Showing 101–125 of 200 documents
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John Metcalfe, Peter Bacchetti, Aliasgar Esmail, Andrew Reckers, David Aguilar, et al.
…for all drugs except isoniazid) using an external cohort of HIV-positive patients treated for latent TB infection with daily isoniazid (HIV/LTBI cohort) in Uganda. Results Among the 57 DR-TB patients (58% with pre-XDR/XDR-TB; 70% HIV-positive) contributing analyzable hair samples…
Ashley D, Hernandez J, Cao R, To K, Yegiazaryan A, et al.
…th Type 2 Diabetes (T2DM) and human immunodeficiency virus (HIV) infection. Multidrug-resistant M. tb infection (MDR-TB) is challenging to treat with existing therapeutics, so novel therapeutics and treatment strategies must be developed. Host-Directed Therapy (HDT) has been a po…
Maïssala Zoutené, Akouvi Mawussé Edjodjinam Ako, Koffi Atsu Aziagbe, Narcisse Viani Gateu Tadjom, Tété Amento Stéphane Adambounou, et al.
…62-year-old woman living with human immunodeficiency virus (HIV), previously treated for MDR-TB, developed XDR-TB during the course of treatment. The patient died on the 29th day of XDR-TB treatment. **CONCLUSIONS:** XDR-TB is a curable disease. Early and accurate diagnosis allo…
World Health Organization. Regional Office for South-East Asia
…treatment success; establishing interventions to address TB/HIV and MDR-TB; forging partnerships to ensure equitable access to an essential standard of care to all TB patients, and contributing to strengthening health systems. Member countries have also developed national plans i…
Yin Mon Thant
…tion for those with diabetes, human immunodeficiency virus (HIV), smoking and undernutrition. Myanmar, with 54 million people, has an incidence of all forms of TB of 322 per 100 000 population, with mortality of 36 per 100 000 population. Myanmar is one of the 30 high TB burden c…
Arslan Ahmed Salam, Aamer Ikram, Maha Fatima, Najma Javed Awan
…ethodology: A cross-sectional study was conducted among 200 HIV-negative relapsed TB patients from 2016-2017 in Mayo Hospital Lahore. The patients’ sputum samples were tested by Ziehl-Neelsen staining to observe acid-fast bacilli. The demographics and medical history of patients …
Cynthia Bin Eng Chee, David S.C. Hui
… and isoniazid, the latter in human immunodeficiency virus (HIV)-infected persons) as alternatives to 6–9 months of isoniazid has emerged.16-18 The only licensed TB vaccine, BCG (bacille Calmette–Guerin), has been in use since 1920 and does not confer substantial protection again…
Bonjorno AF, Pavan AR, Fernandes GFS, Scarim CB, Castagnolo D, et al.
…e diagnosed with TB, resulting in the deaths of 1.4 million HIV-negative individuals. The emergence of multidrug-resistant TB (MDR-TB), defined as resistance to at least rifampicin (RIF) and isoniazid (INH), and extensively drug-resistant TB (XDR-TB), poses the primary challenge …
Borah P, Deb PK, Venugopala KN, Al-Shar'i NA, Singh V, et al.
…ns, and drug-drug interactions among anti-TB drugs and anti-HIV therapies. Thus, there is a compelling demand for newer anti-TB drugs or regimens to overcome these obstacles. Considerable multifaceted transformations in the current TB methodologies and molecular interventions und…
Tetart M, Meybeck A, Assaf A, Valette M, Choisy P, et al.
…d in 32 patients (17%), extrapulmonary TB in 107 (56%), and HIV infection in 44 (23%). The proportion of loss to follow-up was 15%. In multivariate analysis, the risk of loss to follow-up decreased in case of first TB treatment (OR 0.36; 95% CI: 0.14-0.92, P=0.03) and increased i…
И. Б. Викторова, В. Н. Зимина, Sergey Dolgikh, Svetlana Degtyareva, Arkadiy Khanin
…amine the characteristics of recurrent tuberculosis (TB) in HIV patients. <b>Materials and Methods:</b> retrospective study of all recurrent HIV/TB cases following cure or successful treatment completion (n=153) registered in 2013 -2017 in Novokuznetsk, Russia (regional TB incide…
Miiro E, Olum R, Baluku JB
…6.5%), and disseminated TB (3.8%) are also encountered. The HIV co-infection rate is reported to be 5.0% to 81.3% while 2.6% to 25.4 % have diabetes mellitus. Clinical symptoms of DR-epTB are consistent with morbidity in the affected body system. Among patients with DR-epTB, the …
Shiromwar SS, Khan AH, Chidrawar V
…er, use of antiretroviral treatment in XDR-TB patients with HIV infection have not shown any significant difference in the treatment outcome. Conclusions XDR-TB treatment success can be achieved by implying standardized definitions, upgraded diagnostic procedures, and novel drugs…
