Showing 126–150 of 172 documents
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Reichler MR, Khan A, Sterling TR, Zhao H, Chen B, et al.
Background Close contacts of persons with pulmonary tuberculosis (TB) have high rates of TB disease. Methods We prospectively enrolled TB patients and their close contacts at 9 US/Canadian sites. TB patients and contacts were interviewed to identify index patient, contact, and ex…
Bennet R, Nejat S, Eriksson M
Aim We present our results using interferon-gamma release assays in any child Methods During 2000-2019, we investigated 892 children with a median age of seven years. We explored associations between TB infection and characteristics such as closeness to contact, age, sex, BCG sta…
Subash Babu, MBBS, PhD
The immune responses in latent tuberculosis are poorly understood. While it is difficult to define the onset of latency during natural infection, patients undergoing treatment for tuberculosis are driven into a state of latency or cure. The present study on the effect of 3 and 4 …
Herlev and Gentofte Hospital
This study will be investigating the effect of latent tuberculosis infection (LTBI) treatment on glucose tolerance and low-grade inflammation. Almost a century ago, researchers proposed that diabetes (DM) was associated with increased risk of Tuberculosis infection (TB). A more r…
Timothy Sterling, MD, Robert Belknap, MD, Amber Robinson, PhD, Rosanna M Boyd, PhD, Dick Menzies, MD
This study is conducted to compare the safety and effectiveness of a novel short 6-week regimen of daily rifapentine (6wP, experimental arm) with a comparator arm of 12-16 weeks of rifamycin-based treatment (standard of care, control arm) of latent M. tuberculosis infection (LTBI…
Dick Menzies, MD, MSc
Tuberculosis (TB) is spread by airborne transmission from adults with active contiguous TB to children, especially those living in the same household. Once children are exposed and infected they are at very high risk to develop active TB - which can be lethal if not detected and …
Walter K Kraft, MD
Drug therapy for persons living with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) co-infected with latent tuberculosis infection (LTBI) is complex. Anti-tuberculosis drugs used to treat LTBI often induce drug metabolizing enzymes that share the …
Julián de la Torre Cisneros, MD, José M. Aguado, MD, PhD
A multicenter, prospective, non-inferiority, randomized and open clinical trial comparing levofloxacin with isoniazid in the treatment of latent tuberculosis infection in patients eligible for liver transplantation. Patients over 18 years of age on the waiting list for liver tra…
Swartwood NA, Testa C, Cohen T, Marks SM, Hill AN, et al.
Background In the United States, the tuberculosis (TB) disease burden and associated factors vary substantially across states. While public health agencies must choose how to deploy resources to combat TB and latent tuberculosis infection (LTBI), state-level modeling analyses to …
Usman Iqbal, Rubeena Zakar, Gull Mahnoor Hashmi, Dur-e- Sabeeh, Minahil Abba, et al.
Objectives: To see the relationship of maternal vitamin D levels with birthweight of neonates in pregnant females with latent tuberculosis infection Methodology: A three arm randomized controlled trial was conducted in LTBI pregnant females. A calculated sample 99 parturient were…
Gavin Churchyard, MBBCh, PhD
This study is a parallel, two part, open label, individually randomized, pragmatic trial among HIV-positive individuals. Part A compares a single round of weekly high dose rifapentine plus isoniazid for three months (3HP) to six months of daily isoniazid (6H). Part B compares per…
Manresana de Micobacteriologia, SL
This is a doble-blind, masked, compared with placebo clinical trial in pediatric population in contact with tuberculosis with or without tuberculosis infection. This trial aims to study the effect of the probiotic Nyaditum resae® at the level of specific Treg memory cells eight w…
Mannebach K, Dressel A, Eason L
Tuberculosis (TB) is the deadliest infectious disease across the world, with the greatest burden occurring in India. Pregnant women and children are especially vulnerable to adverse effects from infection, and they tend to have diminished ability to protect themselves. Malnutriti…
Dick Menzies, MD
On a global scale, tuberculosis (TB) is the single most important infectious cause of morbidity and mortality. The World Health Organization has estimated that one-third of the entire world's population carries latent TB infection. A key TB control strategy is therapy of latent T…
Choi SH, Oh CE, Lee J, Cho YY, Kwon Y, et al.
