Showing 151–175 of 200 documents
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World Health Organization
… of WHO recommendations for the treatment of drug-resistant tuberculosis (DR-TB), including multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB) and rifampicin-susceptible, isoniazid-resistant tuberculosis (Hr-TB). The publication complements the WHO consolidated guideline…
World Health Organization
…ng WHO recommendations on the treatment of drug-susceptible tuberculosis (DS-TB). Developed within the framework of the End TB Strategy, the publication complements the WHO consolidated guidelines on tuberculosis by translating evidence-based policy recommendations into operation…
World Health Organization
…ies the third edition of the WHO consolidated guidelines on tuberculosis, Module 3: diagnosis – rapid diagnostics for tuberculosis detection. The publication presents evidence-to-decision tables developed to support WHO recommendations on the use of rapid diagnostic technologies …
P Chikkahonnaiah, A Surendran, Anaswara KS, Niketa Kamble
Background: Tuberculosis is one of the major public health problem, further complicated by the relentless spread of human immunodeficiency virus (HIV). The incidence of drug resistant TB among HIV patients is now increasing. Treatment outcomes in multidrug-resistant tuberculosis …
de Sousa NF, de Freitas MEG, Sidrônio MGS, Souza HD, Czeczot A, et al.
…inhibited the growth of laboratory strains of Mycobacterium tuberculosis with MIC values ranging from 10 to 20 µM. Importantly, three derivatives were active against two multi-drug-resistant clinical isolates of M. tuberculosis with MIC values similar to pan-sensitive strains. In…
Sichen L, Rui W, Yue Y, Xin L, Youbin C, et al.
…udy is to determine the drug resistance status of pulmonary tuberculosis patients in Jilin Province. Methods: A retrospective survey was conducted on 395 sputum culture TB-positive patients admitted to the tuberculosis hospital in Jilin Province in 2019. Sputum samples were cultu…
Dong-Mei Wang, Qi An, Qing Yang, Yi Liao
…e the demographic and clinical characteristics of pediatric tuberculosis (TB) inpatients diagnosed with resistance to any anti-tuberculosis drug [drug-resistant tuberculosis (DR-TB)] in southwest China. **METHODS:** Patients aged ≤14 years with clinically diagnosed…
Herikurniawan H, Audrey J, Yulianti M, Indira NN, Rumende CM
Tuberculosis (TB) has become one of the global burdens of disease, with increasing morbidity and mortality every year. Tuberculosis can affect not only the lungs but also the extrapulmonary organs. The prevalence of drug-resistant tuberculosis (DR-TB) is rising and has caused a h…
Herikurniawan Herikurniawan, Joanna Audrey, Mira Yulianti, Ni Nyoman Indira, Cleopas Martin Rumende
Tuberculosis (TB) has become one of the global burdens of disease, with increasing morbidity and mortality every year. Tuberculosis can affect not only the lungs but also the extrapulmonary organs. The prevalence of drug-resistant tuberculosis (DR-TB) is rising and has caused a h…
Yaser Jasem1 , Al-khatony2 , Halah Abdulkhaliq Awadh Alhadethy3 , Mahmood Abduljabar Altobjy4
Background and Objective: Pulmonary tuberculosis(PTB) is a serious disease that mainly affects thelungs. The aim of this study was a Comparison between conventional, and molecular methods to diagnoseM.tuberculosis complex (MTBC) and using serum TNF-? levels as a biomarker for eva…
Tavanaee Sani A, Ashna H, Kaffash A, Khaledi A, Ghazvini K
… the most important drugs in the treatment of Mycobacterium tuberculosis is caused by mutations in the 81-base pair region of the rpoB gene encoding the β-subunit of RNA polymerase. This study aimed to characterize the mutations in the rpoB gene associated with rifampin resistanc…
Santosh Shankar Patil, Nilima Sanjay Naik, VR Patil
Tuberculosis (TB) remains a significant global health challenge, with increasing incidence of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) posing a threat to public health. This study aimed to analyze the genetic diversity of M. tuberculosis strains using RAPD fingerpr…
Microbiologist- External Quality Assurance, State TB control Society, Port Blair, Andaman and Nicobar Islands, Keerthivasan Gurumurthy
Introduction: Tuberculosis is a contagious bacterial infection affecting more than 10 million people worldwide. It is a major public health concern in India especially with the increasing numbers of drug-resistant cases of tuberculosis. Lack of early diagnosis, inadequate and ina…
