Plus, which has recently been shown to have similar sensitivity in active TB, although data…
Père-Joan Cardona, Synne Jenum, Novel N. Chegou
…e and highly sensitive tools are crucial. Stool testing for pediatric TB and urine-based LAM testing in HIV patients represent important steps in this direction. Yet, affordability and accessibility remain major barriers (10).Finally, understanding TB progression requires us to c…
Modi AR, Miranda CC, Procop GW, Foster CB, Harrington S, et al.
…ly identify cases and address community risk. We describe a pediatric intensive care unit nurse with latent TB infection who developed hemoptysis and a lung infiltrate concerning for active TB. Her evaluation and contact investigation were facilitated by our institution's command…
Deepak V. Sawant, Shivaji H. Pawar
…osing of latent TB, drug-resistant TB, and HIV co-infected, pediatric TB remains still a challenge. There are so many low sensitive conventional TB diagnosis methods are available which are responsible for delay in early-stage TB diagnosis. There is an urgent demand for precise a…
Boskovska K, Naceva-Fustic S, Simonovska L, Dilberovska M, Dacevski D, et al.
…med to evaluate the importance of IFN-γ in the diagnosis of pediatric TB and LTBI and to compare the IFN-γ levels. Methods We analysed 100 patients examined for possible M. tuberculosis infection or disease at the Institute of Respiratory Diseases in Children, Kozle, Skopje. Pati…
Özlem Özgür Gündeşli̇oğlu, Gönül Tanır
…test was reapplied to all patients. Results: A total of 106 pediatric patients (25.6%) with tuberculosis contact and 81 (76.4%) with latent tuberculosis infection were included in this study. The mean pre-treatment tuberculin skin test value of the patients was 16.57 4.124 mm and…