Background Tuberculosis (TB) exposure in congregate settings related to neonates is a serious medical and social issue. TB exposure happens during the neonatal period, but contact investigations for exposed infants are usually conducted after the neonatal period. Generally, recom…
Woodruff R, Miramontes R
We examined tuberculosis (TB) infection results for the United States from the 2019-2020 National Health and Nutrition Examination Survey. Over this period, 10% of non-US-born persons and 7% of those >60 years of age tested positive for TB infection. These results provide up-to-d…
Lubyayi L, Mawa PA, Cose S, Elliott AM, Levin J, et al.
Background Immuno-epidemiologists are often faced with multivariate outcomes, measured repeatedly over time. Such data are characterised by complex inter- and intra-outcome relationships which must be accounted for during analysis. Scientific questions of interest might include d…
Arvidsson Å, Lafta G, Sönnerbrandt M, Sundelin K, Paues J
Background Pregnant women have an increased risk of developing active tuberculosis (TB). The Public Health Agency of Sweden recommends screening of active TB and latent tuberculosis infection (LTBI) among pregnant women from countries with high TB incidence at Maternal Health Car…
Kathamuthu GR, Moideen K, Kumar NP, Sridhar R, Baskaran D, et al.
Background Pulmonary tuberculosis (PTB) is characterized by elevated levels of acute phase proteins (APPs), but their association with tuberculous lymphadenitis (TBL) is poorly studied. Methods We examined the systemic levels of APPs (alpha-2-macroglobulin [⍺-2MG], serum amyloid …
Bullarbo M, Barnisin M, Vukas Radulovic N, Mellgren Å
Objective Studies on the prevalence of active tuberculosis (TB) and latent tuberculosis infection (LTBI) among high-risk pregnant and postpartum women are few and prevalence is not well known. The methods used for diagnosing and treating TB and LTBI also differ both within and be…
Yeun‐Jun Chung, Min Ji Ko, H.K. Song, Hyun Sun Ko
A 37-year-old primiparity woman in her 26th week of gestation was transferred to the obstetrical unit of a tertiary-care center for the evaluation of hydrops fetalis. Ultrasonographic findings were normal except for fetal ascites and pleural effusion. In spite of fetal treatment …
Siddhartha Chatterjee, Abira Datta, Basudev Bhattacharya, Rajib Gon Chowdhury, Siddhartha Chatterjee, et al.
Aim: To explore the possibility of risk factor between latent genital tuberculosis with association of low secretion anti-mullerian hormone(AMH) and low level of Vitamin D for infertility. Design: Retrospective study was done in the reproductive medicine unit of Calcutta Fertilit…
Mawa PA, Hasso-Agopsowicz M, Lubyayi L, Nabakooza G, Nakibuule M, et al.
Introduction: The immunogenicity of BCG vaccination in infants differs between populations. We hypothesized that prenatal exposure to mycobacterial antigens might explain the differences in immune responses to BCG seen in other studies of infants in Africa and the United Kingdom …
Naik S, Alexander M, Kumar P, Kulkarni V, Deshpande P, et al.
Background Recent studies in adults have characterized differences in systemic inflammation between adults with and without latent tuberculosis infection (LTBI+ vs . LTBI-). Potential differences in systemic inflammation by LTBI status has not been assess in pregnant women. Metho…
Badawi MM, SalahEldin MA, Idris AB, Idris EB, Mohamed SG
Every year, 10 million people fall ill with tuberculosis (TB). Despite being a preventable and curable disease, 1.5 million people die from TB each year -making it the world's top infectious disease. TB is the leading cause of death of people with HIV and also a major contributor…