Showing 151–175 of 200 documents
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Wang Y, Sun Y, Zheng Y, Yang Y, He L, et al.
…uses of human death in the world. Bacillus Calmette-Guérin (BCG) provides limited protection in adolescents and adults. To explore the factors reducing efficacy of BCG vaccine, we assess the impacts of interleukin (IL)-10 and alarmins S100A8/A9 on T-cell memory. We found that BCG…
James M. Trauer, Andrew Kawai, Anna K. Coussens, Manjula Datta, Bridget M Williams, et al.
Abstract Background The variable efficacy observed in studies of BCG vaccination is incompletely explained by currently accepted hypotheses, such as latitudinal gradient in non-tuberculous mycobacteria exposure. We investigated heterogeneity in BCG vaccination in the context of p…
Sihang Dong, Shuang Wu, Ke Liang, Hui Zhang, Fangzheng Guo, et al.
…URPOSE:** The only World Health Organization (WHO)-approved vaccine for tuberculosis (TB), Bacillus Calmette-Guérin (BCG), shows limited efficacy, particularly against adult pulmonary TB. Moreover, traditional subunit vaccines often suffer from poor immunogenicity. To addres…
Bhaskar A, Pahuja I, Negi K, Verma A, Ghoshal A, et al.
Bacille Calmette-Guerin (BCG) generates limited long-lasting adaptive memory responses leading to short-lived protection against adult pulmonary tuberculosis (TB). Here, we show that host sirtuin 2 (SIRT2) inhibition by AGK2 significantly enhances the BCG vaccine efficacy during …
Dereck Tait, MD
…is clinical trial will evaluate safety, immunogenicity, and efficacy (prevention of Mtb infection as measured by IGRA conversions) of H56:IC31 in remotely BCG vaccinated adolescents. This clinical trial will evaluate safety, immunogenicity, and prevention of Mtb infection, (meas…
Mustafa AD, Kalyanasundram J, Sabidi S, Song AA, Abdullah M, et al.
…ng prevented and controlled by the Bacille Calmette Guérin (BCG) vaccine, the protective efficacy is highly variable and substandard (0-80%) in adults. Therefore, novel and effective tuberculosis vaccine that can overcome the limitations from BCG vaccine need to be developed. Res…
Yuqin Xue, Chao Fan, Yun Huang, Ying Jin, Yijing Zheng, et al.
…, as the currently available Bacillus Calmette-Guérin (BCG) vaccine provides only limited protection against adult pulmonary TB. This study aimed to develop and evaluate a novel fusion vaccine that combines the safety of BCG, the broader antigenic repertoire of Mycobacterium…
Zhuang Li, Yilu Zhao, Ling Yang, Linsheng Li, Zhaoyang Ye, et al.
…vent and control TB, the existing Bacillus Calmette–Guérin (BCG) vaccine exhibits limited protective efficacy in adult pulmonary TB. Therefore, developing a novel TB vaccine is an urgent need. This study designed a novel multi-epitope vaccine (MEV) to combat MTB infection, utiliz…
Angelidou A, Conti MG, Diray-Arce J, Benn CS, Shann F, et al.
Background Bacille Calmette-Guérin (BCG), the live attenuated tuberculosis vaccine, is manufactured under different conditions across the globe generating formulations that may differ in clinical efficacy. Innate immune recognition of live BCG contributes to immunogenicity sugges…
Craig SR, Lahey T, Dixit A, Fordham von Reyn C
Background The current vaccine against tuberculosis, BCG, is effective when given in most TB-endemic countries at birth but has diminished efficacy against pulmonary TB after 15-20 years. As a result, new booster vaccines for adolescents and adults are being developed to realize …
Song D, Ji J, Yang S, Chen Z, Liu J, et al.
…s, remains a major global public health threat. The limited efficacy of the current Bacillus Calmette-Guérin (BCG) vaccine against adult pulmonary TB highlights the urgent need for improved vaccine strategies. To address this, we engineered a recombinant BCG strain, designated rB…
Beatrice Napoli
…days, it comprises the use of the Bacillus Calmette-Guérin (BCG) vaccine, developed one century ago but still the first-line weapon against TB. Despite evident challenges, that include variability in efficacy, vaccination with BCG has been proven to significantly reduce the incid…
Mark Hatherill, MD
… Infection with Mycobacterium tuberculosis of AERAS-404 and BCG Revaccination in Healthy Adolescents This Phase II, randomized, 3-arm, placebo controlled, partially blinded, clinical trial will be conducted in 990 healthy, HIV-uninfected, QFT-GIT negative, previously BCG vaccina…
Mingming Zhang, Syed Luqman Ali, Yuan Tian, Aigul Abduldayeva, Shuang Zhou, et al.
