Showing 101–125 of 200 documents
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Bernatowska E, Skomska-Pawliszak M, Wolska-Kuśnierz B, Pac M, Heropolitanska-Pliszka E, et al.
Objectives The aim of the study was to estimate the rate of adverse reactions to live BCG Moreau vaccine, manufactured by Biomed in Poland, in severe combined immunodeficiency (SCID) patients. Material The profiles of 52 SCID patients vaccinated at birth with BCG, hospitalized in…
Greenblatt CL, Lathe R
…k, we provided a historical and molecular background to how vaccines, adjuvants, and their component molecules can elicit broad-spectrum protective effects against diverse agents, culminating in the development of the tuberculosis vaccine strain Bacille Calmette-Guérin (BCG) as a…
White AD, Sibley L, Gullick J, Sarfas C, Clark S, et al.
…h simian immunodeficiency virus (SIV) for the assessment of vaccines designed to prevent reactivation of TB. Following infection caused by aerosol exposure to an ultralow dose of Mycobacterium tuberculosis (M. tb), data trends indicated that subsequent coinfection with SIVmac32H …
Ishwarlall TZ, Okpeku M, Adeniyi AA, Adeleke MA
… unable to induce long-lasting protection. Various types of vaccines have been developed based specifically against M. ulcerans; however, to date, none has entered clinical trials or has been released for public use. Additional awareness and funding are needed for research in thi…
Adepoju VA, Onyezue OI
…ases and 1.4 million deaths in 2020 alone, new and improved vaccines are urgently needed. Recent advancements in TB vaccine research offer hope, but a lack of funding, coordination and understanding of immune responses have impeded progress. A TB Vaccine Accelerator Council aims …
Anurag Bhargava
Nutrition is essential to survival, health, and protection from disease across the lifespan. In the 1970s, an adequate diet was described as the most effective vaccine available for respiratory, diarrheal, and other common infections, as nutritional supplementation reduced these …
Dockrell HM, Butkeviciute E
The BCG vaccine will, in 2021, have been in use for 100 years. Much remains to be understood, including the reasons for its variable efficacy against pulmonary tuberculosis in adults. This review will discuss what has been learnt about the BCG vaccine in the last two decades, and…
Schaltz-Buchholzer F, Kjær Sørensen M, Benn CS, Aaby P
Background Following the introduction of oral Bacille Calmette-Guérin (BCG) a century ago, Albert Calmette suggested that BCG both provided protection against death from tuberculosis (TB) and other causes. The findings were not pursued. Today, there is considerable evidence that …
Wong NX, Buttery J, McMinn A, Azhar Z, Crawford NW
Bacille Calmete-Guerin vaccine is widely administered to reduce the risk of severe tuberculosis disease in children. Recent global vaccine supply issues have led to the use of alternative products, which may vary in side effect profile. We report on the safety of the Polish (More…
Stewart EL, Counoupas C, Quan DH, Wang T, Petrovsky N, et al.
…able protection; however, the development of more effective vaccines is hindered by a lack of defined correlates of protection (CoP) against M. tuberculosis . Pulmonary vaccine delivery is a promising strategy since it may promote lung-resident immune memory that can respond rapi…
Liebler-Tenorio EM, Heyl J, Wedlich N, Figl J, Köhler H, et al.
…models to compare reactions to different mycobacteria or TB vaccines.
Justiz Vaillant AA, Grella MJ
…unities alike. The gamut of diseases currently addressed by vaccines is extensive, encompassing diphtheria, tetanus, pertussis, poliomyelitis, measles, mumps, rubella, pneumococcal pneumonia, smallpox, sepsis, meningitis, hepatitis B, varicella-zoster, tuberculosis, cholera, rota…
BioNTech Responsible Person
…ill evaluate four dose levels of the BNT164 investigational vaccines (BNT164a1 and BNT164b1) to select a safe and tolerable dose in a three-dose schedule. Enrollment for BNT164a1 and BNT164b1 will be conducted independently, and in parallel. The trial will enroll participants di…
Michele Tameris, M.B.Ch.B.
The purpose of this study is to determine the safety, tolerability, and immunogenicity in BCG-vaccinated healthy adult subjects of an investigational vaccine being developed for the prevention of pulmonary tuberculosis.
Roces CB, Hussain MT, Schmidt ST, Christensen D, Perrie Y
…(lungs) have been considered for the development of subunit vaccines. Inert delivery systems such as poly (lactic-co-glycolic acid) (PLGA) are an interesting approach due to its approval for human use. However, PLGA suffers hydrolytic degradation when stored in a liquid environme…
Kwon BE, Ahn JH, Park EK, Jeong H, Lee HJ, et al.
Early secretory antigenic target-6 (ESAT6) is a potent immunogenic antigen expressed in Mycobacterium tuberculosis as well as in some non-tuberculous mycobacteria (NTM), such as M. kansasii . M. kansasii is one of the most clinically relevant species of NTM that causes mycobacter…
Yang Wang, Fei Ge, Junhai Wang, Hanglin Li, Boyang Zheng, et al.
…bstacle to the development of safe and effective killed RSV vaccines.
ФГБОУ ВО «Астраханский государственный медицинский университет» Минздрава России, Л. Г. Тарасова, E.N. Streltzova
BCG is a unique vaccine. It was created and successfully used for specific prevention of tuberculosis. Reactivation of the BCG scar is a transient condition that occurs against the background of various diseases, capable of resolving itself, does not involve surgical intervention…
Gönül Aslan, Deniz Alkaya
ÖzTüberküloz (TB) Mycobacterium tuberculosis kompleksi'nin etken olduğu ciddi etkileri nedeniyle insanlık tarihi boyunca toplumları derinden etkileyen bulaşıcı bir hastalıktır.TB'den korunmada tarihi bir öneme sahip olan Bacille Calmette-Guérin (BCG) aşısı 100 yıllık geçmişi ile
World Health Organization
Darmanger, A. M., Nekzad, S. M., Kuis, M., ten Dam, H. G.
A. М. Krychkovska, N. L. Zayarnyuk, О. І. Lopatynska, L. D. Bolibruh, В. П. Новіков
International scientific and practical conference «New trends and unresolved issues of preventive and clinical medicine» : Conference proceedings, September 25–26, 2020. Lublin : Izdevnieciba «Baltija Publishing», 2020. 428 pages.
World Health Organization = Organisation mondiale de la Santé
Goudouris E, Aranda CS, Solé D
Objectives Since the beginning of its use for the prevention of tuberculosis (TB) in 1921, other uses of BCG (Bacillus Calmette-Guérin) have been proposed, particularly in the treatment of malignant solid tumors, multiple sclerosis, and other autoimmune diseases. Its beneficial i…
Wang J, Xie T, Ullah I, Mi Y, Li X, et al.
Concerns were brought to the attention of the journal's editorial office after the paper was published [...].