Showing 126–150 of 180 documents
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J Daniel, M R Marll, N Mofokeng, T Ngwanto, N Glover, et al.
…tudy in Johannesburg, South Africa, adults with and without HIV were enrolled within two weeks of treatment initiation for newly diagnosed, drug-susceptible pulmonary TB. Baseline demographic and clinical data were obtained at enrollment, and spirometry was performed according to…
Amit Barua, Joseph Hubble, Kathryn H. Yoo, Michael Lacassagne, John P. Areno, et al.
…urrences. We describe a 67yo, Human Immunodeficiency Virus (HIV) seronegative man, seen in the public health system in Louisiana, USA with multiple relapses of TB due to drug susceptible MTB despite successful completion of guideline based direct observed treatment regimen in eac…
Myers B, Carney T, Rooney J, Malatesta S, Ragan EJ, et al.
…zard and logistic regression models (adjusted for age, sex, HIV status and tobacco use) examined associations between smoked drug use and mycobacterial time to culture positivity (TTP), acid-fast bacilli sputum smear positivity and lung cavitation. RESULTS: People who smoked drug…
Melo KJC, Henostroza MAB, Löbenberg R, Bou-Chacra NA
…n causes of death worldwide and a leading cause of death in HIV patients. Rifampicin (Rif), a low water-soluble drug, is a critical first-line treatment and the most effective drug substance for therapy of drug-susceptible TB. However, Rif has high interindividual pharmacokinetic…
I. A. Lapyreva, O. S. Ilyina, A. S. Goncharov, E. A. Grigorieva, М. А. Плеханова
… therapy of patients with drug susceptible tuberculosis and HIV infection. Subjects and Methods. In 2020-2021, 40 patients with HIV infection and drug susceptible respiratory tuberculosis with a positive sputum test were examined in Moscow Regional Clinical TB Dispensary as a par…
Menonli Adjobimey, Anete Trajman, Mayara Lisboa Bastos, Chantal Valiquette, Diana Gibson, et al.
…TBD are preferred but can be skipped in persons living with HIV and children <5 years. There is equipoise on the need for these tests in other HHC. **METHODS:** We conducted a superiority, open label cluster-randomized trial in Benin and Brazil to compare three strategies to eva…
Gustavo Amorim, David W. Haas, Marcelo Cordeiro‐Santos, Afrânio Lineu Kritski, Marina C. Figueiredo, et al.
…sma samples from 448 patients; 110 (24.6%) were people with HIV, 9 (2.0%) had a grade 3 or higher ADR, and 15 (3.3%) had treatment failure/recurrence. Higher drug concentrations of INH, RIF and EMB were associated with increased odds of having ADR. High concentrations of INH sugg…
Muhammed S Bah, Kyaw Ko Ko Htet, Gregory P Bisson, Celso Khosa, Refiloe Masekela, et al.
…rbidity or risk factor with the four most recommended being HIV/AIDS (100%), pregnancy (73%) and liver disease (59%) and mental health (59%). Recommendations for linkage to care were more infrequent and also varied with the top four being HIV (88%), liver disease (47%), diabetes …
Sunday Olarewaju, Sunday C Adeyemo, Ayodele Ajayi, Obehi F Are-Daniel, Anu Chayelil Santhosh, et al.
…level of education (AOR = 0.175, P = 0.001) and living with HIV (AOR = 35.303, P = 0.017) were significantly associated with depression status. **CONCLUSION:** This study found a high prevalence of depression among TB patients. Factors such as level of education and comorbi…
Izudi J, Okello G, Bajunirwe F
… 0.51; 95% CI, 0.38-0.68), TB/human immunodeficiency virus (HIV) (aRR = 0.67; 95% CI, 0.51-0.88) or unknown HIV serostatus (aRR = 0.42; 95% CI, 0.26-0.68), and digital community-based directly observed therapy short-course (DOTS) (aRR = 0.42; 95% CI, 0.20-0.88). Conclusions The T…
Raphael NA, Garraud PA, Roelens M, Alfred JP, Richard M, et al.
…ation. Results Of the 16,545 patients, 14.7% had concurrent HIV coinfection, with a 66.2% success rate. The median treatment duration was 5 months, with patients averaging 30 years (with an interquartile range of 22-42 years). The estimated hazard of achieving a successful treatm…
Geliukh E, Nabirova D, Davtyan K, Yesypenko S, Zachariah R
… were from rural areas 229 (74%), unemployed 218 (71%), and HIV-infected 131 (43%). Individuals from urban areas (Adjusted risk ratio, ARR =0.9, 95% Confidence Interval, CI:0.89-0.94), having drug-resistant TB (ARR = 0.3, 95% CI: 0.18-0.45), and relapse TB (ARR = 0.6, 95% CI:0.40…
Josephine Amie Koroma, Mariama Mahmoud, Bailah Molleh, Stephen Sevalie, Adrienne K. Chan, et al.
