Showing 126–150 of 200 documents
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He Y, Gong Z, Zhao X, Zhang D, Zhang Z
…d not comprehensively and accurately diagnose MTB, NTM, and drug resistance. Next-generation sequencing allows an "all-in-one" approach providing results on expected drug susceptibility testing (DST) and the genotype of NTM strains. In this study, targeted capture sequencing was …
Grigory Kaminskiy, Anna Panova, Karamov Ev, E. I. Veselova, Sergey Smerdin, et al.
…red to HIV<sup>-</sup> individuals: -S531L rpoB (rifampicin resistance), -M306V embB (etambutol resistance), -‘S531L rpoB + S315T(1) katG’ (isoniazid resistance), -‘S531L rpoB + S315T(1) katG + M306V embB’. The prevalence in HIV<sup>-</sup> individuals of S315T(1) katG not combin…
Wang, Chenyang
…eaths annually. Recent years have seen a concerning rise in drug-resistant tuberculosis cases, calling for the development of new approaches for drug susceptibility testing. The conventional gold standard, bacterial culture testing, can take up to six weeks to get results, potent…
Drug-resistant tuberculosis is a re-emerging public health concern which requires special attention all around the world.Among all the infectious diseases, drug-resistant tuberculosis is now the most lethal infection causing disease in both children and adults.The co-infection of…
Sandy Vitria Kurniawan, Jatu Aphridasari, A. Farih Raharjo
…nversion are the main indicators of successful treatment of drug-resistant tuberculosis patients. Evaluation of health-related quality of life (HRQoL) and the effect of treatment on HRQoL are often ignored. HRQoL assessment is an interesting outcome to evaluate and improve. Drug-…
Chuanqing Xu, Can Zhao, Songbai Guo, Xiaoyu Zhao
…-disease mortality rate. The invention of anti-tuberculosis drugs has aided in controlling tuberculosis, but drug resistance remains a significant challenge in its prevention and control. This study is based on tuberculosis reporting data released by the China CDC from 2004 to 20…
Pavel Tarlykov, Sabina Atavliyeva, Arike Alenova, Elena Zholdybayeva, Ye. Ramankulov
The incidence of drug-resistant tuberculosis in Kazakhstan has risen over the last decades, making it a serious threat. The purpose of this study was to characterize M. tuberculosis isolates circulating in the south of Kazakhstan, based on mutations of known association with mult…
Prakasini Satapathy, Ramaiah Itumalla, Ahmad Neyazi, Abdul Mobin Nabizai Taraki, Mahalaqua Nazli Khatib, et al.
Bedaquiline resistance is increasingly observed in the treatment of rifampicin-resistant tuberculosis (TB), yet standardized regimens for managing bedaquiline-resistant TB are lacking. Studies indicate a high proportion of bedaquiline-resistant cases have previously been treated …
Samah Mohammed Refay, Eman H. Ahmed, Ahmed Refaat Abd Elzaher, Ahmed Morsy, Manal M. Yasser, et al.
…and immunocompromised patients. The emergence of antibiotic resistance is a significant health problem and cancer patients are at risk of repeated infections with drug-resistant bacteria. OBJECTIVE: This investigation aimed to identify predictors of repeat infections of Escherich…
Dalenia Noa-Suárez, Liuvia Vázquez-Balart
Introduction: an increase in the number of drug-resistant tuberculosis patients has been observed in the last 10 years in Cuba and, especially, in Guantánamo province. This is the province with the highest incidence in the country. Objective: to identify the epidemiological chara…
Fredrick Ogumbo, Ronald Odero, Ben Odhiambo, Patrick Emojong, Albert Okumu, et al.
…uses of mortality and morbidity in developing countries and drug resistance remains a challenge. Drug resistance is hastened by point mutations in the bacilli genome and their frequencies vary geographically hence the need to understand regional specific patterns for early detect…
Astha Prasai, Abhishek Pant, Asmita Neupane, Subash Pant, Sailesh Pradhan
INTRODUCTION: Increasing antibiotic resistance has created a global public health threat worldwide. Acinetobacter species is one of the important pathogenic organisms in the hospital setting due to its ability to persist in the hospital environment for long. Its resistance to com…
Arslan Ahmed Salam, I. Majooka, Aamer Ikram
…tory increases chance of relapse with increases the risk of drug resistance among patients of relapse. Our study was aimed to find a co-relation between relapse and drug abuse along with associated symptoms. Methods and materials: A prospective cross-sectional study was conducted…
An H, Sun W, Liu X, Wang T, Qiao J, et al.
