Showing 101–125 of 200 documents
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Christian Auer, Aastha Gupta, C. Malbacius, A. Ghafoor, Yulene Kock, et al.
BACKGROUND: In 2022, the WHO recommended the 6-month regimens BPaL (bedaquiline + pretomanid + linezolid) and BPaLM (BPaL + moxifloxacin) as treatment options for most forms of drug-resistant TB. SLASH-TB estimates the cost-saving and cost-effectiveness for the healthcare system …
Masataka Matsumoto, Kaori Masuda, Kazumi Kaneshiro, Kiyonobu Takatsuki
<b>Background:</b> Poor adherence to treatment for <i>Mycobacterium avium</i> complex pulmonary disease (MAC-PD) is related to side effects (Adjemian J. et al. Ann Am Thorac Soc 2014; 11:9-16). An alternative to daily regimen is the less frequent administration but it requires th…
Chalamcharla M. Manjula, J. P. Majra
Background: Daily regimen anti-tuberculosis treatment was adopted by Revised National Tuberculosis Control Programme (RNTCP) as a step to achieve tuberculosis elimination by 2025 in India. The change was implemented prior to completion of pilot study, which necessitated this stud…
Tutik Kusmiati, Ni Made Mertaniasih, Johanes Nugroho Eko Putranto, Budi Suprapti, Nadya Luthfah, et al.
… of rifampicin-resistant (RR-TB) patients receiving shorter regimens. Correlation for all variables was analyzed. RESULTS: CRP, IL-1β, and QTc baseline showed significant differences between 45 RR-TB patients on intensive phase and continuation phase with p-value of <0.001, 0.040…
Tawanda Gumbo, Moti Chapagain, Gesham Magombedze, Shashikant Srivastava, Devyani Deshpande, et al.
…t can be 18–20 months with multidrug resistance. Ultrashort regimens that cure regardless of resistance status [“pan-tuberculosis regimens”] would be a major step towards global tuberculosis control. Starting with seven drugs [bedaquiline, delamanid, pretomanid, OPC-167832, sutez…
Yanping Li, Linlin Song, Zhen Feng, Feng Sun, Wei Zhang
Abstract Introduction: Potential hepatotoxicity, particularly significant hyperbilirubinemia, is a major challenge to promoting the rifapentine-based 4-month regimen (2HPMZ/2PMZ) for drug-sensitive tuberculosis. A more detailed description of hepatotoxicity profiles during the ap…
Е. П. Мышкова, Т. И. Петренко, Т. А. Колпакова
… the efficacy and safety of various anti-tuberculosis therapy regimens for multiple drug resistant (MDR) and extensive drug resistant pulmonary tuberculosis in the intensive phase of treatment lasting for 8 months minimum. Subjects and Methods . A single-center cohort prospective-r…
Min Zhu, Yuanyuan Chen
…s in each group. The control group was treated with 2-month regimens of isoniazide, rifampin, ethambutol and pyrazinamide, followed by 4-month regimens of isoniazide, rifampin and ethambutol. The observation group was treated with 4-month regimens of moxifloxacin, rifampin, etham…
Lovely Jain, Meenakshi Malik, Kulbir Kaur, Sarita Dogra, Abhishek Purohit, et al.
…rtaken to investigate the efficacy and safety of short-term regimens (STRs) for the treatment of DR-TB in children. Methods: We conducted a comprehensive literature search across PubMed, EMBASE, Scopus, CINHAL, Web of Science, Cochrane Library, major trial registries, and grey li…
Akshada Manik Shinde, Mandar Manik Shinde
…s demonstrated that intermittent or thrice-weekly treatment regimens are associated with higher risks of unfavorable outcomes compared to daily regimens, particularly in patients with drug-sensitive TB.In response to this evidence and in alignment with the World Health Organizati…
Andi Safutra Suraya, Fitriatul Jannah, Firnanda Erindia, Nurwahidah Nurwahidah, Ahla Chayatush Sholichah
…efulness of mobile health apps on adherence to TB treatment regimens and in healthcare workers.
 Method: This systematic review applied the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guideline. The results was reported in descriptive narrativ…
Imran Nazir, Mohammed A Almatrafi, Iffat Imran, Sayed Rahman, H.M.M. Abdullahi, et al.