…comes, after adjusting for age, gender, nutritional status, HIV status and treatment regimens. A p-value of <0.05 was considered statistically significant at 95% confidence level. Results Of the 701 drug-resistant TB patients, 383 (54.6%) were registered in the pre-COVID-19 pe…
Gates MRI
The purpose of this study is to determine if nicotinamide in combination with bedaquiline, pretomanid, and linezolid, is safe and effective in treating drug-susceptible pulmonary tuberculosis.
Pettit AC, Phillips PPJ, Kurbatova E, Vernon A, Nahid P, et al.
…ified subgroup of people with human immunodeficiency virus (HIV) (PWH). Methods PWH and CD4+ counts ≥100 cells/μL were eligible if they were receiving or about to initiate efavirenz-based antiretroviral therapy (ART). Primary endpoints of TB disease-free survival 12 months after …
Sathar F, Charalambous S, Velen K, Fielding K, Rachow A, et al.
…07, The Gambia: 367) (mean age 36 years, 66% male). Overall HIV prevalence was 42% but varied by country (South Africa: 68%, Tanzania: 49%, Mozambique: 45%, The Gambia: 7%). The overall median total delay was 6 weeks (IQR 4-10). People living with HIV (vs HIV negative; adjusted H…
Korri R, Bakuli A, Owolabi OA, Lalashowi J, Azize C, et al.
…years old, were included in the analysis. Around 54.7% were HIV positive. Most of the participants (416/486; 85.6%) in our cohort were considered cured at month 6. Only 40.4% of non-pregnant women of reproductive age used contraception at TB diagnosis. A total of 31 out of 486 wo…
Calderwood CJ, Wilson JP, Fielding KL, Harris RC, Karat AS, et al.
… of disaggregation of results, including by factors such as HIV status, baseline smear status, and the presence or absence of lung cavitation. Conclusions This systematic review found that most patients remained culture positive at 2 weeks of TB treatment, challenging the view th…
Michael Hoelscher, Prof, Andreas Diacon, Prof
This is a prospective, open label, two-centre, randomized, controlled, two-stage, phase Ib/IIa study to evaluate the safety, tolerability, PK, drug-drug interaction and bactericidal activity of BTZ-043 administered orally once daily over 14 days to participants with newly diagnos…
Deepak Saxena, Devang Raval, Somen Saha, Jignasa Sathwara, Nishad Halkarni, et al.
<sec> <title>BACKGROUND</title> Patients with Drug sensitive tuberculosis (DSTB) often face challenges in adhering to medications. Tuberculosis Monitoring Encouragement Adherence Drive (TMEAD) is a digital pillbox that provides reminders for pill consumption and facilitates the r…
Richard Delali Agbeko Djochie, Berko Panyin Anto, Mercy Naa Aduele Opare-Addo
…included initial body weight, weight gain during treatment, HIV status, drug adverse reactions, and mental well-being at the beginning of treatment. Multivariate analysis showed that gaining at least 3kg during treatment and having no risk of depression at the beginning significa…
Susan Shin-Jung Lee, M.D., Ph.D.
The development of efficacious, safe, and shorter treatment regimens could significantly improve TB management and treatment success rates. This prospective, 3-year, single arm study is to evaluate the efficacy and safety of a short-course, 4-month regimen including isoniazid(H),…
Somen Saha, Devang Raval, Deepak Saxena, Nishad Halkarni, Rahul Doshi, et al.
Abstract Background Drug-sensitive tuberculosis (DSTB) patients often face challenges in adhering to medications. Tuberculosis Monitoring Encouragement Adherence Drive (TMEAD)is an electronic cartridge-based dispensing module that dispenses patients’ daily dose in a small disposa…
Pettit AC, Shepherd BE, Sterling TR
Purpose of review The present review describes recent advances in the treatment of drug-susceptible tuberculosis (DS-TB) among people living with human immunodeficiency virus (PLWH). Recent findings Higher than standard rifampicin doses (>10 mg/kg/day) are well tolerated and have…
Jonathan Izudi, Simon Kyazze, Francis Bajunirwe
**RATIONALE:** Stigma has a profound effect on the well-being and treatment outcomes of people with tuberculosis (PWTB). Despite its negative effects, TB-related stigma remains underexplored in high-burden TB settings such as Uganda. **OBJECTIVE:** To examine the factors associa…