…rrently, Mycobacterium tuberculosis has exhibited increased drug resistance, leading to ineffective drug treatment in many patients with tuberculosis. Among the anti- Mycobacterium tuberculosis drugs, oxazolidinones have been gradually developed. Contezolid (MRX-I) has been newly…
Soundararajan DCR, Rajasekaran RB, Rajasekaran S, Shetty AP, Kanna RM
The alarming global increase in drug-resistant strains plagues the global fight to end tuberculosis (TB), especially in developing countries. The often reported poor treatment outcomes, sequelae, and lack of best practice guidelines in drug-resistant spinal TB poses a significant…
The steady growth of drug-resistant tuberculosis, charac-terized by low therapeutic efficacy, requires the develop-ment of innovative approaches to the treatment of this infection. One of such approaches is vaccine therapy that has immunostimulating activity and is capable to cor…
Gao X, Li T, Han W, Xiong Y, Xu S, et al.
Objective To investigate the positivity rates and drug resistance characteristics of Mycobacterium tuberculosis (MTB) among suspected tuberculosis (TB) patients in Shandong Province, the second-largest population province in China. Methods A prospective, multi-center study was co…
Song WM, Shao Y, Liu JY, Tao NN, Liu Y, et al.
…e of TB-DM cases (refers to TB patients with diabetes), and drug-resistant tuberculosis cases (DR-TB), it is of great significance to explore the association between diabetes and primary DR-TB for TB elimination target in China. We assessed the clinical characteristics, drug-resi…
Fana TE, Ijeoma E, Sotana L
…knowledge and awareness levels, attitudes, and practices of Drug Resistant Tuberculosis. A quantitative descriptive cross sectional study was carried out in the Eastern Cape Province of South Africa. The sample size consisted of four hundred (400) respondents aged 18 years and ab…
Amusengeri A, Khan A, Tastan Bishop Ö
…g cause of morbidity and mortality in developing countries. Resistance to the first-line anti-TB drugs, isoniazid (INH) and rifampicin (RIF), is a major drawback to effective TB treatment. Genetic mutations in the β-subunit of the DNA-directed RNA polymerase ( rpoB ) are reported…
Carolina H Chung, Rupa Bhowmick, Annie J Badenoch, Harkirat S Arora, Sriram Chandrasekaran
Drug resistance is a major challenge in cancer and infectious diseases, requiring innovative solutions. Recent research suggests that bacteria and cancer cells reprogram their metabolism and manipulate their external metabolic environment to resist a diverse range of therapeutics…
Sivakumar S, Chandramohan Y, Kathamuthu GR, Sekar G, Kandhasamy D, et al.
…ed from extra pulmonary lymph node samples and subjected to Drug susceptibility testing and spoligotyping was carried out. In addition, immunological characterization from blood of same individuals from whom M.tb was isolated was carried out between the two major lineages groups …
Navinchandra M. Kaore, Sushmita Mukherjee, Shilpa N. Kaore, Surender Kaur
…ing reported annually, 9 percent of which exhibit extensive drug resistant TB. With 9.6 cases per lac population early detection of drug resistance at peripheral levels is must. The study was planned to use Fluorescent microscopy (FM) with Fluorescein Diacetate Ethidium Bromide (…
Yani DI, Juniarti N, Lukman M
…ety of factors influenced the decision of tuberculosis (TB) drug-resistant patients to continue treatment. The study aimed to analyze factors that influence complying with anti-TB medications in patients with TB drug resistance in Indonesia. Patients and methods The study employe…
Michael B. Hall, Lachlan Coin
…utations associated with Mycobacterium tuberculosis complex drug resistance.1Walker TM Miotto P Köser CU et al.The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis.Lancet Microbe. 2022; 3: e265-e273Summary Fu…