…his study aims to compare the efficacy of the two treatment regimens (oral doxycycline/rifampicin or ciprofloxacin versus IV gentamicin plus oral doxycycline/rifampicin or ciprofloxacin) in Brucella bacteremia. Methods In this single-center, retrospective cohort study, we analyze…
Manoj Kumar Pippal Santosh
…tion). A total of 109 countries were using all -oral longer regimens for the treatment of MDR/RR -TB. Material and Methods: The present study is a hospital -based observational prospective non -randomized without a control group, which was performed at a nodal DRTB center, Depart…
Mega TA, Usamo FB, Negera GZ
Background Abacavir (ABC) and Zidovudine (AZT) based regimens are the preferred first line nucleoside reverse transcriptase (NRTIs) backbones being widely utilized for managing HIV infection in children. However, there is a dearth of data regarding the clinical outcomes and assoc…
Padmasawitri TIA, Saragih SM, Frederix GW, Klungel O, Hövels AM
…ew of economic evaluations on implementing new short-course regimens (SCR) for drug-sensitive and drug-resistant tuberculosis (TB), to explore how uncertainties due to the limited evidence in the studies were dealt with and to identify useful information for decision making from …
Hoogar V, Anil Kumar M, Hugara S
Background Tuberculosis case management has undergone various changes in recent years. Most of the decisions have been taken based on provider intelligence or perspective. It is essential to know the beneficiary perspective about the changes in RNTCP. DOTS providers are active wi…
Oki Nugraha Putra, Yulistiani Yulistiani, Soedarsono Soedarsono, Susi Subay
…efficacy of sputum conversion within 6 months of individual regimens containing bedaquiline in patients with drug resistant tuberculosis. Methods: We conducted a retrospective study among patients with drug resistant tuberculosis who were receiving individual regimens containing …
Hinders DC, Taal AT, Lisam S, da Rocha AM, Banstola NL, et al.
… measures for leprosy elimination. However, more potent PEP regimens are needed to increase the effect in groups highest at risk (i.e., household members and blood relatives, especially of multibacillary patients). The PEP++ trial will assess the effectiveness of an enhanced prev…
Jason E Cummings, Lisa K Woolhiser, Vincent Guglielmi, Machenzie Wernsman, Ashley Romano, et al.
…cin. **RESULTS:** By day 12, the HD-RIF+HZM and HD-RPT+HZM regimens reduced lung bacterial burdens from 6.59 ± 0.08 logCFU in untreated controls to 3.70 ± 0.19 and 3.91 ± 0.43 logCFU, respectively. By day 54, bacterial loads were undetectable (<1 logCFU) in all gr…
Decroo T, Maug AKJ, Hossain MA, Uwizeye C, Gumusboga M, et al.
…le-free rifampicin-resistant tuberculosis (RR-TB) treatment regimens are recommended. However, acquired resistance preventing activity was overlooked. No previous study assessed the effect of shortening the duration of kanamycin administration to 2 months during the intensive pha…
Christian Michael, Maral Budak, Pauline Maiello, Kara Kracinovsky, Mark A. Rodgers, et al.
…e quarantined, complicating and prolonging multi-antibiotic regimens. Determining which antibiotic regimens are optimal for reducing treatment time and toxicity is a goal of recent TB eradication campaigns. Clinical trials are expensive and challenging, making it difficult to unt…
Antonio Rivero, MD PhD, Luis Lopez-Crtés, MD, PhD, Rafael Castillo, MD, José Verdejo, MD, Miguel Angel García, MD, et al.
To evaluate adherence and safety of three regimens of chemoprophylaxis for tuberculosis (TB) in HIV-infected patients with positive tuberculin skin test. DESINGS: We performed a randomised, comparative and open clinical assay carried out in 316 HIV-infected patients. The patient…
Huashan Hospital
This is an investigational, prospective, multicenter, single-arm, open label trial. The goal of this clinical trial is to evaluate the efficacy and safety of a 6-month all-oral regimen, consisting of Bedaquiline (BDQ, B), Delamanid (DLM, D), Linezolid (LZD, L), Levofloxacin (LFX)…
Qiao-Ling Ruan, Qing-Luan Yang, Chun-Lian Ma, Miao-Yao Lin, Xi-Tian Huang, et al.
…l for the end TB Strategy, but shorter and better tolerated regimens are needed to boost its coverage and acceptance. **METHODS:** Silicosis patients aged 18 to 65 years received a novel 1H3P3 regimen (400 mg isoniazid and 450 mg rifapentine, thrice-weekly for 4 weeks) un…
Pieterman ED, Keutzer L, van der Meijden A, van den Berg S, Wang H, et al.
… alarmingly low. Therefore, more effective and less complex regimens are urgently required. Methods We compared the efficacy of an all oral DR tuberculosis drug regimen consisting of bedaquiline (25 mg/kg), delamanid (2.5 mg/kg), and linezolid (100 mg/kg) (BDL) on the mycobacteri…