Assessment of Vitamin D Levels in Tuberculosis Patients: A Case–Control Study

Introduction: Vitamin D plays a crucial role in the immune response against Mycobacterium tuberculosis, yet its deficiency is commonly observed in tuberculosis (TB) patients. Methodology: This case-control study, conducted at Dr. PDMMC, Amravati, aimed to assess vitamin D levels in 40 TB patients compared to 40 healthy controls. Serum 25OHD3 levels were measured, and statistical analysis was performed using an independent t -test. Results: The mean 25OHD3 levels were 24.16 ng/mL in cases and 26.12 ng/mL in controls, with a P -value of 0.523, indicating no statistically significant difference. However, 60% of TB patients had vitamin D deficiency (<20 ng/mL) compared to 30% of controls, suggesting a possible association between TB and vitamin D deficiency. Additionally, lower socioeconomic status was more prevalent among TB patients (50%) than in controls (30%). Conclusion: While the difference in vitamin D levels was not statistically significant, the higher prevalence of deficiency among TB patients highlights the need for public health interventions focusing on dietary supplementation and awareness to improve TB outcomes.