Showing 126–150 of 200 documents
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Gunar Günther, Lorenzo Guglielmetti, Claude Leu, Christoph Lange, Frank van Leth, et al.
…sis control at times of emerging Mycobacterium tuberculosis drug resistance. Methods We investigated access to genotypic and phenotypic M tuberculosis drug susceptibility testing (DST), availability of anti-tuberculosis drugs and calculated cost of drugs and treatment regimens at…
Tuelo Mogashoa, Lucy Mupfumi, Thato Iketleng, Pinkie Melamu, Nametso Kelentse, et al.
Background The emergence and transmission of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (Mtb) strains is a serious threat to tuberculosis control in Botswana. Early detection of drug-resistant isolates is critical to ensure optimal t…
Mizukoshi F, Kobayashi N, Kirikae F, Ohta K, Tsuyuguchi K, et al.
Clinical isolates of drug-resistant (isoniazid and/or rifampicin-resistant) Mycobacterium tuberculosis were obtained from 254 patients diagnosed with drug-resistant tuberculosis in Japan from April 2015 to March 2017 in National Hospital Organization hospitals. The 254 patients w…
Nattakarn Preehativong
… health problem in Thailand according to the high burden of drug resistant tuberculosis. The drugs used in the treatment of drug resistant tuberculosis are classified as new drugs or drugs with new indications that need to use with precautions in closely monitoring This article w…
О.С. Шевченко, Svitlana Matveyeva, Anna Stepanenko, Olexandra Choporova, Olha Pohorielova
PECULIARITIES OF DRUG-RESISTANT TUBERCULOSIS IN UKRAINE AND KHARKIV REGION 
 Shevchenko O., Matveyeva S., Stepanenko A., Choporova O., Pohorielova O.
 Background. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis remain severe epidemic problem…
Trương Thiên Phú, Thuy Le, Viet Tran, Tung Thanh Phan
…ground: Tuberculosis (TB) still threatens human beings when drug-resistant tuberculosis (DR-TB), such as rifampicin-resistant TB, isoniazid-resistant TB, multidrug-resistant TB (MDR-TB), pre-extensively drug-resistant TB, and extensively drug-resistant TB increases continuously. …
LaFreniere M, Hussain H, Vachon J
Background Drug-resistant tuberculosis (TB) is a global public health issue. To monitor this in Canada, surveillance systems have been in place for the last 20 years. Objective To describe drug resistance patterns among TB isolates in Canada in 2017 by type of resistance as well …
O'Toole RF
…demic has had on the control of tuberculosis (TB) including drug-resistant forms of the disease. Antimicrobial resistance increases the likelihood of worsened outcomes in TB patients including treatment failure and death. Multidrug-resistant (MDR) strains, resistant to first-line…
Cuiyu Liu, Suping Li, Pan Baoshan, Hui Xing, Liang Bohui, et al.
Objective To understand the prevalence of drug resistance in pulmonary tuberculosis (TB) patients in Jiamusi, Heilongjiang province, and provide reliable references for the prevention and control of TB. Methods Mycobacterium tuberculosis strains isolated from 575 TB cases collect…
Nesri Padayatchi, MBChB, PhD
…omparing treatment success of a gene-derived individualized drug-resistant Tuberculosis regimen to a standard Tuberculosis regimen based on South African National Tuberculosis guidelines. When drug resistance is detected by molecular methods such as the Xpert MTB/RIF assay, seco…
Siddharth G. Chatterjee, Arvind Pandey
Background: India has largest population of drug resistant tuberculosis, the treatment of which is long and full of adverse drug reactions. Despite the ongoing research in clinical and pharmacological aspects, quality of life in drug-resistant tuberculosis remains less explored. …
Prabha Desikan, Aseem Rangnekar, Nikita Panwalkar, Ram Prakash Punde, Sridhar Anand
Detection and treatment of drug resistance in extrapulmonary tuberculosis (EPTB) is a major challenge worldwide. Drug resistance in EPTB has not been studied extensively. However, patients with drug-resistant EPTB have been reported to have poor outcomes[1]. Rifampicin and isonia…
Naila Samad, Ghulam Mustafa Wardak, Fakhra Batool, Hadeel Ahmed Kenoosh, Nnamdi C. Opara, et al.
