Mycobacterium bovis BCG Given at Birth Followed by Inactivated Respiratory Syncytial Virus Vaccine Prevents Vaccine-Enhanced Disease by Promoting Trained Macrophages and Resident Memory T Cells
Yang Wang, Fei Ge, Junhai Wang, Hanglin Li, Boyang Zheng, Wenjian Li, Shunyan Chen, Xiaoqing Zheng, et al. (11 authors)
Journal of Virology · 2023-02
Abstract
RSV is the leading cause of severe lower respiratory tract infection of infants. ERD, characterized by Th2-biased responses, inflammation, and poor immune memory, has been an obstacle to the development of safe and effective killed RSV vaccines.
MeSH terms
- Biology
- Virology
- Mycobacterium bovis
- Immune system
- Virus
- Respiratory system
- Immunology
- Vaccination
- Disease
- Respiratory tract
- BCG vaccine
- Immunological memory
- Immunity
- Mycobacterium tuberculosis
- Microbiology
- Tuberculosis