Showing 126–150 of 200 documents
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Dongxia Zhu, Martin R. Bryce
…ficacy, high systemic toxicity, and ineffectiveness against drug-resistant M. tuberculosis. As a characteristic lesion of TB, granulomas have a compact construction, which greatly limits the access of small-molecule antibiotics to the necrotic area to kill M. tuberculosis [1]. Mo…
Lee GO, Comina G, Hernandez-Cordova G, Naik N, Gayoso O, et al.
…ristics were similar regardless of HIV co-infection and for drug-susceptible versus drug-resistant tuberculosis. Tuberculosis treatment response may be meaningfully assessed by objectively monitoring the time spent coughing. This measure demonstrated that cough was increased in p…
М.І. Lynnyk, V. І. Іgnatieva, Г. Л. Гуменюк, V.А. Svyatnenko, V.Ye. Ivashchenko, et al.
…ulmonary TB with preserved sensitivity to antimycobacterial drugs (DSTB) and with drug resistance.
 OBJECTIVE. To investigate the dynamics of the course of pathological changes in the lungs in patients with pulmonary TB against the background of coronavirus infection by anal…
Jeong D, Kim J, Lee SW, Choi H, Sohn H, et al.
…rt included 373,812 patients (375,440 episodes) with either drug-susceptible TB or drug- resistant TB. TB notifications declined by approximately 60% over the study period, while the median patient age continued to rise. Treatment success improved over time, accompanied by reduct…
Maserumule MC
…esent potentially more effective therapeutic strategies for drug-resistant TB. My study describes a novel critical role for Toll-like receptor (TLR) 8 in phagosomal sensing of mycobacterial RNA and subsequent enhancement of intracellular killing of MTB. I showed that TLR8 senses …
Muhammad Farman, Shahid Mehmood Malik, Ali Akgül, Nadeem Salamat
… the airborne infectious illness tuberculosis (TB). Several drug-susceptible (DS) and drug-resistant (DR) forms of the causative agent, Mycobacterium tuberculosis (MTB), are currently common in the majority of affluent and developing nations, particularly in Bangladesh, and compl…
Simran Sharma, Rohit Ajitsingh Macharekar, Tirumalai R. Raghunand
…organism of human tuberculosis (TB).Additionally, intrinsic resistance mechanisms that either degrade or modify antibiotics further reduce the effectiveness of anti-TB drugs. To overcome the problem of permeation, it is important that transport mechanisms across the mycobacterial…
Alfi Nurul Islamiyah, Syarifuddin Syarifuddin, Morsalina Akhsa, Iis Rukmawati, Eni Margayani, et al.
…r effective disease control and preventing the emergence of drug resistance. This study aimed to evaluate the rationality of TB treatment among newly diagnosed drug-susceptible pulmonary TB patients in a primary care center in Bandung. A descriptive-analytical study was conducted…
Coetzee JL, Kriel NL, Loubser J, Dippenaar A, Sampson SL, et al.
… tuberculosis (TB) treatment is typically effective against drug-susceptible Mycobacterium tuberculosis, but can fail due to acquired drug resistance or phenotypic resistance. M. tuberculosis persisters, a subpopulation of viable but non-replicating (VBNR) antibiotic-tolerant bac…
V. Guseva, I. А. Vаsilyevа, V. V. Testov
…ty of treatment for respiratory tuberculosis with confirmed drug susceptibility of M. tuberculosis using short-course regimens and a six-month regimen, based on the published data. Subjects and Methods. A systematic search for randomized and quasi-randomized controlled clinical t…
Raju R, Prasad BM, Alavadi U, Saini S, Sabharwal M, et al.
…complete diagnostic evaluation of tuberculosis based on its drug-resistance profile is critical for appropriate treatment decisions. The TB diagnostic landscape in India has been transformed with the scaling-up of WHO-recommended diagnostics, but challenges remain with specimen t…
Sahoo SK, Ommi O, Maddipatla S, Singh P, Ahmad MN, et al.
… efforts to find potential chemotherapeutics active against drug-resistant (DR) Mycobacterium tuberculosis (Mtb), causative agent of Tuberculosis (TB) and to curb the current burdensome treatment regimen, herein we describe the synthesis and biological evaluation of urea and thio…
Е. Г. Чурина, А. В. Ситникова, О. И. Уразова, V. V. Novitskiy, M. R. Patysheva, et al.
