Showing 151–175 of 200 documents
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Akhilesh Kunoor, Arya Kumar, Binny Prabhu, Vidya Menon, Fathima Shameen, et al.
… than 50% of tuberculosis (TB) care. Inappropriate anti- TB drug prescriptions are a significant factor in drug-resistant TB. Effective engagement of the private sector, in partnership with the national TB control program, is essential for achieving TB elimination. Here, we share…
Pace D, Pellegrino R, Dalpiaz I, Renni M, Galli L, et al.
…od and provide information on M. tuberculosis detection and drug-resistance-associated mutations in less than 2 hours. This retrospective single-center study aimed to evaluate the accuracy of GeneXpert and GeneXpert Ultra for the diagnosis of pediatric TB. Methods This retrospect…
Sevtap Şenoğlu, Meyha Şahin, Filiz Pelivanoğlu, Gönül Şengöz
…d in non-pulmonary samples against major tuberculosis (TBc) drugs, including isoniazid (INH), rifampin (RIF), streptomycin (SM), and ethambutol (EMB), using the Mycobacterium Growth Indicator Tube (MGIT) method.Methods:In this retrospective, cross-sectional study, samples taken f…
Nazlı Arslan, Müge Hacer Özkarataş, Nuran Esen, Aydan Özkütük
…rculosis complex and its susceptibility to antituberculosis drugs at Dokuz Eylül University Hospital. Method: In our study, the results of all samples sent between January 2013 and November 2019 were examined retrospectively for the presence of M. tuberculosis complex and drug su…
Muneer A, Macrae B, Krishnamoorthy S, Zumla A
… surgical management, and monitoring response to treatment. Drug-sensitive TB requires 6-9 months of WHO-recommended standard treatment regimens. Drug-resistant TB requires 12-24 months of therapy with toxic drugs with close monitoring. Surgical intervention as an adjunct to medi…
Karthikeyan Sundaram, Sridhar Rathinam
Drug-resistant tuberculosis is a global challenge to treat. Advanced drug-delivery methods are needed to enhance drug efficiency with fewer side effects. Nanoparticle-based drug delivery systems increase medication to improve antitubercular therapy. Thus, the review aims to evalu…
Mete Yesil A, Yalcin E, Ademhan Turhal D, Emiralioglu N, Dogru D, et al.
…21.4% of patients with culture growth, at least one anti-TB drug resistance was found. The mean duration of treatment of patients treated according to the national guideline was 8.6 months (range = 6-36 months). Recovery was seen in 91.4% of patients. Conclusion . The most import…
S Abid, Rakesh Kumar, Pankaj Kumar Yadav, Raman Kumar
…l for improving patient outcomes and preventing relapse and drug resistance. The study aims to determine the optimal duration of drug therapy for spinal tuberculosis and to evaluate the clinical, radiological, and neurological outcomes associated with different treatment duration…
Khan AH, Sulaiman SAS, Hassali MA, Khan KU, Ming LC, et al.
…5% CI 1.09-1.34), alcoholics (OR = 4.91, 95% CI 4.04-5.96), drug abusers (OR = 7.43, 95% CI 5.70-9.60) and presence of co-morbid condition (OR = 1.27, 95% CI 1.16-1.40) all showed significant association with smoking habits. This study found that 3236 (75.0%) patients were succes…
Halime Araz, Saliha Kazcı, Fatma Eser, Adalet Aypak
…ositivity in 31.2%. AFB staining was positive in 25.8%, and drug susceptibility testing was performed in 27.9%, revealing resistance in two patients. Standard four-drug anti-TB therapy was initiated in 95.7% of cases, with a median duration of 6 months (range: 1–13). Surgery was …
İhsan Topaloğlu, Yelda Varol, Can Biçmen, Onur Karaman, Serir Aktoğu Özkan
…s in detecting tuberculosis (TB) and identifying rifampicin resistance. This research aimed to examine their diagnostic accuracy and clinical relevance. **MATERIALS AND METHODS:** This retrospective cohort study included patients aged 18 years and older with pulmonary or extrapu…
Kun Li, Long Li
…study characterized mutation patterns within the rifampicin resistance-determining region (RRDR) of thegene (codons 507-533), targeted by Xpert MTB/RIF probes, inisolates from Southwest China. Regional molecular profiles were and compared regional profiles against global datasets…
Kumar K, Mathew JL
