MATERNAL VITAMIN D LEVELS AND ITS RELATIONSHIP WITH BIRTH WEIGHT OF NEWBORNS IN PARTURIENT WITH LATENT TUBERCULOSIS INFECTION

Objectives: To see the relationship of maternal vitamin D levels with birthweight of neonates in pregnant females with latent tuberculosis infection Methodology: A three arm randomized controlled trial was conducted in LTBI pregnant females. A calculated sample 99 parturient were selected and divided into three groups. As per dose of Vitamin-D supplementation participants were categorized in Group-A (No intervention/supplementation), Group-B (2000IU/day) and Group-C (4000IU/day). Vitamin D supplementation was given to the study groups as per study protocols. To maintain the safety measures throughout the study all the study participants were monitored for hypervitaminosis D. The primary outcome analysis was based on whether vitamin D supplementation has any impact on birth weight of neonates in LTBI pregnant females. Improvement in fetal vitamin D levels after supplementation was assessed as our secondary outcome. At the end of the study period, a total of 90 patients were available for follow up with an overall attrition of (n=9); four from Group-A, three from Group-B and two from Group-C. Results: Mean age of our study participants was 29±3.6 years. 44 (48.8%) participants were having BMI ≥ 25 kg/m2 while remaining were having BMI <25 kg/m2. There were only 14 (15.5%) participants that were having sufficient vitamin D levels, 23 (25.5%) participants were having insufficient Vitamin D levels and 53 (59%) were found deficient for vitamin D levels. An overall 85.8% (85/99) participants were having VD levels < 30ng/dl. Out of total 90 deliveries 21 (23.3%) participants delivered LBW babies. 15 females were from the group that was not receiving any supplementation, 04 females were from the group receiving 2000IU/day of VD and only 01 from the group receiving 4000IU/day supplements. The association was significantly reduced with supplementation of Vitamin-D as p-value <0.001. A positive correlation was found between maternal vitamin D and birthweight of newborn (ρ = 0.691 with p <0.001) Conclusions: A significant relationship exists between maternal vitamin D levels and birthweight of neonates. Taking Vitamin D by LTBI pregnant women is effective to decrease the incidence of low birth weight.