Background. Pakistan is high burden drug resistant tuberculosis (DR-TB) country. For devising a treatment regimen and optimizing empirical drug therapy, the local epidemiology and drug resistance patterns are needed to be considered. Objectives. To evaluate the drug resistance pa…
Liu L, Zhao X, Wu X, Li S, Liu B, et al.
Background The emergence of antimicrobial resistance against Mycobacterium tuberculosis (M. tuberculosis) has become the major concern in global tuberculosis control due to its limited therapy options and high mortality. However, the clinical and molecular characteristics of drug…
Sarwer MI, Khan MT, Khurshid S
Introduction Phenotypic drug susceptibility testing is the most common approach to assess drug-resistant isolates; however, molecular methods of drug susceptibility testing are fast, accurate hence, offer less time for transmission during the diagnosis period. As data on the mole…
Olatunde Olayanju
Background: There is widespread concern about the rise of drug-resistant TB because treatment outcomes of affected patients remain poor and treatment options are limited. After more than a forty-year gap without any breakthrough discovery, several new (bedaquiline and delamanid) …
Zeng X, Kwok JS, Yang KY, Leung KS, Shi M, et al.
Background Drug resistance in Mycobacterium tuberculosis (MTB) is one of the major challenges in tuberculosis (TB) treatment. However, known mutations cannot explain all of the cases of resistance and little research has focused on the relationship between insertions / deletions …
Maeda T, Kawada M, Sakata N, Kotani H, Furusawa C
Drug-resistant tuberculosis (TB) is a growing public health problem. There is an urgent need for information regarding cross-resistance and collateral sensitivity relationships among drugs and the genetic determinants of anti-TB drug resistance for developing strategies to suppre…
Sheikh BA, Bhat BA, Mehraj U, Mir W, Hamadani S, et al.
…easing burden of tuberculosis is mainly caused due to multi drug-resistance. The failure of conventional treatment has been observed in large number of cases. Drugs that are used to treat extensively drug-resistant tuberculosis are expensive, have limited efficacy, and have more …
Monika, Rakesh Yadav
…berculosis and the risk has worsened with the appearance of drug resistance, in particular multi drug resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). Antimicrobial resistance (AMR), is one of the most dominant health hazard that has emerged in the 21st century. …
Dipali Maganbhai Gavali, Binita Aring, Hiral Gadhavi, Akhlakahemad Nathamehta, Abhishek B Dave, et al.
…R-TB who had never been previously treated with second-line drugs. A prospective study was conducted in Culture and Drug susceptibility testing laboratory, Jamnagar and its associated Drug-Resistant Tuberculosis (DR-TB) centre. Materials and Methods: Baseline second-line liquid c…
Dhruv Gandhi, Shatakshi Garg, Sonal Patil, Dhruv Mamtora, Ira Shah
…olved from conventional methods like culture and phenotypic drug-sensitivity testing (pDST) to rapid molecular assays such as line probe assays (LPA), Xpert MTB/Rif, Xpert Ultra, and Xpert MTB/XDR. While LPAs are highly sensitive and specific, they require specialized infrastruct…
Nimmo C, Millard J, Faulkner V, Monteserin J, Pugh H, et al.
Mycobacterium tuberculosis has acquired drug resistance to all drugs that have been used against it, including those only recently introduced into clinical practice. Compared to other bacteria, it has a well conserved genome due to its role as an obligate human pathogen that has …
Nduagu Samuel Uchechukwu, ONYEAGWARA Ngozi Carol, Ogisi Festus Oritsemajemite, MBATA Godwin Chukwuemeka
…challenge facing the global efforts against tuberculosis is drug-resistance, which necessitates the use of aminoglycoside-based second line drugs that are known to have ototoxic potentials. Hearing impairment can be a source of social distress, professional disability and in some…
Trigos AS, Goudey BW, Bedő J, Conway TC, Faux NG, et al.
The evolution of resistance to one antimicrobial can result in enhanced sensitivity to another, known as "collateral sensitivity." This underexplored phenomenon opens new therapeutic possibilities for patients infected with pathogens unresponsive to classical treatments. Intrinsi…