…iagnostic test for pulmonary TB and detection of rifampicin resistance. But its place vis-à-vis the previously recommended GeneXpert has not been clarified. Further, the limited diagnostic accuracy of Xpert Ultra in some biological specimens like nasopharyngeal aspirates, and the…
Park M, Kon OM
… accessible platform to diagnose TB and identify rifampicin resistance within 2 h. Areas covered The diagnostic accuracy and the clinical role of Xpert MTB/RIF and Xpert Ultra in the different forms of EPTB. Expert opinion Whilst significant advances have been made in TB diagnost…
World Health Organization
…dations on the diagnosis of tuberculosis (TB), detection of drug-resistant TB and testing for TB infection. The publication consolidates, for the first time, operational guidance previously issued separately for TB diagnosis and TB infection testing, and aligns implementation adv…
Shital Patil, Swati Patil, Akshata Patil
…to NTEP guided ATT schedule as per weight band in line with drug sensitive tuberculosis. He has shown good clinical and radiological response in first six weeks to ATT and later showed clinical and radiological worsening. We further reassessed and confirmed drug sensitive tubercu…
Dilia Fontalvo-Rivera, Enrique Mazenett, Luisana Cárcamo-Marrugo, Claudia Llerena-Polo, Doris Gómez‐Camargo
… has some common characteristics that can lead to increased resistance to anti-TB drugs and undesired outcomes. In Cartagena de Indias, Colombia, an increase in TB cases has been observed in immigrants. Our objective is to describe the clinical and microbiological characteristics…
Mehmet Serkan Özkent, Mehmet Balasar, Mehmet Giray Sönmez, Muzaffer Tansel Kılınç, Pembe Oltulu, et al.
…mary care. The minimum treatment is at 6 months. In case of resistance against first-line drugs, second-line antituberculosis drugs are among the options to be used for treatment. In severe fibrosis, corticosteroid treatment is among the options which can be added to antitubercul…
Wang Y, Tan J, Lei L, Yuan Y, Li W, et al.
…of Xpert MTB/RIF, a PCR test that can detect MTB as well as resistance to an important drug, rifampicin (RIF), in UTB particularly, for the early identification of UTB. Methods 180 participants with clinically presumptive UTB whose urine samples were chosen for urine sediment sme…
Kim SK, Chang J, Choi SH, Sung H, Kim MN
…or the detection of Mycobacterium tuberculosis and rifampin resistance. This study evaluated the performance of the Xpert MTB/RIF assay in extrapulmonary specimens. Methods Acid-Fast Bacilli (AFB) smear, culture, and Xpert MTB/RIF were performed on extrapulmonary specimens. Mycob…
Alexander W Kay, Maia Madison, Katie Scandrett, Tara Ness, Pauline Amuge, et al.
…t detects Mycobacterium tuberculosis complex and rifampicin resistance. This is an update of a Cochrane review first published in 2020 and last updated in 2022. Parts of the current update informed the 2024 WHO updated guidance for the diagnosis of tuberculosis. **OBJECTIVES:** …
Kohli M, Schiller I, Dendukuri N, Dheda K, Denkinger CM, et al.
…ection of Mycobacterium tuberculosis complex and rifampicin resistance in sputum specimens. This Cochrane Review assessed the accuracy of Xpert in extrapulmonary specimens. Objectives To determine the diagnostic accuracy of Xpert a) for extrapulmonary TB by site of disease in peo…
Svensson E, Folkvardsen DB, Rasmussen EM, Lillebaek T
…azid (INH) are the two most effective first-line antibiotic drugs for the treatment of tuberculosis (TB). The new FluoroType MTBDR (FT-MTBDR) real-time PCR is intended to detect INH and RIF resistance mutations as a second step following a primary Mycobacterium tuberculosis compl…
Denis Kholtobin, Ekaterina Kulchavenya
…the kidneys and urinary tract is often diagnosed late, when drug therapy is not enough and surgical treatment is required. A total of 78 national and foreign publications dedicated to surgical treatment of patients with urogenital tuberculosis were analyzed. Various surgical tech…
Maryam Hashemi, Maryam Dehghan
…rately and rapidly. Treatment of genital TB requires a four-drug regimen due to the high recurrence rate and the prevalence of drug-resistant strains. In cases of large abscesses or fallopian tube obstruction, surgical intervention may be necessary. **CONCLUSION:** Given the inc…