…m of the disease and sensitivity of the pathogen to anti-TB drugs. Materials and methods . 40 patients (36 men and 4 women) with pulmonary tuberculosis (TB) were examined: 18 patients (16 men and 2 women, average age (44.56 ± 8.10) years) with disseminated tuberculosis (DTB) and …
Suresh S, Begum RF, Singh SA, Vellapandian C
Drug repurposing is an ongoing and clever strategy that is being developed to eradicate tuberculosis amid challenges, of which one of the major challenges is the resistance developed towards antibiotics used in standard directly observed treatment, short-course regimen. Surpassin…
Bockman MR, Engelhart CA, Cramer JD, Howe MD, Mishra NK, et al.
…mplete biological characterization, mechanism of action and resistance, and pharmacokinetic properties of ( S)-(-)-acidomycin are described. Acidomycin possesses promising antitubercular activity against a series of contemporary drug susceptible and drug-resistant M. tuberculosis…
Mitton-Fry MJ, Cummings JE, Lu Y, Armenia JF, Byl JAW, et al.
Developing new classes of drugs that are active against infections caused by Mycobacterium tuberculosis is a priority for treating and managing this deadly disease. Here, we describe screening a small library of 20 DNA gyrase inhibitors and identifying new lead compounds. Three s…
Edgardo A. Ferrán, Eliza Alexander, James Brown, A Gibertoni-Cruz, MCI Lipman, et al.
…oduction</h3> Recent trial data have demonstrated that both Drug-sensitive (DS) and Drug-resistant (DR) tuberculosis (TB) can be treated effectively with short-course quinolone-containing combination therapy. Current WHO guidance includes using a four-month treatment with quinolo…
Rajendra Prasad, Abhijeet Singh, Nikhil Gupta
Drug-susceptible tuberculosis (DS-TB) requires treatment with first-line drugs (FLDs) whereas drug-resistant TB (DR-TB) are treated with combination of second-line drugs (SLDs) and fewer FLDs. Adverse drug reactions (ADRs) to these drugs are quite evident as they are being used f…
Lun S, Xiao S, Zhang W, Wang S, Gunosewoyo H, et al.
…via targeting of Pks13. These compounds were active on both drug-susceptible and drug-resistant strains of M. tuberculosis as well as showing low cytotoxicity to healthy cells and a promising selectivity profile. No cross-resistance was found between the coumestan derivatives and…
University of Virginia
…among undernourished populations, and that suboptimal serum drug concentrations are associated with delayed response to treatment, death, and acquired bacterial drug resistance. Serum drug exposures can be approximated by urine excretion as measured by spectrophotometry, replacin…
Campodónico VL, Rifat D, Chuang YM, Ioerger TR, Karakousis PC
…6D lead to changes in cell wall permeability and to altered resistance to environmental stresses and drugs. Methods: The phenotypes of a fully drug-susceptible clinical strain of Mtb and its paired rifampin-monoresistant, RpoB H526D mutant progeny strain were compared. Results: T…
Shanghai Pulmonary Hospital, Shanghai, China
…edaquiline, moxifloxacin, and pyrazinamide in patients with drug-susceptible tuberculosis. This is a prospective, randomized, controlled, multicenter study planned to enroll 45 rifampicin-susceptible tuberculosis patients, who will be randomized in a 1:1:1 ratio to the BZMD group…
Workie MG, Aycheh MW, Birhanu MY, Tsegaye TB
…lure of attending two scheduled appointments to collect the drugs in either phase of tuberculosis treatment. Even if TB treatment is crucial to achieve a cure and avoid the emergence of drug resistance, treatment interruption is the most testing and deterring factor for successfu…
Kumar A, Boradia VM, Thakare R, Singh AK, Gani Z, et al.
Background The emergence of drug-resistant bacteria is a major hurdle for effective treatment of infections caused by Mycobacterium tuberculosis and ESKAPE pathogens. In comparison with conventional drug discovery, drug repurposing offers an effective yet rapid approach to identi…
Dadwal R, Paul S, Gupta P, Yadav R, Sood S, et al.
…lining the significance of rapid and accurate prediction of drug resistance as an indispensable need of the hour. In the present study, we optimized and evaluated a stable isotope labeling-based approach using the MALDI-TOF MS (Matrix-Assisted Laser Desorption/Ionization-Time of …