G. Edwar, N. Hayyin, D. Syahdita, Farchan Azzumar, Aulia Fitri Rhamadianti, et al.
…tract RATIONALE: A significant proportion of Drug-Resistant Tuberculosis (DR-TB) patients worldwide remains a global health burden with only 44% of patients receiving treatment. In 2023, the proportion of individuals with Multidrug Resistant/Rifampicin Resistant Tuberculosis (MDR…
Lin WH, Lee WT, Tsai HY, Jou R
… testing (gDST) and phenotypic DST (pDST) for Mycobacterium tuberculosis isolates with disputed (discordance between gDST and pDST results) mutations affect rifampin (RIF)-resistant (RR) and multidrug-resistant (MDR) tuberculosis (TB) treatments due to a lack of practical clinica…
Tilahun M, Ameni G, Desta K, Zewude A, Yamuah L, et al.
Introduction Tuberculosis (TB) is caused by M. tuberculosis complex and remains a major global public health problem. The epidemic remains a threat to sub-Saharan Africa, including Ethiopia, with further emergence of drug resistant TB. We investigated the drug sensitivity pattern…
Getachew Seid, Ayinalem Alemu, Getu Diriba, Betselot Zerihun, Gemechu Tadesse, et al.
**BACKGROUND:** There is a gap between tuberculosis (TB) infection and the onset of clinical TB disease, which makes identifying TB transmission dynamics a prominent challenge. Different reports were made on the concordance of drug-resistance profiles between the household contac…
Bargaje M, Bharaswadkar S, Lohidasan S, Panda BK
…ncentrations as an independent risk factor for unfavourable tuberculosis (TB) outcome. With introduction of daily regimen using fixed dose combinations (FDC) under National Tuberculosis Elimination Programme (NTEP) the existence of suboptimal plasma levels of first-line antituber…
Jingyi Dai, Qiujing Li, Jie Chen, Pei Zhang, Jun Zhao, et al.
**BACKGROUND:** Drug-resistant tuberculosis (TB) pose a significant impact on public health challenge in China. This study aimed to characterize the drug resistance patterns among TB patients at a designated tuberculosis hospital of Yunnan province over the past decade and identi…
Muhammad Bilal Ibrahim, Maria Cristina Cuartas-Mesa, Hiba Noor, Ali Husnain, Mihir Shah, et al.
Introduction: Tuberculosis (TB) is more frequently found among high-risk populations such as immigrants, with HIV, incarcerated, and homeless individuals in the US. it is still a significant public health concern as diagnosis and presentation represent a challenge, especially as …
Aarthi Sridhar, Anjana Gopi, Abhilasha Dalal, Divya Ravi
…of 2 microscopic methods for the diagnosis of Mycobacterium tuberculosis (M.tb) along with culture and drug susceptibility testing to first line drugs. : The cross-sectional study comprises 200 suspected cases of pulmonary tuberculosis both clinically and radiologically in KIMS, …
Stosic M, Vukovic D, Babic D, Antonijevic G, Foley KL, et al.
Background Multidrug resistant (MDR) tuberculosis (TB) represents TB which is simultaneous resistant to at least rifampicin (R) and isoniazid (H). Identifying inadequate therapy as the main cause of this form of the disease and explaining the factors leading to its occurrence, nu…
Konstantin Glebov, Anastasiia Russkikh, Anastasia Samoilova, O. V. Lovаchevа, I. А. Vаsilyevа, et al.
…s (DST) confirmation of drug resistance in newly identified tuberculosis (TB) patients is not possible, there is a serious problem when choosing the correct treatment regimen. Data on the drug resistance of the M. tuberculosis (MBT) source of infection can help in prescribing ade…
Olha Sakhelashvili-Bil
… children and 45 adolescents) from the multi-drug resistant tuberculosis sites underwent the complex clinical radiological and immunological examination. Insignificant functional disorders of cellular response (immunoregulatory processes) caused by the prevalence of suppressor an…
Maksi Puasa, Nur Chayati
…roduction: The increasing number of patients with resistant tuberculosis requires attention and efforts for prevention. Resistance causes more expensive cost of treatment, longer duration of treatment, more severe side effects and decreasing the chance of recovery. The specific p…