…TB) remains a pressing global health crisis. The inadequate efficacy of the BCG vaccine against adult pulmonary TB underscores the urgent need for novel, effective vaccines. This study aimed to design a novel mRNA vaccine candidate against TB using a rational immunoinformatics ap…
Singh AK, Srikrishna G, Bivalacqua TJ, Bishai WR
Bacillus Calmette-Guérin (BCG) vaccine is an attenuated live strain of Mycobacterium bovis. It may be the most widely used vaccine in human history and is the only licensed human tuberculosis (TB) vaccine available. Despite its excellent safety history, a century of use in global…
Weng CH, Saal A, Butt WW, Bica N, Fisher JQ, et al.
…ited data on effective therapies. Bacillus Calmette-Guérin (BCG) vaccine, a live-attenuated strain derived from an isolate of Mycobacterium bovis and originally designed to prevent tuberculosis, has shown some efficacy against infection with unrelated pathogens. In this study, we…
Lázaro M Marques-Neto, Monalisa M Trentini, Ana Carolina R Moreno, Silas F Eto, Ana Carolina O Carvalho, et al.
… remains a global public health challenge, with the current BCG vaccine providing limited efficacy in adults, and available treatments being lengthy and debilitating. To overcome these challenges, we have previously developed a recombinant BCG strain expressing the detoxifiedHeat…
Szachniewicz MM, van den Eeden SJF, van Meijgaarden KE, Franken KLMC, van Veen S, et al.
…nd a quarter of the global population. The sole licensed TB vaccine, Mycobacterium bovis Bacillus Calmette-Guérin (BCG), shows variable efficacy, particularly among adolescents and adults, underscoring the pressing need for more effective vaccination strategies. The administratio…
Dongmei Song, Jing Ji, Shuo Yang, Zhaohang Chen, Jiahe Liu, et al.
…s, remains a major global public health threat. The limited efficacy of the current Bacillus Calmette-Guérin (BCG) vaccine against adult pulmonary TB highlights the urgent need for improved vaccine strategies. To address this, we engineered a recombinant BCG strain, designat…
Buyun Xu, Mengjuan Yuan, Lisa Yang, Lan Huang, Jingxin Li, et al.
…erculosis (MTB), is one of the leading infectious causes of adult mortality worldwide. The Bacillus Calmette-Guérin (BCG) vaccine is currently the only approved vaccine for TB prevention, but its protective efficacy against adult pulmonary TB is limited, and it lacks effecti…
Feng Shan, Andrew Simonson, Joshua D. Bromley, Michael C. Chao, Doaa Megahed, et al.
Abstract Description Background The limited efficacy of the BCG vaccine for adult pulmonary Tuberculosis (TB), as well as rising drug resistance, underscores the need for new vaccines and treatments. Concomitant immunity provides strong protection against M. tuberculosis (Mtb) re…
Korompis, Marcellus
…sease and drug resistance is greatest. The only licensed TB vaccine, Bacillus Calmette–Guérin (BCG), offers limited and inconsistent protection against adult pulmonary disease, necessitating the development of more effective vaccination strategies. This thesis explores subunit va…
Helen McShane
…he safety and immunogenicity of candidate tuberculosis (TB) vaccine MVA85A administered by the intramuscular route and the intradermal route in healthy adult individuals who have been previously vaccinated with Bacillus Calmette-Guerin (BCG). We postulate that the intramuscular …
Davood Mansury, Kiarash Ghazvini, Saeid Amel Jamehdar, Ali Badiee, Mohsen Tafaghodi, et al.
BACKGROUND: Due to the ineffectiveness of the BCG vaccine, especially in adult pulmonary tuberculosis (TB), and variable efficacies against childhood forms of TB, developing an effective TB vaccine is a major priority in controlling this disease. The aim of this study was to eval…
Mansury D, Ghazvini K, Amel Jamehdar S, Badiee A, Tafaghodi M, et al.
Background Due to the ineffectiveness of the BCG vaccine, especially in adult pulmonary tuberculosis (TB), and variable efficacies against childhood forms of TB, developing an effective TB vaccine is a major priority in controlling this disease. The aim of this study was to evalu…