Showing 151–175 of 200 documents
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Mukherjee N, Julián E, Torrelles JB, Svatek RS
The Mycobacterium bovis Bacillus Calmette et Guérin (BCG) vaccine was generated in 1921 with the efforts of a team of investigators, Albert Calmette and Camille Guérin, dedicated to the determination to develop a vaccine against active tuberculosis (TB) disease. Since then, BCG v…
Ning H, Kang J, Lu Y, Liang X, Zhou J, et al.
Bacillus Calmette-Guérin (BCG) is a licensed prophylactic vaccine against tuberculosis (TB). Current TB vaccine efforts focus on improving BCG effects through recombination or genetic attenuation and/or boost with different vaccines. Recent years, it was revealed that BCG could e…
Fan X, Zhao X, Wang R, Li M, Luan X, et al.
…-19 among infectious diseases. The Bacillus Calmette-Guérin vaccine (BCG), the only licensed TB vaccine, is ineffective against adult TB. Therefore, there is an urgent need to develop new effective vaccines. Methods In this study, we developed a novel multistage subunit vaccine (…
Gyu Choi H, Woong Kwon K, Jae Shin S
…exemplified by SARS-CoV-2, has emphasized the importance of vaccines in thwarting infection and curtailing the progression of severe disease. The scourge of tuberculosis (TB), emanating from the Mycobacterium tuberculosis (Mtb) complex, has inflicted a more profound toll in terms…
Pelzer PT, Seeley J, Sun FY, Tameris M, Tao L, et al.
Recently, two Phase 2B tuberculosis vaccine trials reported positive efficacy results in adolescents and adults. However, experience in vaccinating these age groups is limited. We identified potential implementation strategies for the M72/AS01E vaccination and BCG-revaccination-l…
Sable SB, Posey JE, Scriba TJ
…ive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer and more effective vaccine than BCG is urgently required. More than a dozen TB vaccine candidates are under active evaluation in clinical trials aimed to prevent infection, disease, and recurrence. …
Xinfeng Li, Xinyu Tao, Mingyue Zhong, Yiyao Wang, Heng Xue, et al.
…n is a cornerstone of disease control, the only licensed TB vaccine, Bacille Calmette-Guérin (BCG), shows limited efficacy in adults. There is thus a critical need for more effective vaccines. Multi-epitope vaccines, which incorporate key epitopes from multiple antigens, off…
Alexa Giovanatti, Adrienne E Shapiro
…e leading infectious cause of death worldwide, yet the only vaccine currently available is the pediatric BCG, which has poor effectiveness in preventing TB in adolescents and adults. A TB vaccine for this older age group is projected to prevent 4.6-8.5 million deaths by 2050 and …
Tanzeela Sameen Saeed, Maythem Saeed, Muhammad Fahad Abdullah, M. N. Qureshi, Armeen Saeed
…1.25 million deaths annually. The Bacillus Calmette–Guérin (BCG) vaccine provides limited protection against adult pulmonary TB, prompting the need for novel strategies. mRNA vaccines, successful in the fight against COVID-19, are now being explored for TB prevention. Methods We …
Wang X, Du J, Zhang Y, Zhu T, Mao L, et al.
… infectious disease worldwide, and Bacille Calmette-Guerin (BCG) remains the only TB vaccine licensed for clinical use. As there is little evidence that BCG is effective in adults, there is an urgent need for a safe and effective vaccine to control TB in adults. In this study, we…
Ji N, Mukherjee N, Reyes RM, Gelfond J, Javors M, et al.
Background Although intravesical BCG is the standard treatment of high-grade non-muscle invasive bladder cancer (NMIBC), response rates remain unsatisfactory. In preclinical models, rapamycin enhances BCG vaccine efficacy against tuberculosis and the killing capacity of γδ T cell…
Rodo MJ, Rozot V, Nemes E, Dintwe O, Hatherill M, et al.