N. V. Stavitskaya, Irina Felker, Е. М. Жукова, А. I. Tlif, N. P. Doktorovа, et al.
…g resistant tuberculosis (MDR/XDR TB), including those with HIV infection, whose chemotherapy regimens included bedaquiline. Subjects and methods: 70 patients with MDR/XDR TB were enrolled in the retrospective two-center study, the multivariate analysis of treatment outcomes with…
Chaidir L, Ruesen C, Dutilh BE, Ganiem AR, Andryani A, et al.
… applied for strains from 322 human immunodeficiency virus (HIV)-negative adult TB patients. Phenotypic drug susceptibility testing (DST) was performed for a proportion of the patients. Results Using WGS, mutations associated with drug resistance to any TB drug were identified in…
Youssra Metarfi, Wissal Chellal, Zineb Ben Khadda, Hasnae Hoummani, Bouchra Amara, et al.
…n, and patients with MDR- and XDR-TB, as well as those with HIV co-infection. The studies examine a range of anti-TB drugs, from first-line treatments like isoniazid and rifampicin to second-line options such as bedaquiline and linezolid. Various sampling methods were employed, i…
Abdelgawad, Noha
…M burdens are particularly high due to factors such as high HIV prevalence. The treatment of TB and TBM presents significant challenges. Firstly, it typically involves numerous antibiotics taken over several months that may cause serious adverse effects, leading to poor adherence…
Kabelo Gabriel Kaapu, Ivy Rukasha
…variate analysis, male sex (aOR = 1.12; 95% CI: 1.00-1.27), HIV positivity (aOR = 1.28; 95% CI: 1.11-1.47), age ≥ 35 years (aOR = 2.01; 95% CI: 1.08-3.76), and XDR-TB (aOR = 3.05; 95% CI: 1.65-5.65) were independently associated with unfavorable outcome. **C…
Benedetta S, Vallini F, Guida M, Tammaro C, Biava M, et al.
…vely drug-resistant (XDR) TB strains, and co-infection with HIV. Areas covered The present review examines significant patent literature on TB chemotherapeutics from September 2021 to the present using the following databases, reaxys, google patent and espacenet. Only patents rep…
Wei X, Yue L, Zhao B, Jiang N, Lei H, et al.
…vely drug-resistant (XDR) strains, the double prevalence of HIV-TB co-infection, and the insufficiency of plentiful health care have led to an increased incidence of TB. It is noted that current drugs for treating TB have proved unsustainable in the face of highly resistant strai…
World Health Organization. Regional Office for South-East Asia
…anaging multi- and extensively drug-resistant tuberculosis, HIV-associated TB. The specific objectives of this meeting were to review progress and constraints in implementing the Stop TB strategy in Member States of the SEA Region; and provide guidance on adopting and applying th…
World Health Organization. Regional Office for South-East Asia
…ti- and extensively drug-resistant tuberculosis, as well as HIV-associated TB. The specific objectives of this meeting were to review progress and constraints in implementing the Stop TB strategy in Member States of the SEA Region; and provide guidance on adopting and applying th…
Ahmed S, Nandi S, Saxena AK
… were reported in 2019, which included deaths attributed to HIV-TB co-infection. It is curable by the prescribed Directly Observed Treatment Short (DOTS) course, but the situation becomes critical and alarming due to multi-drug resistant (MDR) and extensively drug-resistant (XDR)…
Zolelwa Sifumba
…Institute and six months of clinical trials in the Clinical HIV Research Unit at the University of Witwatersrand, Johannesburg. I am pleased to say that this work has recently been published by BMC Global and Public Health (Sifumba et al., 2024).The courage came from seeing Dr Da…
Abenezer Abraham Anito, Gemechis Abdissa, Yohannis Gezahegn, Ebrahim Umer Muhammed, Hunde Lemi
…low-up was strongly associated with unsuccessful outcome. • HIV is associated with poor outcomes with consistent effect in sensitivity analysis. Drug-resistant tuberculosis (DR-TB) remains a major public health challenge globally. Despite diagnostic advances and expanded access t…