…due to infectious disease, requires a highly efficacious TB vaccine. Many TB vaccine candidates are in pre-clinical and clinical development but only a few can be advanced to large-scale efficacy trials due to limited global resources. We aimed to perform a statistically rigorous…
Jackson S, McShane H
…ientific advancements, contributing to the licensure of new vaccines for many pathogens. Despite being one of the world's oldest known pathogens, there are still significant gaps in our knowledge surrounding the immunobiology of Mycobacterium tuberculosis (M. tb). Furthermore, th…
Cao X, Fu YX, Peng H
…portion of the world's population. The current tuberculosis vaccine, bacille Calmette-Guérin (BCG), offers limited protection against pulmonary tuberculosis in adults, underscoring the critical need for innovative vaccination strategies. Cytokines are pivotal in modulating immune…
Eunkyung Shin, Jin-Seung Yun, Young-Ran Lee, Hye‐Ran Cha, Soo-Min Kim, et al.
…million deaths worldwide in 2022. Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB); however, it has limited protective efficacy in adults. In this study, we constructed a recombinant vaccinia virus expressing Ag85B from M. tuberculosis using a…
Mohsen Karbalaei, Kiarash Ghazvini, Masoud Keikha
…ion infected people in 2018, 1.6 million died. Although the BCG vaccine has been used for about a hundred years, it is only effective in children, but is not able to produce a protective and reliable immunity against adult pulmonary TB. Hence, using an alternative vaccine with hi…
Mada Ferreira, MD
…f a recombinant urease C-deficient listeriolysin expressing BCG vaccine strain (VPM1002) as a safe, well tolerated and efficacious vaccine against tuberculosis (TB) for residents in endemic areas and persons at risk in non-endemic areas. The new vaccine should be at least as pote…
Bianco C, Lesellier S, Barrat J, Richomme C, Boschiroli ML, et al.
…linical systemic dissemination of Bacillus Calmette-Guérin (BCG) is described in a captive badger (Meles meles) with lymphoma. An adult female European badger was vaccinated per os with BCG and after 8 weeks post-mortem examination identified marked lymphadenomegaly and multinodu…
Arinaminpathy N, Rade K, Kumar R, Joshi RP, Rao R
…e in meeting the end tuberculosis (TB) goals. While certain vaccine candidates in advanced stages of clinical trials raise hope for the future availability of new tools, in the immediate term, there is also increasing interest in Bacille Calmette-Guérin revaccination among adults…
Walker EM, Merino KM, Slisarenko N, Grasperge BF, Mehra S, et al.
Background Although BCG vaccine protects infants from tuberculosis (TB), it has limited efficacy in adults against pulmonary TB. Further, HIV coinfection significantly increases the risk of developing active TB. In the lack of defined correlates of protection in TB disease, it is…
Christine M Qabar, Allison W Roberts, Lucas M Waldburger, Edward E K Baidoo, Emine Akyuz Turumtay, et al.
…urgent need to develop a more efficacious anti-tuberculosis vaccine as the current live-attenuated vaccine strain BCG fails to prevent pulmonary infection in adults. In this study, we leverage a synthetic biology approach to engineer BCG to produce more (E)-4-hydroxy-3-methyl-but…
Alemnew F. Dagnew
…from a single infectious agent. The BacilleCalmette-Guérin (BCG) vaccine is currently the only licensed TB vaccine;however, it offers little to no protection against pulmonary TB in adults. Theinvestigational M72/AS01E-4 vaccine, developed by GSK, has shown promisingresults in Ph…
Alemnew F. Dagnew
…from a single infectious agent. The BacilleCalmette-Guérin (BCG) vaccine is currently the only licensed TB vaccine;however, it offers little to no protection against pulmonary TB in adults. Theinvestigational M72/AS01E-4 vaccine, developed by GSK, has shown promisingresults in Ph…
Gurudeeban Selvaraj, Satyavani Kaliamurthi, Dongqing Wei
…long-standing shortcomings of the Bacillus Calmette-Guérin (BCG) vaccine in preventing adult pulmonary tuberculosis highlight the urgent need for improved alternatives. In this issue, one study takes a rational genetic approach by creating progressively attenuated M. tuberculosis…
Shaista Arif, Farheen Aslam
…um tuberculosis (Mtb) has afflicted humanity for centuries. BCG is the only vaccine available for TB, but it shows limited protective efficacy in adults. Therefore, there is an urgent need to develop universal vaccines for controlling TB worldwide. In this study, four conserved m…